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Tetradecanoyl phorbol acetate

phorbol acetate

目录号
EY2211
EY2211
EY2211
纯度
99.34%
99.34%
99.34%
规格
1 mg
5 mg
10 mg
原价
540
1590
2680
售价
540
1590
2680
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Beguinot, L., et al. 1985. Proc. Natl. Acad. Sci. U.S.A. 82: 2774-2778. PMID: 2859591
    [2] Saltis, J., et al. 1991. J. Biol. Chem. 266: 261-267. PMID: 1985898
    [3] Oishi, K. and Yamaguchi, M. 1994. J. Cell. Biochem. 55: 168-172. PMID: 8089192
    [4] Powell, D.J., et al. 2003. Mol. Cell. Biol. 23: 7794-7808. PMID: 14560023
    [5] Shimura, C., et al. 2010. Am. J. Pathol. 176: 227-237. PMID: 20008150

    分子式
    C36H56O8
    分子量
    616.83
    CAS号
    16561-29-8
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    25 mg/mL
    Water
    <1 mg/mL
    Ethanol
    25 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00004058 Chronic Myeloproliferative Disorders|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Diseases|Precancerous/Nonmalignant Condition Drug: tetradecanoylphorbol acetate University of Medicine and Dentistry of New Jersey|National Cancer Institute (NCI)|Rutgers, The State University of New Jersey Phase 1 1998-12-01 2010-01-25
    NCT01009931 Leukemia Drug: 12-O-tetradecanoylphorbol-13-acetate|Drug: Dexamethasone|Drug: Choline magnesium trisalicylate Rutgers, The State University of New Jersey|Rutgers Cancer Institute of New Jersey|National Cancer Institute (NCI)|Biosuccess Biotech Co., Ltd. Phase 2 2011-03-01 2015-11-02
    NCT00204789 Post-solid Organ Transplant|Skin Neoplasms Drug: Difluoromethylornithine University of Wisconsin, Madison Phase 2 2003-07-01 2015-09-30
    NCT01850459 Autism Spectrum Disorders Children's Hospital Medical Center, Cincinnati 2013-01-01 2014-03-05

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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