Aspirin可作为止痛剂,也能通过抑制Cox-1起到抗炎作用。
Aspirin is an antiinflammatory compound that inhibits NFκB, cylooxygenase-1 (Cox-1), and cyclooxygenase-2 (Cox-2). NFκB is a transcription factor that plays an important role in the expression of cellular and viral genes, which regulate the inflammatory response and infection. Adhesion molecules IL-1 and IL-6 are genes regulated by NFκB. Along with sodium salicylate, aspirin has been shown to block the long terminal repeat from the human immunodeficiency virus and the Ig κ enhancer from NFκB dependent transcription. Research indicates that aspirin acts at a site downstream of glutamate receptors and blocks induction of NFκB mediated by glutamate.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Kopp E, et al. Science, 1994, 265(5174), 956-959.
[2] Grilli, M., et al. 1996. Science. 274: 1383-1385.
[3] Yin, M.J., et al. 1998. Nature. 396: 77-80.
[4] Iglesias-Serret, D., et al. 2010. Apoptosis. 15: 219-229.
分子式 C9H8O4 |
分子量 180.16 |
CAS号 50-78-2 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 40 mg/mL |
Water <1 mg/mL |
Ethanol 40 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01375400 | Ischemic Stroke | Drug: Aspirin|Biological: blood sample | Central Hospital, Nancy, France | 2010-12-01 | 2011-06-20 | |
NCT01597375 | Asthma, Aspirin-Induced|Aspirin Exacerbated Asthma | Drug: Prasugrel | Elliot Israel, MD|Brigham and Women's Hospital | 2012-08-01 | 2017-01-04 | |
NCT02409680 | Premature Birth | Drug: Low dose aspirin|Drug: Placebo | NICHD Global Network for Women's and Children's Health|Thomas Jefferson University|KLE University's Jawaharlal Nehru Medical College | 2016-03-01 | 2016-12-15 | |
NCT02158806 | Venous Leg Ulcer | Drug: Aspirin|Drug: Placebo | University of Auckland, New Zealand|Health Research Council, New Zealand | Phase 3 | 2015-03-01 | 2016-05-10 |
NCT03049085 | Coronary Artery Disease|Aspirin | Drug: Aspirin|Drug: vitamin C | Medinet Heart Centre | Phase 4 | 2017-02-01 | 2017-02-07 |
NCT01361620 | Platelet Dysfunction Due to Aspirin | Drug: aspirin | George Washington University | 2007-12-01 | 2013-10-29 | |
NCT01353144 | Peptic Ulcer | Drug: aspirin | Kaohsiung Veterans General Hospital. | Phase 4 | 2007-06-01 | 2016-09-12 |
NCT02301286 | Colon Cancer|Adjuvant Therapy | Drug: Acetylsalicylic acid|Drug: Placebo Acetylsalicylic acid | Leiden University Medical Center|Stichting voor Patienten met Kanker aan het Spijsverteringskanaal (SPKS)|Dutch Colorectal Cancer Group|Stichting Geriatrische Oncologie Nederland (GeriOnNe)|Fonds NutsOhra|Innovatiefonds Zorgverzekeraars|Anticancer Fund, Belgium | Phase 3 | 2014-09-01 | 2016-03-16 |
NCT02895113 | Diabetes | Drug: Aspirin|Other: Placebo | University of Roma La Sapienza | Phase 3 | 2017-01-01 | 2016-09-08 |
NCT00470561 | Mammographic Breast Density | Drug: Aspirin|Drug: Placebo | Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) | 2005-11-01 | 2010-11-10 | |
NCT00948987 | Aspirin Resistance|Pharmacological Aspirin Non-responsiveness | Drug: Aspirin | University of Pennsylvania|National Institutes of Health (NIH)|Bayer | Phase 1 | 2004-09-01 | 2009-10-14 |
NCT02350543 | Hematuria|Urinary Bladder Neoplasms | Drug: Aspirin | Rabin Medical Center | Phase 4 | 2015-02-01 | 2016-10-08 |
NCT00818337 | Heart Disease | Drug: Aspirin | Creighton University | Phase 4 | 2008-11-01 | 2012-11-06 |
NCT02084615 | Hernia, Inguinal|Postoperative Complications|Postoperative Hemorrhage | Drug: Aspirin | Jesse Brown VA Medical Center | 2014-08-01 | 2015-06-16 | |
NCT02209909 | Coronary Artery Disease | Drug: aspirin continuation|Drug: aspirin discontinuation | Seoul National University Hospital | 2014-07-01 | 2016-04-20 | |
NCT02674958 | Hypertrophic Obstructive Cardiomyopathy | Drug: Aspirin | Ottawa Heart Institute Research Corporation | Phase 3 | 2016-05-01 | 2016-05-09 |
NCT01047722 | Healthy | Drug: Aspirin ingestion followed by doing a Bleeding Volume Test|Procedure: Gatorade Placebo followed by Bleeding Volume Test. | Klein, Jeffrey A., M.D. | Phase 1 | 2010-01-01 | 2015-07-18 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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