Polymyxin B Sulfate是一个阳离子型表面活性剂抗生素剂,是polymyxins B1 和B2的混合物,能够提高细胞膜的渗透性。
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Shi, C., et al. 2007. Vascul. Pharmacol. 46: 406-411. PMID: 17347056
[2] Hegemann, L., et al. 1991. Eur. J. Pharmacol. 207: 17-22. PMID: 1915592
[3] Inaba, H. and Filkins, J.P. 1991. Am. J. Physiol. 261: R26-R31. PMID: 1858953
[4] Tam, V.H., et al. 2005. Antimicrob. Agents Chemother. 49: 3624-3630. PMID: 16127031
分子式 C56H98N16O13.H2SO4 |
分子量 1301.56 |
CAS号 1405-20-5 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO <1 mg/mL |
Water 100 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT02328183 | Hospital Infection | Drug: Polymyxin B | Mahidol University | Phase 4 | 2014-12-01 | 2015-08-31 |
NCT01429701 | Eczema | Drug: polymyxin B sulphate + prednisolone + benzocaine + clioquinol|Drug: betamethasone + gentamicin + tolnaftato + cleoquinol | EMS | Phase 3 | 2012-05-01 | 2013-03-01 |
NCT00490477 | Gram-Negative Bacterial Infections|Sepsis | Device: Polymyxin -B fiber hemoperfusion system | University of Turin, Italy | Phase 3 | 2006-05-01 | 2010-06-04 |
NCT01646229 | Abdominal Sepsis|Peritonitis|Colon Perforation | Other: Polymyxin-B hemoperfusion|Other: Control | University Hospital, Geneva | 2012-01-01 | 2016-05-11 | |
NCT02682355 | Pneumonia|Blood Stream Infection | University of Michigan | 2016-02-01 | 2017-03-21 | ||
NCT02413541 | Severe Sepsis | Procedure: Polymyxin-B Hemoperfusion|Procedure: Standard treatment | Chulalongkorn University | 2015-01-01 | 2016-01-26 | |
NCT02134106 | Bacteremia|Healthcare-associated Pneumonia|Ventilator-associated Pneumonia | Drug: Polymyxin B|Drug: Polymyxin B + Doripenem | Tan Tock Seng Hospital|Singapore General Hospital|National University Hospital, Singapore|Changi General Hospital | Phase 2|Phase 3 | 2015-01-01 | 2014-12-12 |
NCT02871024 | Sepsis | Device: Toraymyxin | National Taiwan University Hospital | Phase 2 | 2016-08-01 | 2016-08-17 |
NCT00534391 | Hordeolum | Drug: neomycin sulfate, polymyxin B sulfate and gramicidin|Drug: Artificial tear | Chulalongkorn University | Phase 3 | 2007-09-01 | 2010-11-22 |
NCT00629382 | Gram-Negative Bacterial Infections|Sepsis|Septic Shock | Device: Polymyxin B immobilized fiber column|Other: Conventional medical therapy in the ICU | St. Bortolo Hospital | Phase 4 | 2004-12-01 | 2008-12-01 |
NCT01948778 | Patients in Septic Shock | Device: oXiris filter|Device: Toraymyxin Filter|Device: Standard of Care | University of Zurich | 2013-08-01 | 2015-02-24 | |
NCT01227863 | Bacterial Conjunctivitis|Acute | Drug: MAXINOM|Drug: Maxitrol | Azidus Brasil | Phase 3 | 2011-02-01 | 2010-10-22 |
NCT01222663 | Peritonitis|Septic Shock | Device: standard therapy|Device: hemoperfusion | Meditor SAS | Phase 3 | 2010-10-01 | 2013-12-17 |
NCT02825329 | Septic Shock|Endotoxemia | Device: TORAYMYXIN PMX-20R | Spectral Diagnostics (US) Inc. | 2016-07-04 | ||
NCT01046669 | Septic Shock|Endotoxemia | Device: TORAYMYXIN PMX-20R (PMX cartridge) | Spectral Diagnostics (US) Inc. | Phase 3 | 2010-06-01 | 2016-10-14 |
NCT02641236 | Hematopoietic Stem Cell Transplantation (HSCT)|Acute GVH Disease | Drug: Vancomycin-polymyxin B | Dana-Farber Cancer Institute | Phase 2 | 2016-03-01 | 2016-08-11 |
NCT02186457 | Surgery|Infection | Drug: Polymyxin B in Normal Saline|Other: Placebo: Normal Saline | Indiana University | 2014-11-01 | 2017-03-05 | |
NCT01756755 | Sepsis | Device: PMX-20R Hemoperfusion | National Taiwan University Hospital | Phase 4 | 2012-12-01 | 2015-02-04 |
NCT02582255 | Poliomyelitis | Biological: Sabin mOPV2 | Fidec Corporation|Bill and Melinda Gates Foundation | Phase 4 | 2015-11-01 | 2015-10-19 |
NCT00000635 | Herpes Simplex|HIV Infections | Drug: Trifluridine|Drug: Bacitracin zinc/Polymyxin B sulfate | National Institute of Allergy and Infectious Diseases (NIAID)|Glaxo Wellcome | 2012-03-29 | ||
NCT02515656 | Vaginitis | Drug: POLYGYNAX|Drug: GYNODAKTARIN|Drug: Placebo | Laboratoire Innotech International|International Clinical Trials Association|Venn Life Sciences | Phase 3 | 2015-09-01 | 2016-10-18 |
NCT00997139 | Nasal Carriers of Staphylococcus Aureus | Drug: Neosporin (polymyxin B 5,000units, bacitracin 400 units, neomycin 3.5mg) | Northwestern University | 2009-09-01 | 2014-12-11 | |
NCT01584271 | Acute Otitis Externa | Device: Natural Ear Comfort(TM), a botanical ear drops product | Assuta Hospital Systems | Phase 2 | 2011-07-01 | 2013-07-07 |
NCT02344732 | Corneal Diseases | Drug: Dexamethasone 0.1%, Neomycin Sulfate and Polymyxin B Sulfate topical eye drops four times daily|Drug: Homatropine 2% eye drops thrice daily|Drug: Oxygen gas | University of Science Malaysia | 2013-10-01 | 2015-01-22 | |
NCT01431170 | Congenital Nasolacrimal Duct Obstruction | Drug: Besivance Treatment Group|Drug: Polytrim Treatment Group | Rutgers, The State University of New Jersey|Bausch & Lomb Incorporated | Phase 1 | 2011-09-01 | 2016-06-15 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
相关化合物库
使用AMQUAR产品发表文献后请联系我们