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Polymyxin B sulfate

Polymyxin B sulfate,Polymyxin-B sulfate

目录号
EY2207
EY2207
EY2207
纯度
99.53%
99.53%
99.53%
规格
100 mg
250 mg
500 mg
原价
150
260
480
售价
150
260
480
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Polymyxin B Sulfate是一个阳离子型表面活性剂抗生素剂,是polymyxins B1 和B2的混合物,能够提高细胞膜的渗透性。

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Shi, C., et al. 2007. Vascul. Pharmacol. 46: 406-411. PMID: 17347056
    [2] Hegemann, L., et al. 1991. Eur. J. Pharmacol. 207: 17-22. PMID: 1915592
    [3] Inaba, H. and Filkins, J.P. 1991. Am. J. Physiol. 261: R26-R31. PMID: 1858953
    [4] Tam, V.H., et al. 2005. Antimicrob. Agents Chemother. 49: 3624-3630. PMID: 16127031

    分子式
    C56H98N16O13.H2SO4
    分子量
    1301.56
    CAS号
    1405-20-5
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    <1 mg/mL
    Water
    100 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02328183 Hospital Infection Drug: Polymyxin B Mahidol University Phase 4 2014-12-01 2015-08-31
    NCT01429701 Eczema Drug: polymyxin B sulphate + prednisolone + benzocaine + clioquinol|Drug: betamethasone + gentamicin + tolnaftato + cleoquinol EMS Phase 3 2012-05-01 2013-03-01
    NCT00490477 Gram-Negative Bacterial Infections|Sepsis Device: Polymyxin -B fiber hemoperfusion system University of Turin, Italy Phase 3 2006-05-01 2010-06-04
    NCT01646229 Abdominal Sepsis|Peritonitis|Colon Perforation Other: Polymyxin-B hemoperfusion|Other: Control University Hospital, Geneva 2012-01-01 2016-05-11
    NCT02682355 Pneumonia|Blood Stream Infection University of Michigan 2016-02-01 2017-03-21
    NCT02413541 Severe Sepsis Procedure: Polymyxin-B Hemoperfusion|Procedure: Standard treatment Chulalongkorn University 2015-01-01 2016-01-26
    NCT02134106 Bacteremia|Healthcare-associated Pneumonia|Ventilator-associated Pneumonia Drug: Polymyxin B|Drug: Polymyxin B + Doripenem Tan Tock Seng Hospital|Singapore General Hospital|National University Hospital, Singapore|Changi General Hospital Phase 2|Phase 3 2015-01-01 2014-12-12
    NCT02871024 Sepsis Device: Toraymyxin National Taiwan University Hospital Phase 2 2016-08-01 2016-08-17
    NCT00534391 Hordeolum Drug: neomycin sulfate, polymyxin B sulfate and gramicidin|Drug: Artificial tear Chulalongkorn University Phase 3 2007-09-01 2010-11-22
    NCT00629382 Gram-Negative Bacterial Infections|Sepsis|Septic Shock Device: Polymyxin B immobilized fiber column|Other: Conventional medical therapy in the ICU St. Bortolo Hospital Phase 4 2004-12-01 2008-12-01
    NCT01948778 Patients in Septic Shock Device: oXiris filter|Device: Toraymyxin Filter|Device: Standard of Care University of Zurich 2013-08-01 2015-02-24
    NCT01227863 Bacterial Conjunctivitis|Acute Drug: MAXINOM|Drug: Maxitrol Azidus Brasil Phase 3 2011-02-01 2010-10-22
    NCT01222663 Peritonitis|Septic Shock Device: standard therapy|Device: hemoperfusion Meditor SAS Phase 3 2010-10-01 2013-12-17
    NCT02825329 Septic Shock|Endotoxemia Device: TORAYMYXIN PMX-20R Spectral Diagnostics (US) Inc. 2016-07-04
    NCT01046669 Septic Shock|Endotoxemia Device: TORAYMYXIN PMX-20R (PMX cartridge) Spectral Diagnostics (US) Inc. Phase 3 2010-06-01 2016-10-14
    NCT02641236 Hematopoietic Stem Cell Transplantation (HSCT)|Acute GVH Disease Drug: Vancomycin-polymyxin B Dana-Farber Cancer Institute Phase 2 2016-03-01 2016-08-11
    NCT02186457 Surgery|Infection Drug: Polymyxin B in Normal Saline|Other: Placebo: Normal Saline Indiana University 2014-11-01 2017-03-05
    NCT01756755 Sepsis Device: PMX-20R Hemoperfusion National Taiwan University Hospital Phase 4 2012-12-01 2015-02-04
    NCT02582255 Poliomyelitis Biological: Sabin mOPV2 Fidec Corporation|Bill and Melinda Gates Foundation Phase 4 2015-11-01 2015-10-19
    NCT00000635 Herpes Simplex|HIV Infections Drug: Trifluridine|Drug: Bacitracin zinc/Polymyxin B sulfate National Institute of Allergy and Infectious Diseases (NIAID)|Glaxo Wellcome 2012-03-29
    NCT02515656 Vaginitis Drug: POLYGYNAX|Drug: GYNODAKTARIN|Drug: Placebo Laboratoire Innotech International|International Clinical Trials Association|Venn Life Sciences Phase 3 2015-09-01 2016-10-18
    NCT00997139 Nasal Carriers of Staphylococcus Aureus Drug: Neosporin (polymyxin B 5,000units, bacitracin 400 units, neomycin 3.5mg) Northwestern University 2009-09-01 2014-12-11
    NCT01584271 Acute Otitis Externa Device: Natural Ear Comfort(TM), a botanical ear drops product Assuta Hospital Systems Phase 2 2011-07-01 2013-07-07
    NCT02344732 Corneal Diseases Drug: Dexamethasone 0.1%, Neomycin Sulfate and Polymyxin B Sulfate topical eye drops four times daily|Drug: Homatropine 2% eye drops thrice daily|Drug: Oxygen gas University of Science Malaysia 2013-10-01 2015-01-22
    NCT01431170 Congenital Nasolacrimal Duct Obstruction Drug: Besivance Treatment Group|Drug: Polytrim Treatment Group Rutgers, The State University of New Jersey|Bausch & Lomb Incorporated Phase 1 2011-09-01 2016-06-15

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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