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Isoprenaline HCl

盐酸异丙肾上腺素,NCI-c55630,Isoproterenol HCl,Isuprel,Isadrine,Euspiran,Proternol,NSC37745,NSC89747

Isoprenaline hydrochloride是非选择性的β-肾上腺素受体激动剂，与肾上腺素相似。

目录号
EY0883
EY0883
纯度
99.11%
99.11%
规格
50 mg
100 mg
原价
120
200
售价
120
200
库存
现货
现货
订购
订购
订购
订购
订购
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  • 生物活性

    Isoprenaline is a non-selective beta-adrenergic receptor agonist, used for the treatment of bradycardia and heart block. Isoproterenol hydrochloride is a phenethylamine derivative and selective β-AR adrenergic agonist shown to increase cytosolic cAMP. Exhibits promotion of glycogen breakdown and causes bronchodilation and vasorelaxant effects. Also potentially stimulates relaxation in nitric oxide mediated endothelium-dependent smooth muscle. Isoproterenol Hydrochloride is an activator of β2-AR and ERK.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Degerman E, et al. Proc Natl Acad Sci U S A, 1990, 87(2), 533-537.
    [2] Ladenheim, R.G., et al. 1993. J. Neurochem. 60: 260-266.
    [3] Macaulay, S.L., et al. 1994. Mol. Cell Biochem. 141: 27-33.
    [4] Kishimoto, I., et al. 1994. J. Biol. Chem. 269: 28300-28308.
    [5] Takemura, H., et al. 1995. J. Pharmacol. Exp. Ther. 274: 584-588.
    [6] Schmitt, J.M. and Stork, P.J. 2000. J. Biol. Chem. 275: 25342-25350.

    分子式
    C11H18ClNO3    		 分子量
    247.72    		 CAS号
    51-30-9    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    50 mg/mL    		 Water
    50 mg/mL    		 Ethanol
    20 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01377636 Intraoperative Awareness Drug: Isoproterenol New York University School of Medicine 2009-08-01 2015-02-17
    NCT00226551 Coronary Disease Drug: Isoproterenol Hadassah Medical Organization 1999-08-01 2008-10-28
    NCT00624416 Lipoma Drug: Prednisolone synthetic cortisone and Isoproterenol together Pennington Biomedical Research Center|Lipothera Phase 1|Phase 2 2007-10-01 2015-12-17
    NCT03019081 Anorexia Nervosa Drug: Isoproterenol|Other: placebo Laureate Institute for Brain Research, Inc.|Brain & Behavior Research Foundation 2017-01-01 2017-01-10
    NCT03032965 Atrial Fibrillation Drug: Adenosine|Drug: Isoproterenol University of Michigan Phase 2 2011-10-01 2017-01-23
    NCT00083395 Arrhythmic Right Ventricular Cardiomyopathy National Institutes of Health Clinical Center (CC) 2004-05-01 2008-03-03
    NCT02673996 Postural Tachycardia Syndrome Drug: Phenylephrine|Drug: Isoproterenol University of Calgary 2016-01-01 2016-08-15
    NCT02615119 Major Depressive Disorder|Anorexia Nervosa|Generalized Anxiety Disorder|Panic Disorder|Brain Injury Drug: Isoproterenol|Drug: Normal saline Laureate Institute for Brain Research, Inc. 2015-10-01 2017-02-02
    NCT02286934 Healthy Drug: Carvedilol|Other: Isoproterenol Sensitivity Test Seoul National University Hospital|National Institute of Food and Drug Safety Evaluation, Korea Phase 1 2014-09-01 2015-06-02
    NCT00428428 Kidney Stone|Unexplained Haematuria|Benignant Tumour Mass in the Upper Urinary Tract Drug: Isoproterenol Fredericia Hosptial Phase 2|Phase 3 2007-02-01 2007-11-15
    NCT00323843 Kidney Stone|Ureteroscopy Drug: Isoproterenol Fredericia Hosptial Phase 2 2006-06-01 2007-01-29
    NCT02725060 Postural Orthostatic Tachycardia Syndrome|Postural Tachycardia Syndrome|Tachycardia|Arrhythmias, Cardiac|Autonomic Nervous System Diseases|Orthostatic Intolerance|Cardiovascular Diseases|Primary Dysautonomias Drug: phenylephrine|Drug: isoproterenol|Radiation: 25 micro-Ci of radiation|Procedure: Posture study with blood samples|Procedure: 24-hour heart rhythm and blood pressure monitoring|Procedure: Quantitative Axonal Sudomotor Reflex Testing|Procedure: Autonomic function tests Vanderbilt University|University of Oklahoma 2016-02-01 2016-10-14
    NCT02524145 Heart Failure Other: Static Handgrip|Drug: Dexmedetomidine|Drug: Glycopyrrolate|Drug: Isoproterenol University of Texas Southwestern Medical Center 2013-03-01 2016-05-10
    NCT01708655 Cystic Fibrosis Other: Sweat Evaporimeter measurement University of Colorado, Denver|Cystic Fibrosis Foundation Therapeutics 2011-12-01 2014-12-01
    NCT01538277 Atrial Fibrillation|Burden of Atrial Fibrillation Procedure: Contact Force during ablation|Other: Standard ablation procedure University of Aarhus Phase 2 2012-02-01 2016-10-27
    NCT02586883 Idiopathic Dilation of the Bronchi Other: bronchial ddp test Assistance Publique - H么pitaux de Paris 2016-04-01 2016-12-02
    NCT00945347 Cystic Fibrosis Drug: Miglustat|Drug: Placebo Cliniques universitaires Saint-Luc- Universit茅 Catholique de Louvain Phase 2 2009-07-01 2011-08-09
    NCT01002534 Cystic Fibrosis Drug: Vardenafil|Drug: Placebo Cliniques universitaires Saint-Luc- Universit茅 Catholique de Louvain Phase 2 2011-10-01 2012-06-06
    NCT00782782 Congestive Heart Failure Hadassah Medical Organization 2008-08-01 2008-10-28
    NCT00537602 Cystic Fibrosis Drug: miglustat|Drug: placebo Actelion Phase 2 2007-11-01 2010-02-11
    NCT00742092 Cystic Fibrosis Drug: miglustat|Drug: placebo Actelion Phase 2 2008-08-01 2014-03-05
    NCT01079715 Retinopathy of Prematurity Drug: Propranolol Azienda Ospedaliero, Universitaria Meyer|Ospedale Maggiore Policlinico Mangiagalli e Regina Elena Phase 2|Phase 3 2010-01-01 2012-11-24

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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