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Dalbavancin

Zeven

目录号
EY3014
EY3014
EY3014
EY3014
纯度
99.02%
99.02%
99.02%
99.02%
规格
1 mg
5 mg
10 mg
50 mg
原价
510
1350
2500
7500
售价
510
1350
2500
7500
库存
现货
现货
现货
现货
订购
订购
订购
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  • 生物活性

    Dalbavancin is a semi-synthetic glycopeptide prepared from A40926 by introducing a positively charged lipophilic moiety in a previously unexplored region of the natural glycopeptide. This modification provides a longer in vitro half life, and improved in vitro activity against a variety of Gram positive and multi-drug resistant isolates such as MRSA and MRSE.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    分子式
    C88H100Cl2N10O28    		 分子量
    1816.69    		 CAS号
    171500-79-1    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    		 Water
    		 Ethanol

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02940730 Infectious Peritonitis Drug: Dalbavancin via Intravenous Administration|Drug: Dalbavancin via Intraperitoneal Administration University of Colorado, Denver Phase 4 2017-04-01 2017-03-02
    NCT02688790 Bacterial Infections Drug: Dalbavancin Durata Therapeutics Inc., an affiliate of Allergan plc Phase 1 2016-04-01 2016-10-19
    NCT02127970 Abscess|Wound Infection|Surgical Site Infection|Cellulitis Drug: Single Dose Dalbavancin|Drug: Two Dose Dalbavancin Durata Therapeutics Inc., an affiliate of Allergan plc Phase 3 2014-04-01 2016-05-11
    NCT01946568 Bacterial Infections. Drug: Dalbavancin Durata Therapeutics Inc., an affiliate of Allergan plc Phase 1 2013-06-01 2015-06-22
    NCT02344511 Osteomyelitis Drug: Dalbavancin|Drug: cefazolin, nafcillin, oxacillin or vancomycin Durata Therapeutics International BV (an Affiliate of Actavis, Inc.)|Durata Therapeutics Inc., an affiliate of Allergan plc Phase 3 2016-03-01 2016-09-22
    NCT03091439 Osteomyelitis Drug: Dalbavancin|Drug: Comparator Allergan Phase 2 2017-04-20 2017-03-21
    NCT02685033 Osteomyelitis Drug: Dalbavancin|Drug: Comparator Durata Therapeutics Inc., an affiliate of Allergan plc Phase 2 2016-03-01 2016-10-18
    NCT00678106 Bacterial Infections Drug: Dalbavancin Pfizer Phase 1 2008-09-01 2009-10-09
    NCT01339091 Abscess|Wound Infection|Surgical Site Infection|Cellulitis Drug: Dalbavancin|Drug: Vancomycin / Linezolid Durata Therapeutics Inc., an affiliate of Allergan plc Phase 3 2011-03-01 2013-12-26
    NCT01431339 Abscess|Wound Infection|Surgical Site Infection|Cellulitis Drug: IV Dalbavancin|Drug: Vancomycin/Linezolid Durata Therapeutics Inc., an affiliate of Allergan plc Phase 3 2011-07-01 2013-12-27
    NCT02814916 Methicillin-Resistant Staphylococcus Aureus|Bacterial Infections|Staphylococcal Skin Infections Drug: Dalbavancin single dose|Drug: Dalbavancin two dose|Drug: Comparator Durata Therapeutics Inc., an affiliate of Allergan plc Phase 3 2016-06-01 2016-06-23
    NCT00057369 Bacteremia Drug: dalbavancin Vicuron Pharmaceuticals Phase 2 2001-02-01 2005-06-23
    NCT02269644 Community Acquired Pneumonia Drug: Dalbavancin|Drug: Linezolid|Drug: Linezolid Placebo|Drug: Azithromycin Durata Therapeutics Inc., an affiliate of Allergan plc Phase 3 2015-11-01 2016-01-21
    NCT02961764 Acute Bacterial Skin and Skin Structure Infections Drug: Usual Care|Drug: Dalbavancin Allergan Phase 4 2016-11-01 2016-12-09

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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