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生物活性
Luteolin is a falconoid compound, which exhibits anticancer properties. It inhibits rat liver cytosolic glutathione S-transferase activity and soybean and reticulocyte 15-LO (15-lipoxygenases). Luteolin also shows cytotoxic effects on Raji lymphoma cells. Incubation of the non-tumor cell line C3H10T½CL8 with luteolin results in induction of p53 accumulation and apoptosis, with apoptosis occurring at the G2/M phase of the cell cycle. Luteolin is an inhibitor of Cot, PDE1-5, c-Src, HDAC, Maltase-glucoamylase, Topo I, PKC ε, Fatty Acid Synthase, PPAR γ and MMP.
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体外研究
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体内研究
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激酶实验
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细胞实验
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动物实验
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不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）
|  动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 |
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例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。
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参考文献
[1] Yu MC, et al. Eur J Pharmacol, 2010, 627(1-3), 269-275.
[2] Ramanathan, R., et al. 1994. Free Radic. Biol. Med. 16: 43-48.
[3] Shimoi, L., et al. 1994. Carcinogenesis. 15: 2669-2672.
[4] Plaumann, B., et al. 1996. Oncogene. 13: 1605-1614.
[5] Korkina, L.G. and Afanasev, I.B. 1997. Adv. Pharmacol. 38: 151-163.
分子式
C15H10O6 |
分子量
286.24 |
CAS号
491-70-3 |
储存方式
﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂（常温）
|
DMSO
50 mM |
Water
<1 mg/mL |
Ethanol
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体内溶解度
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Clinical Trial Information ( data from http://clinicaltrials.gov )
| NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
| NCT01847521 | Autism Spectrum Disorders | Dietary Supplement: Luteolin, Quercetin and Rutin combined in a capsule | Attikon Hospital | Phase 2 | 2011-12-01 | 2013-05-02 |
| NCT01971723 | Supplement | Other: T+ Supplement|Other: Placebo | Florida State University|East Carolina University | | 2013-06-01 | 2016-02-01 |
| NCT02909686 | Gulf War Illness | Dietary Supplement: Boswellia Serrata|Dietary Supplement: Curcumin|Dietary Supplement: Epimedium|Dietary Supplement: Fisetin|Dietary Supplement: Luteolin|Dietary Supplement: Nettle|Dietary Supplement: Pycnogenol|Dietary Supplement: Reishi Mushroom|Dietary Supplement: Resveratrol|Dietary Supplement: Placebo | University of Alabama at Birmingham|Congressionally Directed Medical Research Programs | Phase 2 | 2016-07-01 | 2016-09-16 |
注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。
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