Oritavancin has multiple mechanisms of action, including inhibition of transglycosylation, inhibition of transpeptidation, and cell membrane interaction/disruption.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
分子式 C86H97Cl3N10O26 · 2H3PO4 |
分子量 1989.09 |
CAS号 192564-14-0 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO |
Water |
Ethanol |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01784536 | Healthy | Drug: Single-Dose IV Oritavancin Diphosphate | The Medicines Company | Phase 1 | 2013-01-01 | 2013-04-16 |
NCT02340988 | Healthy | Drug: Single-Dose IV Oritavancin Diphosphate and Warfarin|Drug: Single-Dose IV Oritavancin Diphosphate and Warfarin 24 hour post dose | The Medicines Company | Phase 1 | 2015-04-01 | 2015-11-02 |
NCT01762839 | Healthy | Drug: Single-Dose IV Oritavancin Diphosphate|Drug: Placebo|Drug: Moxifloxacin | The Medicines Company | Phase 1 | 2013-01-01 | 2013-04-16 |
NCT01252719 | Wound Infection|Abscess|Systemic Inflammation|Cellulitis | Drug: Single-Dose IV Oritavancin Diphosphate|Drug: IV Vancomycin | The Medicines Company | Phase 3 | 2010-12-01 | 2012-11-09 |
NCT01252732 | Wound Infection|Abscess|Systemic Inflammation|Cellulitis | Drug: Single-Dose IV Oritavancin Diphosphate|Drug: IV Vancomycin | The Medicines Company | Phase 3 | 2010-12-01 | 2013-06-25 |
NCT02134301 | Gram Positive Bacterial Infections | Drug: Oritavancin | The Medicines Company | Phase 1 | 2014-05-01 | 2015-11-04 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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