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ML 224

ML-224,ML224,ANTAG 3,ANTAG-3,ANTAG3,NCGC 00242364,NCGC-00242364

ML 224 是促甲状腺激素受体TSHR反激动剂,IC50值为2.3uM。

目录号
EY2039
EY2039
EY2039
纯度
99.08%
99.08%
99.08%
规格
2 mg
5 mg
10 mg
原价
1105
2320
3520
售价
1105
2320
3520
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    ML 224 是促甲状腺激素受体TSHR反激动剂,IC50值为2.3uM。

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Neumann S, et al. A selective TSH receptor antagonist inhibits stimulation of thyroid function in female mice. Endocrinology. 2014 Jan;155(1):310-4.
    [2] Huang W, et al. Identification of Thyroid Stimulating Hormone Receptor Inverse Agonists. Probe Reports from the NIH Molecular Libraries Program.

    分子式
    C31H31N3O5
    分子量
    525.59
    CAS号
    1338824-21-7
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    10 mM
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00405574 Prostate Cancer Drug: ATN-224 Attenuon|Prostate Cancer Clinical Trials Consortium Phase 2 2006-11-01 2008-01-28
    NCT02508805 Vertebrogenic Radiculopathy L5, S1 Drug: Neuromultivit|Drug: Voltaren|Drug: Sirdalud Valeant Pharmaceuticals International, Inc.|Valeant Russia, LLC Phase 3 2015-05-01 2015-09-27
    NCT03072030 Ebola Virus Disease|Prevention Biological: GamEvac-Combi (vaccine)|Biological: Placebo Gamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian Federation|Military medical Academy named after S. M. Kirov Phase 4 2017-06-01 2017-03-01
    NCT02388672 Blood Pressure Dietary Supplement: decaffeinated coffee|Dietary Supplement: chlorogenic acid|Dietary Supplement: green coffee bean extract supplement|Dietary Supplement: placebo University Hospital Tuebingen 2015-03-01 2016-01-25
    NCT03063073 Breast Cancer Female Drug: Dexmedetomidine Injection [Precedex]|Drug: Bupivacaine South Egypt Cancer Institute Phase 3 2017-02-25 2017-02-23
    NCT02819843 Melanoma|Merkel Cell Carcinoma|Other Solid Tumors Drug: TALIMOGENE LAHERPAREPVEC (TVEC)|Radiation: Hypofractionated Radiotherapy Memorial Sloan Kettering Cancer Center|Amgen Phase 2 2016-06-01 2017-02-22
    NCT02663960 Critical Illness|Kidney Replacement Disorder|Coagulation; Intravascular Other: fixed citrate doses protocol|Other: adjusted citrate doses protocol Peking Union Medical College Hospital Phase 4 2015-08-01 2016-01-25
    NCT02863211 Cardiovascular Diseases|Vascular Stiffness St. Boniface General Hospital Research Centre 2015-09-01 2017-01-30
    NCT00262522 Human Immunodeficiency Virus Infections Drug: lopinavir/ritonavir (LPV/r) (tablet or capsule) with nucleoside reverse transcriptase inhibitors (NRTIs)|Drug: lopinavir/ritonavir (LPV/r) (tablet or capsule) with nucleoside reverse transcriptase inhibitors (NRTIs)|Drug: lopinavir/ritonavir (LPV/r) (tablet or capsule) with nucleoside reverse transcriptase inhibitors (NRTIs)|Drug: lopinavir/ritonavir (LPV/r) (tablet or capsule) with nucleoside reverse transcriptase inhibitors (NRTIs) Abbott Phase 3 2005-11-01 2012-02-03
    NCT00175877 Rheumatoid Arthritis Biological: Certolizumab Pegol UCB Pharma Phase 3 2005-06-01 2013-03-22
    NCT01754480 Parenchymous Tissue Surgical Bleeding Biological: Fibrin Sealant Grifols|Device: Surgicel Instituto Grifols, S.A.|Grifols Biologicals Inc. Phase 3 2013-03-01 2016-12-16
    NCT01571960 HIV Infections Biological: GEO-D03 DNA vaccine|Biological: MVA/HIV62B (MVA62B) vaccine|Biological: Placebo for GEO-D03 DNA|Biological: Placebo for MVA62B: National Institute of Allergy and Infectious Diseases (NIAID)|GeoVax, Inc. Phase 1 2012-04-01 2017-01-23
    NCT01509781 in Situ Breast Cancer|Invasive Breast Cancer Procedure: Insertion of suction drain(s) following mastectomy|Procedure: Adaptive skin sutures. National Institute of Oncology, Hungary Phase 3 2011-09-01 2015-10-05
    NCT00596752 Peripheral Arterial Occlusive Disease Drug: Alprostadil|Other: Placebo UCB BIOSCIENCES GmbH|Aptiv Solutions|UCB Pharma Phase 4 2004-03-01 2015-02-26
    NCT01964989 Influenza Virus Biological: Adjuvanted Quadrivalent Subunit Influenza Virus Vaccine (aQIV)|Biological: Non-adjuvanted Trivalent Influenza Vaccine (TIV) / Quadrivalent Influenza Vaccine (QIV) Seqirus|Novartis Vaccines Phase 3 2013-11-01 2016-10-14
    NCT02477839 Epilepsy With Partial-onset Seizures Drug: Lacosamide|Other: Placebo UCB BIOSCIENCES, Inc.|UCB Pharma Phase 3 2015-06-01 2017-02-02
    NCT02326272 Psoriasis|Plaque Psoriasis Biological: Certolizumab Pegol|Other: Placebo UCB Biopharma S.P.R.L.|Dermira, Inc.|UCB Pharma Phase 3 2014-12-01 2017-03-09
    NCT01521923 Rheumatoid Arthritis Biological: Certolizumab Pegol + Methotrexate (MTX)|Biological: Placebo + Methotrexate (MTX) UCB Pharma Phase 3 2012-01-01 2016-11-10
    NCT01519791 Rheumatoid Arthritis Biological: Certolizumab Pegol|Other: Placebo|Biological: Methotrexate UCB Pharma SA|UCB Pharma Phase 3 2012-01-01 2016-01-20
    NCT02743221 Metastatic Colorectal Cancer Drug: Trifluridine/tipiracil hydrochloride (S 95005)|Drug: Capecitabine|Drug: Bevacizumab|Drug: Bevacizumab Institut de Recherches Internationales Servier|Servier Phase 2 2016-04-01 2017-03-16

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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