动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Beguinot, L., et al. 1985. Proc. Natl. Acad. Sci. U.S.A. 82: 2774-2778. PMID: 2859591
[2] Saltis, J., et al. 1991. J. Biol. Chem. 266: 261-267. PMID: 1985898
[3] Oishi, K. and Yamaguchi, M. 1994. J. Cell. Biochem. 55: 168-172. PMID: 8089192
[4] Powell, D.J., et al. 2003. Mol. Cell. Biol. 23: 7794-7808. PMID: 14560023
[5] Shimura, C., et al. 2010. Am. J. Pathol. 176: 227-237. PMID: 20008150
分子式 C36H56O8 |
分子量 616.83 |
CAS号 16561-29-8 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 25 mg/mL |
Water <1 mg/mL |
Ethanol 25 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT00004058 | Chronic Myeloproliferative Disorders|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Diseases|Precancerous/Nonmalignant Condition | Drug: tetradecanoylphorbol acetate | University of Medicine and Dentistry of New Jersey|National Cancer Institute (NCI)|Rutgers, The State University of New Jersey | Phase 1 | 1998-12-01 | 2010-01-25 |
NCT01009931 | Leukemia | Drug: 12-O-tetradecanoylphorbol-13-acetate|Drug: Dexamethasone|Drug: Choline magnesium trisalicylate | Rutgers, The State University of New Jersey|Rutgers Cancer Institute of New Jersey|National Cancer Institute (NCI)|Biosuccess Biotech Co., Ltd. | Phase 2 | 2011-03-01 | 2015-11-02 |
NCT00204789 | Post-solid Organ Transplant|Skin Neoplasms | Drug: Difluoromethylornithine | University of Wisconsin, Madison | Phase 2 | 2003-07-01 | 2015-09-30 |
NCT01850459 | Autism Spectrum Disorders | Children's Hospital Medical Center, Cincinnati | 2013-01-01 | 2014-03-05 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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