Chlorpromazine hydrochloride (盐酸氯丙嗪) 是多巴胺受体和钾离子通道抑制剂。
Chlorpromazine hydrochloride is used in cell signaling and neuroscience research. It is an inhibitor of calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (PDE). Chloropromazine is also a D2DR inhibitor. The compound shows α-adrenergic blocking action. Chlorpromazine hydrochloride is an inhibitor of Eg5, Histamine H1 Receptor, NOS1 and PLA2.
30% propylene glycol, 5% Tween 80, 65% D5W(5%葡萄糖水溶液)
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Mozrzymas JW, et al. J Neurosci, 1999, 19(7), 2474-2488.
[2] Palacios, M., et al. 1993. Biochem. Biophys. Res. Commun. 196: 280-286.
[3] Maor, I., et al. 1995. Arterioscler. Thromb. Vasc. Biol. 15: 1378-1387.
[4] Netea, M.G., et al. 1995. J. Infect. Dis. 171: 393-399.
[5] Lee, M.S., et al. 2007. Cancer Res. 67: 11359-11367.
分子式 C17H20Cl2N2S |
分子量 355.33 |
CAS号 69-09-0 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 50 mg/mL |
Water 50 mg/mL |
Ethanol 50 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT02943213 | Anti-Psychotic|Management of Manifestations of Psychotic Disorders|Treatment of Schizophrenia|Control Nausea and Vomiting|Relief of Restlessness and Apprehension Before Surgery|Acute Intermittent Porphyria|Adjunct in the Treatment of Tetanus|Control Manifestations of the Manic Type of Mani-depressive Illness|Relief of Intractable Hiccups | Drug: Chlorpromazine Hydrochloride | Cycle Pharmaceuticals Ltd.|Parexel | Phase 1 | 2016-11-01 | 2016-12-13 |
NCT03021486 | Malignant Neoplasms of Independent (Primary) Multiple Sites | Drug: Haloperidol|Drug: Chlorpromazine|Behavioral: Symptom Questionnaire | M.D. Anderson Cancer Center|National Institutes of Health (NIH) | Phase 2|Phase 3 | 2017-05-01 | 2017-03-23 |
NCT01404364 | Blind Painful Eye|Refractory Glaucoma|Control of Pain Through Drug Injection | Drug: Triamcinolone|Drug: Chlorpromazine | Hospital Governador Celso Ramos | 2010-01-01 | 2011-07-27 | |
NCT00202293 | Bipolar Disorder|Schizoaffective Disorder | Drug: Olanzapine|Drug: Lithium|Drug: Chlorpromazine | Melbourne Health | Phase 4 | 2001-10-01 | 2015-11-18 |
NCT00169039 | Schizophrenia | Drug: Clozapine|Drug: Chlorpromazine | Harvard Medical School|National Institute of Mental Health (NIMH)|Dartmouth-Hitchcock Medical Center|Commonwealth Research Center, Massachusetts|Novartis | Phase 4 | 1994-12-01 | 2015-04-06 |
NCT00882518 | Schizophrenia | Drug: Quetiapine Fumarate (SEROQUEL) Extended-Release (XR)|Drug: Chlorpromazine | AstraZeneca | Phase 3 | 2009-04-01 | 2012-04-16 |
NCT01509885 | Spinal Cord Injuries|Muscle Spasticity | University of Alberta | 2010-07-01 | 2012-11-16 | ||
NCT02810782 | Neonatal Abstinence Syndrome | Drug: Phenobarbital|Drug: Chlorpromazine|Drug: Morphine | University of Zurich | Phase 3 | 2001-06-01 | 2016-06-28 |
NCT00654576 | Schizophrenia | Drug: Chlorpromazine, Sulpiride, Clozapine, Olanzapine, Risperidone, Quetiapine, Aripitrazole|Behavioral: psychosocial intervention | Central South University|Shanghai Mental Health Center|Sichuan University|Capital Medical University|Nanjing Medical University|Jiangxi Mental Hospital|Hunan Mental Hospital|Guangzhou Mental Hospital|Chongqing Metal Institute|Henan Mental Hospital | Phase 4 | 2005-02-01 | 2008-04-07 |
NCT01016145 | Schizophrenia or Schizoaffective Disorder | Drug: Antipsychotics|Drug: Antipsychotics | University of Sao Paulo | Phase 4 | 2009-04-01 | 2009-11-18 |
NCT01561742 | Schizophrenia | Drug: Minocycline|Drug: Placebo | The University of Texas Health Science Center, Houston|Stanley Medical Research Institute | 2012-02-01 | 2012-03-22 | |
NCT01547026 | Schizophrenia|Schizo-affective Disorder | Behavioral: Implementation Intentions | University of Konstanz|Center for Psychiatry, Reichenau, Germany|Thurgau Psychiatric Services, Switzerland | 2012-04-01 | 2013-02-12 | |
NCT00678691 | Fibromyalgia, Primary | Drug: armodafinil|Drug: placebo | State University of New York - Upstate Medical University | Phase 4 | 2007-08-01 | 2014-12-09 |
NCT03019887 | Schizophrenia Relapse | Drug: risperidone, haloperidol, olanzapine, quetiapine, aripiprazole, paliperidone, levomepromazine, perphenazine | Juntendo University | 2011-04-01 | 2017-01-14 | |
NCT01594749 | Chemotherapy-Induced Nausea and Vomiting (CINV) | Drug: Fosaprepitant dimeglumine|Drug: Fosaprepitant Placebo|Drug: Dexamethasone|Drug: Ondansetron|Drug: Dexamethasone Placebo|Drug: Ondansetron Placebo|Drug: Rescue Therapy | Merck Sharp & Dohme Corp. | Phase 3 | 2012-09-01 | 2017-02-17 |
NCT02582736 | Psychotic Disorders|Schizophrenia|Schizoaffective Disorder|Bipolar Disorder|Diabetes Mellitus, Type 2 | Drug: Olanzapine|Drug: Risperidone|Drug: atypical antipsychotics (other)|Drug: typical antipsychotics | Canadian Network for Observational Drug Effect Studies, CNODES|Drug Safety and Effectiveness Network, Canada|Canadian Institutes of Health Research (CIHR) | 2012-04-01 | 2015-10-20 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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