Chlorpromazine HCl

盐酸氯丙嗪,Sonazine

Chlorpromazine hydrochloride (盐酸氯丙嗪) 是多巴胺受体和钾离子通道抑制剂。

目录号
EY0667
EY0667
纯度
99.32%
99.32%
规格
100 mg
500 mg
原价
112
370
售价
112
370
库存
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Chlorpromazine hydrochloride is used in cell signaling and neuroscience research. It is an inhibitor of calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (PDE). Chloropromazine is also a D2DR inhibitor. The compound shows α-adrenergic blocking action. Chlorpromazine hydrochloride is an inhibitor of Eg5, Histamine H1 Receptor, NOS1 and PLA2.

  • 体外研究

  • 体内研究

    30% propylene glycol, 5% Tween 80, 65% D5W(5%葡萄糖水溶液)

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Mozrzymas JW, et al. J Neurosci, 1999, 19(7), 2474-2488.
    [2] Palacios, M., et al. 1993. Biochem. Biophys. Res. Commun. 196: 280-286.
    [3] Maor, I., et al. 1995. Arterioscler. Thromb. Vasc. Biol. 15: 1378-1387.
    [4] Netea, M.G., et al. 1995. J. Infect. Dis. 171: 393-399.
    [5] Lee, M.S., et al. 2007. Cancer Res. 67: 11359-11367.

    分子式
    C17H20Cl2N2S
    分子量
    355.33
    CAS号
    69-09-0
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    50 mg/mL
    Water
    50 mg/mL
    Ethanol
    50 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02943213 Anti-Psychotic|Management of Manifestations of Psychotic Disorders|Treatment of Schizophrenia|Control Nausea and Vomiting|Relief of Restlessness and Apprehension Before Surgery|Acute Intermittent Porphyria|Adjunct in the Treatment of Tetanus|Control Manifestations of the Manic Type of Mani-depressive Illness|Relief of Intractable Hiccups Drug: Chlorpromazine Hydrochloride Cycle Pharmaceuticals Ltd.|Parexel Phase 1 2016-11-01 2016-12-13
    NCT03021486 Malignant Neoplasms of Independent (Primary) Multiple Sites Drug: Haloperidol|Drug: Chlorpromazine|Behavioral: Symptom Questionnaire M.D. Anderson Cancer Center|National Institutes of Health (NIH) Phase 2|Phase 3 2017-05-01 2017-03-23
    NCT01404364 Blind Painful Eye|Refractory Glaucoma|Control of Pain Through Drug Injection Drug: Triamcinolone|Drug: Chlorpromazine Hospital Governador Celso Ramos 2010-01-01 2011-07-27
    NCT00202293 Bipolar Disorder|Schizoaffective Disorder Drug: Olanzapine|Drug: Lithium|Drug: Chlorpromazine Melbourne Health Phase 4 2001-10-01 2015-11-18
    NCT00169039 Schizophrenia Drug: Clozapine|Drug: Chlorpromazine Harvard Medical School|National Institute of Mental Health (NIMH)|Dartmouth-Hitchcock Medical Center|Commonwealth Research Center, Massachusetts|Novartis Phase 4 1994-12-01 2015-04-06
    NCT00882518 Schizophrenia Drug: Quetiapine Fumarate (SEROQUEL) Extended-Release (XR)|Drug: Chlorpromazine AstraZeneca Phase 3 2009-04-01 2012-04-16
    NCT01509885 Spinal Cord Injuries|Muscle Spasticity University of Alberta 2010-07-01 2012-11-16
    NCT02810782 Neonatal Abstinence Syndrome Drug: Phenobarbital|Drug: Chlorpromazine|Drug: Morphine University of Zurich Phase 3 2001-06-01 2016-06-28
    NCT00654576 Schizophrenia Drug: Chlorpromazine, Sulpiride, Clozapine, Olanzapine, Risperidone, Quetiapine, Aripitrazole|Behavioral: psychosocial intervention Central South University|Shanghai Mental Health Center|Sichuan University|Capital Medical University|Nanjing Medical University|Jiangxi Mental Hospital|Hunan Mental Hospital|Guangzhou Mental Hospital|Chongqing Metal Institute|Henan Mental Hospital Phase 4 2005-02-01 2008-04-07
    NCT01016145 Schizophrenia or Schizoaffective Disorder Drug: Antipsychotics|Drug: Antipsychotics University of Sao Paulo Phase 4 2009-04-01 2009-11-18
    NCT01561742 Schizophrenia Drug: Minocycline|Drug: Placebo The University of Texas Health Science Center, Houston|Stanley Medical Research Institute 2012-02-01 2012-03-22
    NCT01547026 Schizophrenia|Schizo-affective Disorder Behavioral: Implementation Intentions University of Konstanz|Center for Psychiatry, Reichenau, Germany|Thurgau Psychiatric Services, Switzerland 2012-04-01 2013-02-12
    NCT00678691 Fibromyalgia, Primary Drug: armodafinil|Drug: placebo State University of New York - Upstate Medical University Phase 4 2007-08-01 2014-12-09
    NCT03019887 Schizophrenia Relapse Drug: risperidone, haloperidol, olanzapine, quetiapine, aripiprazole, paliperidone, levomepromazine, perphenazine Juntendo University 2011-04-01 2017-01-14
    NCT01594749 Chemotherapy-Induced Nausea and Vomiting (CINV) Drug: Fosaprepitant dimeglumine|Drug: Fosaprepitant Placebo|Drug: Dexamethasone|Drug: Ondansetron|Drug: Dexamethasone Placebo|Drug: Ondansetron Placebo|Drug: Rescue Therapy Merck Sharp & Dohme Corp. Phase 3 2012-09-01 2017-02-17
    NCT02582736 Psychotic Disorders|Schizophrenia|Schizoaffective Disorder|Bipolar Disorder|Diabetes Mellitus, Type 2 Drug: Olanzapine|Drug: Risperidone|Drug: atypical antipsychotics (other)|Drug: typical antipsychotics Canadian Network for Observational Drug Effect Studies, CNODES|Drug Safety and Effectiveness Network, Canada|Canadian Institutes of Health Research (CIHR) 2012-04-01 2015-10-20

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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