N6-methyldeoxyadenosine (6mA or m6A) is a DNA modification preserved in prokaryotes to eukaryotes.
N6-methyldeoxyadenosine marks active transcription start sites in Chlamydomonas.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
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[2] J L Boyer et. Al. Competitive and selective antagonism of P2Y1 receptors by N6-methyl 2'-deoxyadenosine 3',5'-bisphosphate. British Journal of Pharmacology, 124(1), 1-3 (1998).
[3] J J Solomon et. Al. In vitro alkylation of calf thymus DNA by acrylonitrile. Isolation of cyanoethyl-adducts of guanine and thymine and carboxyethyl-adducts of adenine and cytosine. Chemico-Biological Interactions, 51(2), 167-190 (1984).
[4] Takuya Yokoyama et. Al. GABA-mediated modulation of ATP-induced intracellular calcium responses in nodose ganglion neurons of the rat. Neuroscience Letters, 584, 168-172 (2015).
分子式 C11H15N5O3 |
分子量 265.27 |
CAS号 2002-35-9 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO <1 mg/mL |
Water Miscible in water. |
Ethanol <1 mg/mL |
体内溶解度
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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