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Ketoprofen

酮洛芬,Actron

Ketoprofen is a non-selective NSAID with IC50 of 0.5 μM and 2.33 μM for human recombinant COX-1 and COX-2, respectively.

目录号
EY2220
EY2220
EY2220
纯度
98.85%
98.85%
98.85%
规格
50 mg
100 mg
500 mg
原价
150
200
350
售价
150
200
350
库存
现货
现货
现货
订购
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  • 生物活性

    Ketoprofen is a non-selective NSAID with IC50 of 0.5 μM and 2.33 μM for human recombinant COX-1 and COX-2, respectively.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Phedias Diamandis et. al. Chemical genetics reveals a complex functional ground state of neural stem cells. Nature Chemical Biology, 3(5), 268-273 (2007)
    [2] D Marini et. al. Randomised trial of the bioavailability and efficacy of orally administered flunixin, carprofen and ketoprofen in a pain model in sheep. Australian Veterinary Journal, 93(8), 265-270 (2015).
    [3] Julia Martín et. al. Pharmaceutically active compounds in sludge stabilization treatments: anaerobic and aerobic digestion, wastewater stabilization ponds and composting. Science of The Total Environment, 503-504, 97-104 (2015).

    分子式
    C16H14O3    		 分子量
    254.28    		 CAS号
    22071-15-4    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    50 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    50 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02730026 Pain|Other Surgical Procedures Drug: Ketoprofen|Drug: Ketoprofen and Omeprazole Luis Fernando Simoneti|Fundao de Amparo Pesquisa do Estado de So Paulo|University of Sao Paulo Phase 4 2015-06-01 2017-03-08
    NCT02491879 Mechanical Low Back Pain Drug: Ketoprofen|Other: Placebo Akdeniz University|Kocatepe University|Celal Bayar University Phase 4 2015-06-01 2015-12-02
    NCT00765700 Sprain|Strain|Acute Soft Tissue Injury Drug: Topical Ketoprofen 10% Cream|Drug: Topical Placebo Cream Imprimis Pharmaceuticals, Inc.|Cato Research Phase 3 2008-09-01 2013-09-20
    NCT00971581 Pain Drug: FDC KETOPROFEN+OMEPRAZOLE Sanofi Phase 3 2009-08-01 2010-06-28
    NCT02491736 Ankle Sprain Drug: Ketoprofen|Other: Placebo Akdeniz University Phase 4 2015-06-01 2015-12-02
    NCT02538224 Chronic Periodontitis Drug: 2.5%ketoprofen gel + 3 % doxycycline|Drug: :2.5%ketoprofen gel Islamic Azad University, Tehran Phase 2|Phase 3 2013-07-01 2016-06-03
    NCT00108810 Pain|Osteoarthritis, Knee Drug: Transdermal Ketoprofen Patch with CHADD|Drug: Placebo transdermal patch ZARS Pharma Inc. Phase 2 2005-04-01 2012-05-30
    NCT01211795 Migraine Drug: topical intraoral ketoprofen gel|Other: Placebo Gel Behar, Caren, M.D. Phase 3 2009-10-01 2011-06-04
    NCT00553605 Pain Drug: Ketoprofen 100mg|Drug: Parecoxib 40mg Pfizer Phase 4 2007-06-01 2012-12-20
    NCT02393846 Ankle Sprain Drug: Ketoprofen gel|Drug: Placebo Akdeniz University|Pamukkale University Phase 4 2015-02-01 2015-07-03
    NCT01020279 Musculoskeletal Pain Drug: Celecoxib, Ketoprofen|Drug: Ketoprofen X-pert Med GmbH Phase 1 2009-10-01 2010-06-24
    NCT02905045 Pain Relief Drug: Ketoprofen|Drug: placebo Assiut University Phase 3 2016-10-01 2016-09-16
    NCT02905058 Pain Relief Drug: Ketoprofen|Drug: placebo Assiut University Phase 3 2016-10-01 2017-03-12
    NCT00799838 Pharyngotonsillitis Drug: Ketoprofen|Drug: Placebo (for Ketoprofen)|Drug: Amoxicillin Sanofi Phase 4 2008-11-01 2014-10-23
    NCT01223053 Sprain Drug: Ketoprofen 10% cream|Drug: Placebo Imprimis Pharmaceuticals, Inc. Phase 3 2012-09-04
    NCT01228552 Migraine Disorders|Migraine Headache|Migraine|Acute Migraine Drug: Topical, intra-oral ketoprofen gel|Other: Placebo gel Behar, Caren, M.D. Phase 3 2011-12-01 2011-06-04
    NCT00557544 Migraine Drug: metoclopramide|Drug: placebo|Drug: ketoprofen IRCCS Burlo Garofolo Phase 3 2009-02-01 2009-01-28
    NCT02439034 Uterine Cervical Cancer|Upper Aerodigestive Tract Neoplasms Drug: Paracetamol|Drug: Ketoprofen Centre Oscar Lambret|SANTELYS Phase 2 2015-02-01 2016-07-27
    NCT00317733 Osteoarthritis, Knee Drug: Ketoprofen in Transfersome IDEA AG Phase 2 2009-03-19
    NCT00679146 Low Back Pain Drug: Thiocolchicoside+Ketoprofen|Drug: Thiocolchicoside Sanofi Phase 3 2008-04-01 2010-06-10
    NCT00929877 Pain Drug: KETOPROFEN(RP19583)|Drug: KETOPROFEN(RP19583)|Drug: Placebo Sanofi Phase 3 2009-06-01 2010-05-17
    NCT02619695 Low Back Pain Drug: Fastjel Akdeniz University|Pamukkale University|Celal Bayar University|Kocatepe University Phase 4 2015-06-01 2015-12-01
    NCT01890902 Acute Pain (Flare) Associated With Osteoarthritis (OA) of the Knee Drug: Ketoprofen 10% Cream|Drug: Placebo Imprimis Pharmaceuticals, Inc. Phase 3 2013-08-01 2013-11-08
    NCT01685658 Renal Colic|Acute Renal Colic Drug: Intravenous ketoprofen|Drug: Intravenous paracetamol Centre Hospitalier Universitaire de Nmes Phase 4 2016-09-01 2016-04-06
    NCT00352625 Tendonitis|Bursitis Drug: Ketoprofen Topical Patch 20% Endo Pharmaceuticals Phase 3 2006-06-01 2008-08-13

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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