TAME HCl

TAME,TAME hydrocloride

TAME是后期促进复合物(APC)抑制剂。

目录号
EY0904
EY0904
EY0904
EY0904
纯度
99.42%
99.42%
99.42%
99.42%
规格
5 mg
10 mg
50 mg
100 mg
原价
302
495
960
1520
售价
302
495
960
1520
库存
现货
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    TAME is an APC inhibitor. It also acts as substrate for thrombin, trypsin, plasminogen (plasmin), and other proteases. Competitive inhibitor of the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C); promotes Cdc20 autoubiquitination. It inhibits cyclin proteolysis in mitotic Xenopus oocyte extracts (IC50 = 12 μM) and blocks cyclin degradation in interphase extract.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Zeng X, et al. Cancer Cell, 2010, 18(4), 382-395.
    [2] Zeng & King (2012) An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination. Nat.Chem.Biol. 8 383.

    分子式
    C14H23ClN4O4S
    分子量
    378.87
    CAS号
    1784-03-8
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    100 mM
    Water
    50 mg/mL
    Ethanol
    100 mM

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02118727 Amyotrophic Lateral Sclerosis|Frontal Temporal Dementia Drug: Memantine|Drug: Placebo (for Memantine) University of Kansas Medical Center Phase 2 2017-07-01 2017-01-23
    NCT02015312 Light Chain (AL) Amyloidosis|Cardiac Involvement Drug: Epigallocatechin-3-gallate (EGCG)|Drug: Placebo Florian Michel|German Federal Ministry of Education and Research|University Hospital Heidelberg Phase 2 2013-04-01 2016-12-09
    NCT02879136 Parkinson's Disease, Idiopathic Drug: Methylphenidate|Other: Physical Therapy|Drug: Atomoxetine Shnehal Patel|The Cleveland Clinic Early Phase 1 2016-12-01 2017-01-09
    NCT02554435 Physical Activity Device: EAM|Behavioral: 5 A's counseling|Device: Pedometer The University of Texas Medical Branch, Galveston|American Heart Association 2016-01-01 2016-09-12
    NCT02656017 Polycystic Kidney, Autosomal Dominant Drug: Metformin|Other: Placebo University of Pittsburgh|Tufts Medical Center|University of Maryland|University of Southern California|United States Department of Defense Phase 2 2016-05-01 2017-02-01
    NCT01020331 Amyotrophic Lateral Sclerosis Drug: Memantine Phoenix Neurological Associates, LTD|Forest Laboratories Phase 2 2005-06-01 2009-11-23
    NCT01820130 Heart Failure Device: St Jude Medical EON mini rechargeable system St. Jude Medical 2013-03-01 2015-10-26
    NCT01027039 Glaucoma Wills Eye 2008-06-01 2016-11-08
    NCT01938027 Rectal Cancer Procedure: Transanal total mesorectal excision National Cancer Center, Korea 2013-09-01 2015-03-25
    NCT02932657 Cystic Fibrosis Other: Non interventional study Nantes University Hospital 2017-05-01 2017-02-28

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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