TAME是后期促进复合物(APC)抑制剂。
TAME is an APC inhibitor. It also acts as substrate for thrombin, trypsin, plasminogen (plasmin), and other proteases. Competitive inhibitor of the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C); promotes Cdc20 autoubiquitination. It inhibits cyclin proteolysis in mitotic Xenopus oocyte extracts (IC50 = 12 μM) and blocks cyclin degradation in interphase extract.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Zeng X, et al. Cancer Cell, 2010, 18(4), 382-395.
[2] Zeng & King (2012) An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination. Nat.Chem.Biol. 8 383.
分子式 C14H23ClN4O4S |
分子量 378.87 |
CAS号 1784-03-8 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 100 mM |
Water 50 mg/mL |
Ethanol 100 mM |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT02118727 | Amyotrophic Lateral Sclerosis|Frontal Temporal Dementia | Drug: Memantine|Drug: Placebo (for Memantine) | University of Kansas Medical Center | Phase 2 | 2017-07-01 | 2017-01-23 |
NCT02015312 | Light Chain (AL) Amyloidosis|Cardiac Involvement | Drug: Epigallocatechin-3-gallate (EGCG)|Drug: Placebo | Florian Michel|German Federal Ministry of Education and Research|University Hospital Heidelberg | Phase 2 | 2013-04-01 | 2016-12-09 |
NCT02879136 | Parkinson's Disease, Idiopathic | Drug: Methylphenidate|Other: Physical Therapy|Drug: Atomoxetine | Shnehal Patel|The Cleveland Clinic | Early Phase 1 | 2016-12-01 | 2017-01-09 |
NCT02554435 | Physical Activity | Device: EAM|Behavioral: 5 A's counseling|Device: Pedometer | The University of Texas Medical Branch, Galveston|American Heart Association | 2016-01-01 | 2016-09-12 | |
NCT02656017 | Polycystic Kidney, Autosomal Dominant | Drug: Metformin|Other: Placebo | University of Pittsburgh|Tufts Medical Center|University of Maryland|University of Southern California|United States Department of Defense | Phase 2 | 2016-05-01 | 2017-02-01 |
NCT01020331 | Amyotrophic Lateral Sclerosis | Drug: Memantine | Phoenix Neurological Associates, LTD|Forest Laboratories | Phase 2 | 2005-06-01 | 2009-11-23 |
NCT01820130 | Heart Failure | Device: St Jude Medical EON mini rechargeable system | St. Jude Medical | 2013-03-01 | 2015-10-26 | |
NCT01027039 | Glaucoma | Wills Eye | 2008-06-01 | 2016-11-08 | ||
NCT01938027 | Rectal Cancer | Procedure: Transanal total mesorectal excision | National Cancer Center, Korea | 2013-09-01 | 2015-03-25 | |
NCT02932657 | Cystic Fibrosis | Other: Non interventional study | Nantes University Hospital | 2017-05-01 | 2017-02-28 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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