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Carboplatin

卡铂,卡波铂,JM-8,CBDCA,NSC-241240,JM 8,NSC 241240,JM8,NSC241240

Carboplatin (卡铂) 能与DNA结合，干扰细胞修复。

目录号
EY0923
EY0923
EY0923
EY0923
纯度
99.28%
99.28%
99.28%
99.28%
规格
25 mg
50 mg
100 mg
200 mg
原价
300
400
500
800
售价
300
400
500
800
库存
现货
现货
现货
现货
订购
订购
订购
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  • 生物活性

    Carboplatin is a second generation potent platinum-based antineoplastic agent that is believed to form inter- and intrastrand DNA adducts which activate signaling pathways culminating in apoptosis. Carboplatin is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism. Antitumor agent that forms platinum-DNA adducts. Causes intra- and interstrand DNA crosslinks blocking DNA replication and transcription. The development of carboplatin was inspired from the efficacy of its progenitor, Carboplatin displays potent antitumor activity and lower nephrotoxicity than Cisplatin. The action of this group of platinum-based compounds is primarily attributed to DNA adduct formation, however, these molecules also bind other biological molecules, including enzymes, which might play a role in their mechanism of action.

  • 体外研究

  • 体内研究

    30% PEG 400+0.5% Tween 80+5% Propylene glycol+ddH2O

  • 激酶实验

  • 细胞实验

    0 - 200 μM

  • 动物实验

    ≤60 mg/kg 腹腔注射

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Banerji U, et al. Cancer Chemother Pharmacol. 2008, 62(5), 769-778.
    [2] Harland, S.J., et al. 1984. Cancer Res. 44: 1693-1697.
    [3] Smith, I.E., et al. 1985. Cancer Treat Rep. 69: 43-46.
    [4] Smith, I.E. and Evans, B.D. 1985. Cancer Treat. Rev. 12: 73-75.
    [5] Lokich, J. 2001. Cancer Invest. 19: 756-760.

    分子式
    C6H12N2O4Pt    		 分子量
    371.25    		 CAS号
    41575-94-4    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    <1 mg/mL    		 Water
    >10 mg/mL    		 Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02137928 Retinoblastoma Drug: carboplatin periocular injection|Drug: chemotherapy Sun Yat-sen University Phase 3 2006-01-01 2014-12-18
    NCT01261299 Carcinoma, Non-Small-Cell Lung|Urinary Bladder Neoplasms Drug: Carbon-14-labeled carboplatin University of California, Davis|Lawrence Livermore National Laboratory|National Institutes of Health (NIH) Early Phase 1 2010-12-01 2017-03-21
    NCT00230542 Ovarian Cancer|Peritoneal Cancer|Fallopian Tube Cancer Drug: Carboplatin|Drug: Pemetrexed Dana-Farber Cancer Institute|Massachusetts General Hospital|Brigham and Women's Hospital Phase 2 2005-09-01 2017-03-22
    NCT02279992 Glioma|Brain Neoplasms|Brain Metastasis Drug: Vardenafil|Drug: Carboplatin Cedars-Sinai Medical Center Early Phase 1 2011-05-01 2015-10-21
    NCT02103244 Cancer Drug: Carboplatin Rijnstate Hospital Phase 4 2014-09-01 2014-04-02
    NCT00889018 Intraocular Retinoblastoma Drug: carboplatin|Drug: carboplatin All India Institute of Medical Sciences, New Delhi|Council of Scientific and Industrial Research, India 2009-04-01 2012-02-07
    NCT01051362 Non-small Cell Lung Cancer Drug: PLD and Carboplatin The First Affiliated Hospital of Guangzhou Medical University Phase 2 2006-02-01 2010-01-15
    NCT02199171 FIGO Stage IIC-IV Ovarian Carcinoma|Fallopian Tube Carcinoma|Peritoneal Carcinoma Drug: carboplatin University of California, Irvine Phase 1 2014-07-01 2014-09-17
    NCT02035345 Recurrent Ovarian Cancer|Platinum Sensitive Ovarian Cancer Drug: Carboplatin Massachusetts General Hospital Phase 4 2014-01-01 2016-11-01
    NCT02339753 Pediatric Solid Tumor Drug: Carboplatin The Korean Society of Pediatric Hematology Oncology Phase 2 2015-01-01 2015-01-15
    NCT00675545 Hormone-Refractory Prostate Cancer Drug: Docetaxel, Carboplatin National University Hospital, Singapore Phase 2 2007-05-01 2012-03-30
    NCT01542047 Cancer, Metastatic Drug: Carboplatin|Drug: Pazopanib New Mexico Cancer Care Alliance|GlaxoSmithKline Phase 1 2012-08-01 2015-06-17
    NCT02734069 Lung Cancer|Sarcopenia|Toxicity Drug: Carboplatin Instituto Nacional de Cancerologia de Mexico 2016-02-01 2016-04-11
    NCT01178112 Advanced Cancers Drug: Trientine|Drug: Carboplatin|Drug: Trientine MTD|Drug: Carboplatin MTD|Other: PK Testing M.D. Anderson Cancer Center Phase 1 2010-07-01 2015-11-16
    NCT00702962 Small Cell Lung Cancer Drug: Vorinostat, Carboplatin, Etoposide|Other: SAHA Milton S. Hershey Medical Center|Merck Sharp & Dohme Corp. Phase 1|Phase 2 2008-09-01 2017-01-26
    NCT02133625 Advanced Solid Tumor|Metastatic Solid Tumor Drug: carboplatin|Drug: pioglitazone Dana-Farber Cancer Institute Phase 1 2011-08-01 2016-05-12
    NCT02684227 Endometrial Cancer Drug: Enzalutamide|Drug: Carboplatin|Drug: Paclitaxel M.D. Anderson Cancer Center|Astellas Pharma Inc|Medivation, Inc.|National Comprehensive Cancer Network Phase 2 2016-08-01 2016-12-01
    NCT01644955 Adult Anaplastic Astrocytoma|Adult Anaplastic Oligodendroglioma|Recurrent Adult Brain Tumor Drug: carboplatin|Procedure: Surgery James Elder|Ohio State University Comprehensive Cancer Center Phase 1 2012-06-01 2016-07-19
    NCT02941523 Cancer Drug: NOX66|Drug: Carboplatin Noxopharm Limited Phase 1|Phase 2 2017-03-03 2017-03-04
    NCT00362817 Brain Tumor|Brain Metastases Drug: carboplatin|Drug: temozolomide Ohio State University Comprehensive Cancer Center Phase 1|Phase 2 2004-10-01 2015-05-04
    NCT00735878 Non Small Cell Lung Cancer|Advanced Lung Cancer Drug: ABT-751 and Carboplatin Dartmouth-Hitchcock Medical Center|Abbott Phase 1|Phase 2 2004-09-01 2009-04-29

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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