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Aspirin

阿司匹林,邻乙酰水杨酸,Acetylsalicylic acid,ASA,Acetylsalicylic Acid

Aspirin可作为止痛剂,也能通过抑制Cox-1起到抗炎作用。

目录号
EY0752
EY0752
EY0752
纯度
99.48%
99.48%
99.48%
规格
25 mg
50 mg
100 mg
原价
190
340
520
售价
190
340
520
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Aspirin is an antiinflammatory compound that inhibits NFκB, cylooxygenase-1 (Cox-1), and cyclooxygenase-2 (Cox-2). NFκB is a transcription factor that plays an important role in the expression of cellular and viral genes, which regulate the inflammatory response and infection. Adhesion molecules IL-1 and IL-6 are genes regulated by NFκB. Along with sodium salicylate, aspirin has been shown to block the long terminal repeat from the human immunodeficiency virus and the Ig κ enhancer from NFκB dependent transcription. Research indicates that aspirin acts at a site downstream of glutamate receptors and blocks induction of NFκB mediated by glutamate.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Kopp E, et al. Science, 1994, 265(5174), 956-959.
    [2] Grilli, M., et al. 1996. Science. 274: 1383-1385.
    [3] Yin, M.J., et al. 1998. Nature. 396: 77-80.
    [4] Iglesias-Serret, D., et al. 2010. Apoptosis. 15: 219-229.

    分子式
    C9H8O4
    分子量
    180.16
    CAS号
    50-78-2
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    40 mg/mL
    Water
    <1 mg/mL
    Ethanol
    40 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01375400 Ischemic Stroke Drug: Aspirin|Biological: blood sample Central Hospital, Nancy, France 2010-12-01 2011-06-20
    NCT01597375 Asthma, Aspirin-Induced|Aspirin Exacerbated Asthma Drug: Prasugrel Elliot Israel, MD|Brigham and Women's Hospital 2012-08-01 2017-01-04
    NCT02409680 Premature Birth Drug: Low dose aspirin|Drug: Placebo NICHD Global Network for Women's and Children's Health|Thomas Jefferson University|KLE University's Jawaharlal Nehru Medical College 2016-03-01 2016-12-15
    NCT02158806 Venous Leg Ulcer Drug: Aspirin|Drug: Placebo University of Auckland, New Zealand|Health Research Council, New Zealand Phase 3 2015-03-01 2016-05-10
    NCT03049085 Coronary Artery Disease|Aspirin Drug: Aspirin|Drug: vitamin C Medinet Heart Centre Phase 4 2017-02-01 2017-02-07
    NCT01361620 Platelet Dysfunction Due to Aspirin Drug: aspirin George Washington University 2007-12-01 2013-10-29
    NCT01353144 Peptic Ulcer Drug: aspirin Kaohsiung Veterans General Hospital. Phase 4 2007-06-01 2016-09-12
    NCT02301286 Colon Cancer|Adjuvant Therapy Drug: Acetylsalicylic acid|Drug: Placebo Acetylsalicylic acid Leiden University Medical Center|Stichting voor Patienten met Kanker aan het Spijsverteringskanaal (SPKS)|Dutch Colorectal Cancer Group|Stichting Geriatrische Oncologie Nederland (GeriOnNe)|Fonds NutsOhra|Innovatiefonds Zorgverzekeraars|Anticancer Fund, Belgium Phase 3 2014-09-01 2016-03-16
    NCT02895113 Diabetes Drug: Aspirin|Other: Placebo University of Roma La Sapienza Phase 3 2017-01-01 2016-09-08
    NCT00470561 Mammographic Breast Density Drug: Aspirin|Drug: Placebo Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) 2005-11-01 2010-11-10
    NCT00948987 Aspirin Resistance|Pharmacological Aspirin Non-responsiveness Drug: Aspirin University of Pennsylvania|National Institutes of Health (NIH)|Bayer Phase 1 2004-09-01 2009-10-14
    NCT02350543 Hematuria|Urinary Bladder Neoplasms Drug: Aspirin Rabin Medical Center Phase 4 2015-02-01 2016-10-08
    NCT00818337 Heart Disease Drug: Aspirin Creighton University Phase 4 2008-11-01 2012-11-06
    NCT02084615 Hernia, Inguinal|Postoperative Complications|Postoperative Hemorrhage Drug: Aspirin Jesse Brown VA Medical Center 2014-08-01 2015-06-16
    NCT02209909 Coronary Artery Disease Drug: aspirin continuation|Drug: aspirin discontinuation Seoul National University Hospital 2014-07-01 2016-04-20
    NCT02674958 Hypertrophic Obstructive Cardiomyopathy Drug: Aspirin Ottawa Heart Institute Research Corporation Phase 3 2016-05-01 2016-05-09
    NCT01047722 Healthy Drug: Aspirin ingestion followed by doing a Bleeding Volume Test|Procedure: Gatorade Placebo followed by Bleeding Volume Test. Klein, Jeffrey A., M.D. Phase 1 2010-01-01 2015-07-18

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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