Home > RAAS & > Perindopril Erbumine

Perindopril Erbumine

培哚普利,S9490-3 培哚普利叔丁胺; Perindopril tert-butylamine salt; S-9490 erbumine

Perindopril erbumine 是长效血管紧张素转换酶（ACE）抑制剂。

目录号
EY0828
EY0828
EY0828
纯度
99.07%
99.07%
99.07%
规格
100 mg
200 mg
500 mg
原价
580.00_
980
1500
售价
580.00_
980
1500
库存
现货
现货
现货
订购
订购
订购
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  • 生物活性

    Perindopril Erbumine is a potent ACE inhibitor with IC50 of 1.05 nM. Inhibition of this enzyme prevents the formation of angiotensin II from angiotensin I, which in turn prevents vasoconstriction caused by angiotensin II. Angiotensin-converting enzyme (ACE) inhibitor (IC50 = 1.05 nM).

  • 体外研究

  • 体内研究

    Saline

  • 激酶实验

  • 细胞实验

  • 动物实验

    1 或 2 mg/kg/day口服

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Ceconi C, et al. Eur J Pharmacol, 2007, 577(1-3), 1-6.
    [2] Dong et al (2011) Perindopril, a centrally active angiotensin-converting enzyme inhibitor, prevents cognitive impairment in mouse models of Alzheimer's disease. FASEB J. 25 2911.
    [3] Takai et al (2004) Significant target organs for hypertension and cardiac hypertrophy by angiotensin-converting enzyme inhibitors. Hypertens.Res. 27 213.

    分子式
    C23H43N3O5    		 分子量
    441.6    		 CAS号
    107133-36-8    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    >10 mg/mL    		 Water
    ≥88 mg/mL    		 Ethanol
    50 mM

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02651415 Metastatic Colorectal Cancer Drug: Regorafenib|Drug: Perindopril British Columbia Cancer Agency|Bayer Phase 2 2016-08-01 2016-12-15
    NCT01013155 Essential Hypertension Drug: perindopril erbumine Roxane Laboratories 2007-05-01 2009-11-12
    NCT01012687 Essential Hypertension Drug: perindopril erbumine Roxane Laboratories 2007-04-01 2009-11-12
    NCT00461903 Essential Hypertension|Atrial Fibrillation Drug: Perindopril Montreal Heart Institute|Servier Phase 3 2007-12-01 2015-12-11
    NCT01682577 Healthy Drug: Perindopril 4 mg tablets of PT Dexa Medica|Drug: Perindopril 4 mg tablets of Servier Dexa Medica Group 2008-09-01 2012-09-06
    NCT02777489 Obesity Drug: Perindopril Gene PreDiT|Blueclinical Ltd Phase 2 2016-02-01 2017-03-07
    NCT02213224 Nonalcoholic Fatty Liver Disease (NAFLD) Drug: Perindopril|Drug: Telmisartan|Drug: Amlodipine Nanfang Hospital of Southern Medical University Phase 4 2014-08-01 2014-08-08
    NCT02729441 Diabetes|Microalbuminuria Drug: ramipril|Drug: perindopril Sunnybrook Health Sciences Centre|Servier Phase 3 2010-04-01 2016-03-31
    NCT01948232 Childhood Cancer Survivors Drug: Perindopril The Hospital for Sick Children Phase 2 2013-09-01 2015-10-02
    NCT02299310 Chronic Kidney Disease Drug: Valsartan|Drug: Perindopril Chinese PLA General Hospital Phase 4 2014-11-01 2014-11-29
    NCT01556997 Essential Hypertension Drug: XOMA 985|Drug: Amlodipine Besylate|Drug: Perindopril Erbumine Symplmed Pharmaceuticals LLC Phase 3 2012-02-01 2015-09-08
    NCT01101009 Hypertension Drug: Perindopril + amlodipine + if necessary, hydrochlorothiazide|Drug: olmesartan/amlodipine + hydrochlorothiazide, if necessary. Daiichi Sankyo Europe, GmbH|Daiichi Sankyo Inc. Phase 4 2010-04-01 2013-01-14
    NCT02655029 Adherence to Medication Regime|Hypertensive Disease Drug: Perindopril/Indapamide/Amlodipine fixed dose combination Servier Hellas Pharmaceuticals Ltd. 2015-11-25 2017-03-23
    NCT01062451 Methamphetamine Dependence|Methamphetamine Abuse|Substance Abuse Drug: Perindopril|Drug: Placebo|Drug: Candesartan Baylor College of Medicine|National Institute on Drug Abuse (NIDA) Phase 1 2009-05-01 2016-09-27
    NCT01118520 Abdominal Aortic Aneurysm Drug: perindopril arginine|Drug: amlodipine 5mgs|Drug: placebo Imperial College London|National Institute for Health Research, United Kingdom Phase 2 2011-09-01 2015-08-04
    NCT02995954 Hypertension Drug: Perindopril/Amlodipine Guido Iaccarino|Azienda Ospedaliera OO.RR. S. Giovanni di Dio e Ruggi D'Aragona Phase 4 2014-01-01 2016-12-16
    NCT01295047 Marfan Syndrome Drug: Atenolol|Drug: VERAPAMIL|Drug: Perindopril Cardiff University Phase 4 2006-07-01 2011-02-11
    NCT00202592 Hypertension Drug: Perindopril Institut de Recherches Internationales Servier|Servier Phase 2 2003-11-01 2011-06-15
    NCT00202553 Hypertension Drug: Perindopril Institut de Recherches Internationales Servier|Servier Phase 2 2003-07-01 2011-06-15

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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