Danazol

目录号
EY2829
EY2829
EY2829
纯度
98.75%
98.75%
98.75%
规格
50 mg
100 mg
250 mg
原价
260
500
940
售价
260
500
940
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    A synthetic gonadotropin inhibitor which has a preventive effect on estrogen -related endometrial carcinogenesis in mice. Danazol therapy has also shown regression of established mammary carcinoma in rats.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Kinga Viktória Kőhalmi,et al. Evaluation of a Nanoemulsion Formulation Strategy for Oral Bioavailability Enhancement of Danazol in Rats and Dogs. Orphanet J Rare Dis. 2016; 11: 18. Published online 2016 Feb 25. doi: 10.1186/s13023-016-0386-2.
    [2] N. C. Hepburn, et al. Danazol-induced hypercalcaemia in alphacalcidol-treated hypoparathyroidism. Postgrad Med J. 1989 Nov; 65(769): 849–850.
    [3] Kinga Viktória Kőhalmi,et al. Danazol induces apoptosis and cytotoxicity of leukemic cells alone and in combination with purine nucleoside analogs in chronic lymphocytic leukemia. Ann Hematol. 2016; 95: 425–435. Published online 2015 Dec 22. doi: 10.1007/s00277-015-2579-5.

    分子式
    C22H27NO2
    分子量
    337.46
    CAS号
    17230-88-5
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    30 mg/mL
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01001598 Fanconi Anemia|Dyskeratosis Congenita Drug: danazol Boston Children Hospital Phase 1|Phase 2 2009-11-01 2014-09-12
    NCT01779232 Endometriosis|Ovarian Cysts|Infertility Drug: Danazol|Drug: placebo Centre for Endocrinology and Reproductive Medicine, Italy Phase 4 2012-10-01 2016-04-25
    NCT00953771 Thrombotic Thrombocytopenic Purpura Drug: Danazol Beth Israel Medical Center|Icahn School of Medicine at Mount Sinai Phase 2 2008-10-01 2016-11-22
    NCT01667263 Autoimmune Thrombocytopenia Drug: All-trance retinoid acid|Drug: Danazol Peking University People's Hospital|Beijing Municipal Science & Technology Commission|Beijing Hospital|Qilu Hospital|Navy General Hospital, Beijing|Beijing Tongren Hospital Phase 2 2012-06-01 2017-02-24
    NCT01732445 Anemia|Primary Myelofibrosis|Secondary Myelofibrosis Drug: ruxolitinib phosphate|Drug: danazol|Other: quality-of-life assessment|Other: questionnaire administration Mayo Clinic|National Cancer Institute (NCI) Phase 2 2013-04-01 2016-08-25
    NCT00003946 Endometrial Cancer Drug: danazol Gynecologic Oncology Group|National Cancer Institute (NCI) Phase 2 1999-08-01 2013-06-07
    NCT00744276 Fibrocystic Disease of Breast Drug: danazol|Drug: Placebo FemmePharma Global Healthcare, Inc. Phase 2 2007-01-01 2010-05-25
    NCT01441037 Aplastic Anemia Drug: Danazol National Heart, Lung, and Blood Institute (NHLBI)|National Institutes of Health Clinical Center (CC) Phase 1|Phase 2 2011-07-15 2017-01-24
    NCT01821677 Diabetic Macular Edema Drug: Low Dose Danazol|Drug: Placebo Ampio Pharmaceuticals. Inc. Phase 3 2013-02-01 2016-05-04
    NCT01162941 Thrombocytopenia Other: Steroid refractory ITP Cooperative Study Group A for Hematology Phase 2 2010-02-01 2010-07-14
    NCT02002403 Diabetic Macular Edema Drug: Danazol St. Michael's Hospital, Toronto Phase 2 2011-01-01 2013-12-05
    NCT01105793 Moderate to Severe Cyclic Mastalgia Drug: Danazol FemmePharma Global Healthcare, Inc. Phase 2 2010-06-01 2011-10-25
    NCT00758953 Endometriosis Drug: Danazol Once Weekly|Drug: Danazol Twice Weekly|Drug: Placebo Once Weekly|Drug: Placebo Twice Weekly Lumara Health, Inc. Phase 2 2007-02-01 2012-03-02
    NCT02556411 Adenomyosis|Chronic Pelvic Pain Drug: LNG-IUS 13,5 mg Levonorgestrel|Drug: Levonorgestrel 0,10 mg+ ethinylestradiol 0,02 mg University of Cagliari 2016-06-01 2016-03-08
    NCT02201719 Adenomyosis Oslo University Hospital|Helse Sor-Ost 2014-07-01 2016-09-14
    NCT02197923 Adenomyosis Procedure: Myometrial biopsy|Procedure: endometrial biopsy Oslo University Hospital|University of Oslo|Helse Sor-Ost 2014-07-01 2016-09-14
    NCT02599077 Endometriosis Drug: Dienogest|Drug: Levonorgestrel Fundaci贸n Santa Fe de Bogota Phase 2|Phase 3 2015-11-01 2016-11-21
    NCT00155051 Endometriosis National Taiwan University Hospital 2004-07-01 2005-09-09
    NCT01071954 Thrombocytopenia in Pediatric Subjects With Immune (Idiopathic) Thrombocytopenic Purpura (ITP) Biological: Romiplostim Amgen Phase 3 2009-12-01 2017-01-25
    NCT01438840 Chronic Thrombocytopenia|Immune Thrombocytopenia Drug: Avatrombopag|Drug: Placebo|Drug: Standard of care Eisai Inc. Phase 3 2012-02-01 2016-12-12
    NCT01773187 Primary Myelofibrosis|Post-polycythemia Vera Myelofibrosis|Post-essential Thrombocythemia Myelofibrosis Drug: Pacritinib|Drug: Best Available Therapy CTI BioPharma Phase 3 2012-12-01 2016-12-15
    NCT02055781 Primary Myelofibrosis|Post-polycythemia Vera Myelofibrosis|Post-essential Thrombocythemia Myelofibrosis Drug: Pacritinib|Drug: Best Available Therapy CTI BioPharma Phase 3 2013-12-01 2016-12-15

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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