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Heparin

Heparin, a highly sulfated glycosaminoglycan, is widely used as an injectable anticoagulant, and has the highest negative charge density of any known biological molecule.

目录号
EY2200
EY2200
纯度
210 u/mg
210 u/mg
规格
25 mg
50 mg
原价
1650
2750
售价
1650
2750
库存
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现货
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  • 生物活性

     

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Maria C. Z. Meneghetti,et al. Heparan sulfate and heparin interactions with proteins. J R Soc Interface. 2015 Sep 6; 12(110): 20150589. doi: 10.1098/rsif.2015.0589.
    [2] Lori-Ann Linkins,et al. Treatment and Prevention of Heparin-Induced Thrombocytopenia: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012 Feb; 141(2 Suppl): e495S–e530S. Published online 2012 Jan 23. doi: 10.1378/chest.11-2303. Correction in: Chest. 2015 Dec; 148(6): 1529.
    [3] Meital Cohen-Mazor,et al. Heparin Interaction with the Primed Polymorphonuclear Leukocyte CD11b Induces Apoptosis and Prevents Cell Activation. J Immunol Res. 2015; 2015: 751014. Published online 2015 Dec 27. doi: 10.1155/2015/751014.

    分子式
    C26H42N2O37S5    		 分子量
    1134.93    		 CAS号
    9005-49-6    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    <1 mg/mL    		 Water
    10 mM    		 Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01598883 Cardiopulmonary Bypass|Altered Heparin Response Drug: Heparin|Drug: ATryn Massachusetts General Hospital|rEVO Biologics Phase 1 2012-06-01 2016-12-13
    NCT01092455 Renal Dialysis Drug: Heparin N reduction Randolph Quinn|Fresenius Medical Care North America Phase 4 2009-12-01 2011-08-31
    NCT00701623 Burns Drug: heparin|Drug: heparin|Drug: folder water Azidus Brasil Phase 2|Phase 3 2008-06-01 2010-10-26
    NCT01229072 Chronic Renal Failure Biological: Heparin sodic|Biological: heparin liquemine Azidus Brasil Phase 2|Phase 3 2008-07-01 2010-10-26
    NCT01454869 Heparin Drug: standard care|Drug: Heparin Tehran University of Medical Sciences Phase 3 2012-02-01 2012-12-14
    NCT00848796 Coronary Artery Bypass Grafting Drug: Heparin Leo and Hepalean Southlake Regional Health Centre 2006-09-01 2009-02-19
    NCT01260519 Diagnostic Coronary Angiography Drug: Heparin Prince Sultan Cardiac Center, Adult Cardiology Department. Phase 3 2008-07-01 2010-12-14
    NCT01694459 Stable Angina|Angina, Unstable|Non-ST Elevation (NSTEMI) Myocardial Infarction Drug: Low-dose heparin|Drug: Standard dose heparin San Filippo Neri General Hospital|University of Roma La Sapienza Phase 4 2010-01-01 2012-09-26
    NCT00894673 Cardiac Surgery Biological: Heparin sodium Hipolabor|Biological: Heparin sodium APP Azidus Brasil Phase 3 2009-07-01 2013-02-22
    NCT01318811 Acute Kidney Injury|Acute Renal Failure|Heart Failure Drug: Dilute unfractionated heparin|Drug: Standard concentration unfractionated heparin Vanderbilt University Phase 4 2011-03-01 2016-05-06
    NCT01363193 Obesity|Morbid Obesity|Venous Thromboembolism|Atrial Fibrillation|Angina|Chest Pain Drug: Lean Body Weight-based heparin dose Nazareth Hospital 2011-07-01 2013-05-13
    NCT02144064 Recurrent Miscarriage Drug: Heparin Benha University Phase 3 2012-06-01 2015-03-06
    NCT00587444 Postoperative Hemorrhage Drug: Heparin|Drug: HH or high heparin|Drug: heparin concentration HC Mayo Clinic|Medtronic Phase 3 2001-06-01 2009-10-14
    NCT02707263 Venous Thromboembolism Drug: intravenous continuous infusion of heparin (IV UFH)|Drug: Subcutaneous Heparin New York University School of Medicine 2016-03-01 2016-10-06
    NCT01388270 Renal Failure Device: a pre-heparin-coated hemodialysis filter; Hepran Oslo University Hospital Phase 4 2011-09-01 2016-02-03
    NCT02493504 Arteriovenous Fistula Drug: Heparin Fatemeh Hoseinzadegan|Shahid Beheshti University of Medical Sciences Phase 4 2011-01-01 2015-07-07
    NCT01823393 Aortic Stenosis, Non-rheumatic Drug: Heparin|Drug: NaCl University Hospital, Montpellier Phase 4 2013-01-01 2016-11-30
    NCT00828776 Chronic Renal Failure Biological: Heparin sodic - Cristlia|Biological: heparin - Liquemine (Roche) Azidus Brasil Phase 2|Phase 3 2007-09-01 2009-01-23
    NCT02654561 Sepsis|Disseminated Intravascular Coagulation Drug: Heparin Sodium|Drug: Saline China Medical University, China|Peking Union Medical College Hospital|West China Hospital|First Affiliated Hospital, Sun Yat-Sen University|Central South University|The Second Affiliated Hospital of Harbin Medical University|Zhongda Hospital|Zhejiang Hospital|The First Affiliated Hospital of Dalian Medical University|Shengjing Hospital Phase 3 2016-05-01 2016-01-12
    NCT00894829 Cardiac Surgery Biological: heparin sodium - Eurofarma|Biological: heparin sodium - APP Azidus Brasil Phase 3 2009-06-01 2013-02-22
    NCT02501434 Aneurysmal Subarachnoid Hemorrhage|Neurobehavioral Manifestations|Vasospasm, Intracranial|Intracranial Aneurysm|Heparin-induced Thrombocytopenia Type II Drug: Continuous Low-Dose Intravenous Unfractionated Heparin Infusion (14 days) Robert F James, MD, FACS, FAANS|University of Louisville Phase 2 2016-03-01 2016-04-15
    NCT00894998 Cardiac Surgery Biological: heparin sodium - Cristlia|Biological: Heparin sodium APP Azidus Brasil Phase 3 2009-06-01 2013-02-22
    NCT00894985 Cardiac Surgery Biological: heparin sodium - blausiegel|Biological: heparin sodium - APP Azidus Brasil Phase 3 2009-06-01 2013-02-22
    NCT01072747 Prevention of Venous Thromboembolism Biological: bovine heparin|Biological: Porcine heparin Azidus Brasil Phase 3 2010-04-01 2011-01-27
    NCT00894959 Cardiac Surgery Biological: Heparin sodium Blausiegel 1|Biological: Heparin sodium APP Azidus Brasil Phase 3 2009-07-01 2013-02-22

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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