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Apocynin

罗布麻宁,乙酰香草酮,茶叶花宁,Acetovanillone

Apocynin是一种选择性NADPH氧化酶抑制剂，IC50 为10 μM.

目录号
EY0861
EY0861
纯度
99.26%
99.26%
规格
100 mg
500 mg
原价
200
300
售价
200
300
库存
现货
现货
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  • 生物活性

    Apocynin is a methoxy-substituted catechol that is commonly used as an inhibitor of Mox and Nox (NADPH oxidase) (IC50=10 μM). Because of Abocynin’s inhibition of NADPH oxidase, ROS production is also inhibited. Studies show the compound’s ability to decrease superoxide generation in bovine pulmonary arteries as well as neutrophils and macrophages (10 mM). In experimental rats, apocynin has displayed anti-inflammatory activity and can improve endothelial function by reducing oxidative stress and improved NO bioavailability. Reportedly prevents phagocytosis of MBP (myelin) by macrophages. Also has proven to be a useful product for studying NO-regulated processes in plants.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Stolk J,et al. Am J Respir Cell Mol Biol, 1994, 11(1), 95-102.
    [2] Tossi, V., et al. 2009. Plant Signal Behav. 4: 880-882.
    [3] Castor, L.R., et al. 2010. Free Radic Biol Med. 15: 1636-1643.

    分子式
    C9H10O3    		 分子量
    166.17    		 CAS号
    498-02-2    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    100 mM    		 Water
    <1 mg/mL    		 Ethanol
    100 mM

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00992667 Bronchial Asthma Drug: Apocynin nebulization Medical Universtity of Lodz|Ministry of Science and Higher Education, Poland Phase 1 2008-06-01 2009-10-08
    NCT01402297 Chronic Obstructive Pulmonary Disease Drug: Apocynin and placebo nebulization Medical Universtity of Lodz|Ministry of Science and Higher Education, Poland Phase 1 2010-10-01 2011-07-25

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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