Home > Topoisomerase & > Mitoxantrone HCl

Mitoxantrone HCl

盐酸米托蒽醌,NSC-301739

Mitoxantrone HCl是II型拓扑异构酶抑制剂，有抗肿瘤活性。

目录号
EY0761
EY0761
EY0761
纯度
99.23%
99.23%
99.23%
规格
10 mg
25 mg
50 mg
原价
200
300
400
售价
200
300
400
库存
现货
现货
现货
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  • 生物活性

    Mitoxantrone dihydrochloride is a potent inhibitor of topoisomerase II. Induces DNA damage by intercalating into DNA and inhibiting Topo II (topoisomerase II). Mitoxantrone dihydrochloride induces interstrand DNA cross-links and DNA-protein cross-links in cellular systems. Mitoxantrone dihydrochloride has recently been shown to be an inhibitor of DNA methylation.

  • 体外研究

  • 体内研究

    Saline

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Seitz M. Curr Opin Rheumatol, 1999, 11(3), 226-232.
    [2] Mitoxantrone and ametantrone induce interstrand cross-links in DNA of tumour cells: A. Skladanowski & J. Konopa; Br. J. Cancer 82, 1300 (2000)
    [3] A molecular understanding of mitoxantrone-DNA adduct formation: effect of cytosine methylation and flanking sequences: B.S. Parker, et al.; J. Biol. Chem. 279, 18814 (2004)

    分子式
    C22H30Cl2N4O6    		 分子量
    517.4    		 CAS号
    70476-82-3    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    88 mg/mL     		Water
    88 mg/mL     		Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02043756 Neoplasms Drug: Mitoxantrone Hydrochloride Liposome|Drug: Mitoxantrone CSPC ZhongQi Pharmaceutical Technology Co., Ltd. Phase 1 2011-08-01 2014-01-21
    NCT02597387 Relapsed DLBCL and PT/NKCLs Drug: Mitoxantrone HCL Liposome Injection CSPC ZhongQi Pharmaceutical Technology Co., Ltd. Phase 2 2015-08-01 2015-11-04
    NCT00203073 Relapsing Remitting Multiple Sclerosis Drug: glatiramer acetate 20 mg|Drug: glatiramer acetate 20 mg, with mitoxantrone Teva Pharmaceutical Industries Phase 2 2003-06-01 2011-04-13
    NCT00882076 Leukemia Drug: Etoposide, Mitoxantrone, Clofarabine|Drug: Clofarabine, Etoposide, Mitoxantrone Milton S. Hershey Medical Center Phase 1 2009-03-01 2014-12-04
    NCT01842672 Acute Lymphoblastic Leukemia|Acute Myelogenous Leukemia|Lymphoblastic Lymphoma|Diffuse Large B-cell Lymphoma|Burkitt Lymphoma/Leukemia Drug: Clofarabine|Drug: Mitoxantrone New York Medical College Phase 1|Phase 2 2013-03-01 2016-07-29
    NCT00660036 Acute Myeloid Leukemia Drug: Gemtuzumab ozogamicin|Drug: Mitoxantrone|Drug: Etoposide University of Pittsburgh Phase 1 2008-09-01 2016-01-14
    NCT00268242 Leukemia Drug: Gemcitabine Hydrochloride|Drug: Mitoxantrone Hydrochloride The Cleveland Clinic|National Cancer Institute (NCI)|Duke University Phase 2 2006-01-01 2015-08-30
    NCT00059631 Prostate Cancer Drug: Mitoxantrone (Novantrone)|Drug: Bortezomib (PS-341) M.D. Anderson Cancer Center|Millennium Pharmaceuticals, Inc.|National Cancer Institute (NCI) Phase 1 2003-03-01 2015-06-19
    NCT01627938 Multiple Sclerosis Drug: Dexrazoxane (DRZ) plus Mitoxantrone (MX)|Drug: Placebo plus Mitoxantrone (MX) PD Dr. Andrew Chan|Ruhr University of Bochum Phase 2 2012-04-01 2014-11-04
    NCT02021825 Neuromyelitis Optica|Neuromyelitis Optica Spectrum Disorders Drug: Mitoxantrone Xuanwu Hospital, Beijing Phase 4 2009-03-01 2013-12-19
    NCT01594918 Metastatic Castration-resistant Prostate Cancer Drug: Cabazitaxel|Drug: Mitoxantrone|Drug: Prednisone|Drug: Pegfilgrastim Rahul Aggarwal|Sanofi|University of California, San Francisco Phase 1 2012-06-01 2016-10-24
    NCT02131688 Malignant Lymphoma Drug: Mitoxantrone Hydrochloride Liposome CSPC ZhongQi Pharmaceutical Technology Co., Ltd. Phase 1 2013-05-01 2014-05-04
    NCT00661492 Androgen-independent Prostate Cancer Drug: cetuximab|Drug: Mitoxantrone US Oncology Research|ImClone LLC|Oregon Health and Science University Phase 2 2008-05-01 2016-10-13
    NCT00940524 Leukemia|Acute Lymphoblastic Leukemia Drug: Dasatinib, Mitoxantrone, Cytarabine Memorial Sloan Kettering Cancer Center|Bristol-Myers Squibb Phase 1 2009-07-01 2014-04-09
    NCT00447473 Prostatic Neoplasms Drug: GM-CSF|Drug: Ketoconazole|Drug: Mitoxantrone The Methodist Hospital System|Bayer Phase 2 2006-07-01 2016-03-15
    NCT01214317 Multiple Sclerosis Procedure: plasmapheresis Isfahan University of Medical Sciences 2010-01-01 2011-08-16
    NCT00901927 Follicular Lymphoma Drug: Bendamustine|Drug: Mitoxantrone|Drug: Rituximab M.D. Anderson Cancer Center|Cephalon Phase 2 2009-05-01 2016-05-26
    NCT02597153 Relapsed Cutaneous T Cell Lymphom Drug: Mitoxantrone HCL Liposome Injection CSPC ZhongQi Pharmaceutical Technology Co., Ltd. Phase 2 2015-10-01 2015-11-03
    NCT00003858 Prostate Cancer Drug: mitoxantrone hydrochloride Alliance for Clinical Trials in Oncology|National Cancer Institute (NCI) Phase 2 null 2016-07-12
    NCT01839240 Adult Acute Megakaryoblastic Leukemia (M7)|Adult Acute Monoblastic Leukemia (M5a)|Adult Acute Monocytic Leukemia (M5b)|Adult Acute Myeloblastic Leukemia With Maturation (M2)|Adult Acute Myeloblastic Leukemia Without Maturation (M1)|Adult Acute Myeloid Leukemia in Remission|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Adult Acute Myelomonocytic Leukemia (M4)|Adult Erythroleukemia (M6a)|Adult Pure Erythroid Leukemia (M6b)|Recurrent Adult Acute Myeloid Leukemia|Secondary Acute Myeloid Leukemia|Untreated Adult Acute Myeloid Leukemia Drug: azacitidine|Drug: cytarabine|Drug: mitoxantrone hydrochloride|Other: laboratory biomarker analysis University of Chicago|National Cancer Institute (NCI) Phase 1 2012-06-01 2016-10-24

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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