Digoxin用来治疗不能由其他药物控制的各种心脏疾病,如心房颤动,心房扑动,及心脏衰竭。
Digoxin is a sodium-potassium pump inhibitor, used in the treatment of atrial fibrillation and heart failure. Inhibits membrane-bound α-subunits of the Na+/K+ ATPase pump in myocytes and increases RGS2 protein levels in primary vascular smooth muscle cells through an Na+/K+ ATPase pump-dependent mechanism.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Buckalew (2005) Endogenous digitalis-like factors. An historical overview. Front.Biosci. 10 2325.
[2] Sjogren et al (2012) Cardiotonic steroids stabilize regulator of g protein signaling 2 protein levels. Mol.Pharmacol. 82 500.
[3] Gheorghiade et al (2004) Digoxin in the management of cardiovascular disorders. Circulation 109 2959.
分子式 C41H64O14 |
分子量 780.94 |
CAS号 20830-75-5 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 100 mg/mL |
Water <1 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01005602 | Heart Failure | Other: Digoxin Dosing per Nomogram|Drug: Digoxin | University of Illinois at Chicago|American College of Clinical Pharmacy | Phase 4 | 2006-12-01 | 2014-05-19 |
NCT02167165 | Atrial Fibrillation | Drug: Digoxin | University of Monastir | 2013-07-01 | 2014-06-16 | |
NCT01582412 | Pharmacokinetics of Isavuconazole|Pharmacokinetics of Digoxin|Healthy Volunteers | Drug: Isavuconazole|Drug: digoxin | Astellas Pharma Global Development, Inc.|Basilea Pharmaceutica International Ltd|Astellas Pharma Inc | Phase 1 | 2012-03-01 | 2015-08-31 |
NCT01147718 | Diabetes Mellitus, Type 2 | Biological: digoxin plus albiglutide | GlaxoSmithKline | Phase 1 | 2010-06-01 | 2016-11-30 |
NCT01134965 | Healthy | Drug: Flibanserin plus Digoxin|Drug: Digoxin | Boehringer Ingelheim | Phase 1 | 2010-06-01 | 2011-04-07 |
NCT02797145 | Heart Failure | Drug: Digoxin dose-adjusted|Drug: Standard dose | Hospital Ana Nery | Phase 2|Phase 3 | 2016-05-01 | 2016-06-10 |
NCT02544815 | Acute Heart Failure | Drug: Digoxin|Drug: Placebo | University of Monastir | Phase 3 | 2016-03-01 | 2016-04-01 |
NCT02212639 | Kaposi' s Sarcoma|Classic Kaposi' s Sarcoma|Endemic Kaposi' s Sarcoma|Lymph Angio Proliferations | Drug: digoxin | Assistance Publique - H么pitaux de Paris | Phase 2 | 2014-09-01 | 2016-04-15 |
NCT02277249 | Abortion, Induced | Drug: Digoxin (transvaginal administration)|Drug: Digoxin (transabdominal administration) | University of California, Los Angeles | 2012-10-01 | 2016-11-28 | |
NCT01306175 | Healthy | Drug: Digoxin plus BI 10773|Drug: Digoxin | Boehringer Ingelheim | Phase 1 | 2011-02-01 | 2014-05-16 |
NCT01357811 | Healthy Volunteer | Drug: eliglustat; digoxin|Drug: digoxin | Genzyme, a Sanofi Company|Sanofi | Phase 1 | 2011-08-01 | 2015-03-19 |
NCT01796093 | Heart Failure|Atrial Fibrillation | Drug: Digoxin and ivabradine | Cocco, Giuseppe, M.D.|Cardiology Office, Rheinfelden, Switzerland | 2008-04-01 | 2017-01-30 | |
NCT01398371 | Heart Failure | Drug: Withdrawal of digoxin|Drug: Digoxin | The Alfred | 2011-08-01 | 2016-05-30 | |
NCT00831506 | Alzheimer Disease|Huntington Disease | Drug: digoxin|Drug: digoxin|Drug: dimebon | Pfizer|Medivation, Inc. | Phase 1 | 2009-02-01 | 2009-06-09 |
NCT01519128 | Healthy | Drug: Treatment A: Digoxin|Drug: Treatment B: TMC278 | Janssen R&D Ireland | Phase 1 | 2012-01-01 | 2013-03-01 |
NCT01663961 | Healthy | Drug: YM178 OCAS|Drug: Digoxin | Astellas Pharma Europe B.V.|Astellas Pharma Inc | Phase 1 | 2008-09-01 | 2015-08-31 |
NCT01103622 | Type 2 Diabetes Mellitus | Drug: AZD1656|Drug: Digoxin|Drug: Placebo | AstraZeneca | Phase 1 | 2010-06-01 | 2011-01-04 |
NCT02451527 | Healthy | Drug: Digoxin|Drug: PEX168 | First Affiliated Hospital Xi'an Jiaotong University | Phase 1 | 2015-05-01 | 2016-11-28 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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