Home > ATPase & > Digoxin

Digoxin

地高辛,12β-Hydroxydigitoxin,Lanoxin

Digoxin用来治疗不能由其他药物控制的各种心脏疾病,如心房颤动,心房扑动,及心脏衰竭。

目录号
EY0720
EY0720
纯度
99.38%
99.38%
规格
100 mg
500 mg
原价
740
1320
售价
740
1320
库存
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Digoxin is a sodium-potassium pump inhibitor, used in the treatment of atrial fibrillation and heart failure. Inhibits membrane-bound α-subunits of the Na+/K+ ATPase pump in myocytes and increases RGS2 protein levels in primary vascular smooth muscle cells through an Na+/K+ ATPase pump-dependent mechanism.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Buckalew (2005) Endogenous digitalis-like factors. An historical overview. Front.Biosci. 10 2325.
    [2] Sjogren et al (2012) Cardiotonic steroids stabilize regulator of g protein signaling 2 protein levels. Mol.Pharmacol. 82 500.
    [3] Gheorghiade et al (2004) Digoxin in the management of cardiovascular disorders. Circulation 109 2959.

    分子式
    C41H64O14
    分子量
    780.94
    CAS号
    20830-75-5
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    100 mg/mL
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01005602 Heart Failure Other: Digoxin Dosing per Nomogram|Drug: Digoxin University of Illinois at Chicago|American College of Clinical Pharmacy Phase 4 2006-12-01 2014-05-19
    NCT02167165 Atrial Fibrillation Drug: Digoxin University of Monastir 2013-07-01 2014-06-16
    NCT01582412 Pharmacokinetics of Isavuconazole|Pharmacokinetics of Digoxin|Healthy Volunteers Drug: Isavuconazole|Drug: digoxin Astellas Pharma Global Development, Inc.|Basilea Pharmaceutica International Ltd|Astellas Pharma Inc Phase 1 2012-03-01 2015-08-31
    NCT01147718 Diabetes Mellitus, Type 2 Biological: digoxin plus albiglutide GlaxoSmithKline Phase 1 2010-06-01 2016-11-30
    NCT01134965 Healthy Drug: Flibanserin plus Digoxin|Drug: Digoxin Boehringer Ingelheim Phase 1 2010-06-01 2011-04-07
    NCT02797145 Heart Failure Drug: Digoxin dose-adjusted|Drug: Standard dose Hospital Ana Nery Phase 2|Phase 3 2016-05-01 2016-06-10
    NCT02544815 Acute Heart Failure Drug: Digoxin|Drug: Placebo University of Monastir Phase 3 2016-03-01 2016-04-01
    NCT02212639 Kaposi' s Sarcoma|Classic Kaposi' s Sarcoma|Endemic Kaposi' s Sarcoma|Lymph Angio Proliferations Drug: digoxin Assistance Publique - H么pitaux de Paris Phase 2 2014-09-01 2016-04-15
    NCT02277249 Abortion, Induced Drug: Digoxin (transvaginal administration)|Drug: Digoxin (transabdominal administration) University of California, Los Angeles 2012-10-01 2016-11-28
    NCT01306175 Healthy Drug: Digoxin plus BI 10773|Drug: Digoxin Boehringer Ingelheim Phase 1 2011-02-01 2014-05-16
    NCT01357811 Healthy Volunteer Drug: eliglustat; digoxin|Drug: digoxin Genzyme, a Sanofi Company|Sanofi Phase 1 2011-08-01 2015-03-19
    NCT01796093 Heart Failure|Atrial Fibrillation Drug: Digoxin and ivabradine Cocco, Giuseppe, M.D.|Cardiology Office, Rheinfelden, Switzerland 2008-04-01 2017-01-30
    NCT01398371 Heart Failure Drug: Withdrawal of digoxin|Drug: Digoxin The Alfred 2011-08-01 2016-05-30
    NCT00831506 Alzheimer Disease|Huntington Disease Drug: digoxin|Drug: digoxin|Drug: dimebon Pfizer|Medivation, Inc. Phase 1 2009-02-01 2009-06-09
    NCT01519128 Healthy Drug: Treatment A: Digoxin|Drug: Treatment B: TMC278 Janssen R&D Ireland Phase 1 2012-01-01 2013-03-01
    NCT01663961 Healthy Drug: YM178 OCAS|Drug: Digoxin Astellas Pharma Europe B.V.|Astellas Pharma Inc Phase 1 2008-09-01 2015-08-31
    NCT01103622 Type 2 Diabetes Mellitus Drug: AZD1656|Drug: Digoxin|Drug: Placebo AstraZeneca Phase 1 2010-06-01 2011-01-04
    NCT02451527 Healthy Drug: Digoxin|Drug: PEX168 First Affiliated Hospital Xi'an Jiaotong University Phase 1 2015-05-01 2016-11-28

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

  • 相关化合物库

  • 使用AMQUAR产品发表文献后请联系我们

相关推荐

X
  • 联系人 :
  • 收件地址 :
  • 电话号码 :
  • 单位名称 :
  • 产品货号 :
  • 产品规格 :
  • 发票抬头以及单位税号 :