Olanzapine

奥氮平,奥兰氮平,LY170053,LY170053,Zyprexa

Olanzapine是5-HT2和D2受体高亲和性拮抗剂。

目录号
EY0717
EY0717
纯度
99.38%
99.38%
规格
50 mg
100 mg
原价
480
680
售价
480
680
库存
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Olanzapine is a high affinity for 5-HT2 serotonin and D2 dopamine receptor antagonist.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Bymaster FP, et al. J Clin Psychiatry, 1997, 58, 28-36.
    [2] Moore, N.A., et al.: Curr. Opin Invest. Drugs, 2, 281 (1993)
    [3] Baldwin, D.S. and Montgomery, S.A.: Int. Clin. Psychopharmacol., 10, 239 (1995)
    [4] Tohen, M., et al.: Am. J. Psychiatry, 156, 702 (1999)

    分子式
    C17H20N4S
    分子量
    312.44
    CAS号
    132539-06-1
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    60 mg/mL
    Water
    <1 mg/mL
    Ethanol
    10 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00183404 Autism Drug: Olanzapine Drexel University|National Institute of Mental Health (NIMH) Phase 2|Phase 3 2004-09-01 2014-08-14
    NCT03066622 Headache Drug: Standard of Care as per attending physician|Drug: 5mg rapidly dissolving olanzapine HealthPartners Institute 2016-07-01 2017-02-23
    NCT01184443 Eating Disorder Drug: Olanzapine Children's Hospital of Eastern Ontario Phase 3 2010-08-01 2014-09-03
    NCT02129478 Chemotherapy-induced Nausea and Vomiting Drug: Olanzapine The Hospital for Sick Children|Pediatric Oncology Group of Ontario Phase 2 2014-03-01 2016-09-26
    NCT01625923 Idiopathic Gastroparesis Drug: Olanzapine University of Michigan|Massachusetts General Hospital 2013-01-01 2016-06-30
    NCT01503424 Fed Drug: Olanzapine Dr. Reddy's Laboratories Limited Phase 1 2011-08-01 2012-01-04
    NCT01503398 Fasting Drug: Olanzapine Dr. Reddy's Laboratories Limited Phase 1 2011-08-01 2012-01-04
    NCT00287352 Psychotic Disorder|Schizophreniform Disorder|Schizophrenia|Schizoaffective Disorder|Mood Disorders With Psychotic Features Drug: Olanzapine, Amantadine|Drug: Olanzapine and placebo University of North Carolina, Chapel Hill|Eli Lilly and Company Phase 1 2005-05-01 2011-04-29
    NCT00678457 Alcohol Dependence Drug: Ondansetron|Drug: Olanzapine|Drug: Placebo University of Virginia Phase 2 2007-01-01 2009-01-29
    NCT00275301 Borderline Personality Disorder Drug: olanzapine University of Minnesota - Clinical and Translational Science Institute|Eli Lilly and Company 2005-12-01 2011-08-25
    NCT01503450 Fed Drug: Olanzapine OD Tablets 5 mg Dr. Reddy's Laboratories Limited Phase 1 2006-11-01 2012-01-04
    NCT01503437 Fasting Drug: Olanzapine OD Tablets 5 mg Dr. Reddy's Laboratories Limited Phase 1 2006-11-01 2012-01-04
    NCT00273624 Therapy-resistant Depression Drug: Olanzapine|Drug: Placebo University Hospital Freiburg Phase 3 2005-06-01 2016-05-12
    NCT00568672 Relapse Rate of a Major Depressive Episode|Safety of Olanzapine in Subjects With Major Depression Drug: Olanzapine Charite University, Berlin, Germany|Eli Lilly and Company Phase 3 2007-10-01 2008-04-23
    NCT02435654 Early-onset Schizophrenia Drug: olanzapine Kunming Medical University|National Natural Science Foundation of China Phase 4 2015-08-01 2016-11-30
    NCT02970643 Chemotherapy-induced Nausea and Vomiting Drug: Olanzapine|Drug: Palonosetron Hee Jun Kim|CJ HealthCare Corporation|Chung-Ang University Hosptial, Chung-Ang University College of Medicine 2016-07-01 2016-11-22
    NCT00088465 Schizophrenic Disorders|Schizoaffective Disorder Drug: Intramuscular olanzapine depot Eli Lilly and Company Phase 3 2004-08-01 2011-12-09
    NCT00320489 Schizophrenia Drug: olanzapine|Drug: olanzapine pamoate depot Eli Lilly and Company Phase 3 2006-04-01 2012-01-19
    NCT00260962 Anorexia Nervosa Drug: Olanzapine Ottawa Hospital Research Institute|Eli Lilly and Company Phase 2 2000-09-01 2009-09-30
    NCT00636896 Weight Gain Drug: Olanzapine plus modafinil|Drug: Olanzapine plus placebo Neuropsychiatric Research Institute, Fargo, North Dakota|Eli Lilly and Company|University of North Dakota 2006-07-01 2008-03-10
    NCT00194064 Bipolar Disorder Drug: Olanzapine University Hospitals Cleveland Medical Center|Eli Lilly and Company Phase 3 2002-07-01 2016-10-03

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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