A synthetic gonadotropin inhibitor which has a preventive effect on estrogen -related endometrial carcinogenesis in mice. Danazol therapy has also shown regression of established mammary carcinoma in rats.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Kinga Viktória Kőhalmi,et al. Evaluation of a Nanoemulsion Formulation Strategy for Oral Bioavailability Enhancement of Danazol in Rats and Dogs. Orphanet J Rare Dis. 2016; 11: 18. Published online 2016 Feb 25. doi: 10.1186/s13023-016-0386-2.
[2] N. C. Hepburn, et al. Danazol-induced hypercalcaemia in alphacalcidol-treated hypoparathyroidism. Postgrad Med J. 1989 Nov; 65(769): 849–850.
[3] Kinga Viktória Kőhalmi,et al. Danazol induces apoptosis and cytotoxicity of leukemic cells alone and in combination with purine nucleoside analogs in chronic lymphocytic leukemia. Ann Hematol. 2016; 95: 425–435. Published online 2015 Dec 22. doi: 10.1007/s00277-015-2579-5.
分子式 C22H27NO2 |
分子量 337.46 |
CAS号 17230-88-5 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 30 mg/mL |
Water <1 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01001598 | Fanconi Anemia|Dyskeratosis Congenita | Drug: danazol | Boston Children Hospital | Phase 1|Phase 2 | 2009-11-01 | 2014-09-12 |
NCT01779232 | Endometriosis|Ovarian Cysts|Infertility | Drug: Danazol|Drug: placebo | Centre for Endocrinology and Reproductive Medicine, Italy | Phase 4 | 2012-10-01 | 2016-04-25 |
NCT00953771 | Thrombotic Thrombocytopenic Purpura | Drug: Danazol | Beth Israel Medical Center|Icahn School of Medicine at Mount Sinai | Phase 2 | 2008-10-01 | 2016-11-22 |
NCT01667263 | Autoimmune Thrombocytopenia | Drug: All-trance retinoid acid|Drug: Danazol | Peking University People's Hospital|Beijing Municipal Science & Technology Commission|Beijing Hospital|Qilu Hospital|Navy General Hospital, Beijing|Beijing Tongren Hospital | Phase 2 | 2012-06-01 | 2017-02-24 |
NCT01732445 | Anemia|Primary Myelofibrosis|Secondary Myelofibrosis | Drug: ruxolitinib phosphate|Drug: danazol|Other: quality-of-life assessment|Other: questionnaire administration | Mayo Clinic|National Cancer Institute (NCI) | Phase 2 | 2013-04-01 | 2016-08-25 |
NCT00003946 | Endometrial Cancer | Drug: danazol | Gynecologic Oncology Group|National Cancer Institute (NCI) | Phase 2 | 1999-08-01 | 2013-06-07 |
NCT00744276 | Fibrocystic Disease of Breast | Drug: danazol|Drug: Placebo | FemmePharma Global Healthcare, Inc. | Phase 2 | 2007-01-01 | 2010-05-25 |
NCT01441037 | Aplastic Anemia | Drug: Danazol | National Heart, Lung, and Blood Institute (NHLBI)|National Institutes of Health Clinical Center (CC) | Phase 1|Phase 2 | 2011-07-15 | 2017-01-24 |
NCT01821677 | Diabetic Macular Edema | Drug: Low Dose Danazol|Drug: Placebo | Ampio Pharmaceuticals. Inc. | Phase 3 | 2013-02-01 | 2016-05-04 |
NCT01162941 | Thrombocytopenia | Other: Steroid refractory ITP | Cooperative Study Group A for Hematology | Phase 2 | 2010-02-01 | 2010-07-14 |
NCT02002403 | Diabetic Macular Edema | Drug: Danazol | St. Michael's Hospital, Toronto | Phase 2 | 2011-01-01 | 2013-12-05 |
NCT01105793 | Moderate to Severe Cyclic Mastalgia | Drug: Danazol | FemmePharma Global Healthcare, Inc. | Phase 2 | 2010-06-01 | 2011-10-25 |
NCT00758953 | Endometriosis | Drug: Danazol Once Weekly|Drug: Danazol Twice Weekly|Drug: Placebo Once Weekly|Drug: Placebo Twice Weekly | Lumara Health, Inc. | Phase 2 | 2007-02-01 | 2012-03-02 |
NCT02556411 | Adenomyosis|Chronic Pelvic Pain | Drug: LNG-IUS 13,5 mg Levonorgestrel|Drug: Levonorgestrel 0,10 mg+ ethinylestradiol 0,02 mg | University of Cagliari | 2016-06-01 | 2016-03-08 | |
NCT02201719 | Adenomyosis | Oslo University Hospital|Helse Sor-Ost | 2014-07-01 | 2016-09-14 | ||
NCT02197923 | Adenomyosis | Procedure: Myometrial biopsy|Procedure: endometrial biopsy | Oslo University Hospital|University of Oslo|Helse Sor-Ost | 2014-07-01 | 2016-09-14 | |
NCT02599077 | Endometriosis | Drug: Dienogest|Drug: Levonorgestrel | Fundaci贸n Santa Fe de Bogota | Phase 2|Phase 3 | 2015-11-01 | 2016-11-21 |
NCT00155051 | Endometriosis | National Taiwan University Hospital | 2004-07-01 | 2005-09-09 | ||
NCT01071954 | Thrombocytopenia in Pediatric Subjects With Immune (Idiopathic) Thrombocytopenic Purpura (ITP) | Biological: Romiplostim | Amgen | Phase 3 | 2009-12-01 | 2017-01-25 |
NCT01438840 | Chronic Thrombocytopenia|Immune Thrombocytopenia | Drug: Avatrombopag|Drug: Placebo|Drug: Standard of care | Eisai Inc. | Phase 3 | 2012-02-01 | 2016-12-12 |
NCT01773187 | Primary Myelofibrosis|Post-polycythemia Vera Myelofibrosis|Post-essential Thrombocythemia Myelofibrosis | Drug: Pacritinib|Drug: Best Available Therapy | CTI BioPharma | Phase 3 | 2012-12-01 | 2016-12-15 |
NCT02055781 | Primary Myelofibrosis|Post-polycythemia Vera Myelofibrosis|Post-essential Thrombocythemia Myelofibrosis | Drug: Pacritinib|Drug: Best Available Therapy | CTI BioPharma | Phase 3 | 2013-12-01 | 2016-12-15 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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