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P1 41

SZL P1-41

P1 41 was a Skp2 inhibitor and was thought to prevent assembly of Skp2-Skp1 complexes.

目录号
EY2023
EY2023
EY2023
EY2023
纯度
99.17%
99.17%
99.17%
99.17%
规格
5 mg
10 mg
25 mg
50 mg
原价
715
1085
2060
3400
售价
715
1085
2060
3400
库存
现货
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Selectively suppresses Skp2 SCF E3 ligase activity but exhibits no effect on the activity of other SCF complexes. Also inhibits Skp2-mediated p27 and Akt ubiquitination in vivo and in vitro. Suppresses the survival of cancer cells and cancer stem cells by triggering cell senescence and inhibiting glycolysis. Exhibits antitumor effects in multiple animal models and cancer cell lines.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Chan et al (2013) Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression. Cell 154 556. PMID:23911321 .

    分子式
    C24H24N2O3S
    分子量
    420.52
    CAS号
    222716-34-9
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    5 mM warmed
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00866307 B-cell Adult Acute Lymphoblastic Leukemia|B-cell Childhood Acute Lymphoblastic Leukemia|Untreated Adult Acute Lymphoblastic Leukemia|Untreated Childhood Acute Lymphoblastic Leukemia Drug: pegaspargase|Drug: cytarabine|Drug: vincristine sulfate|Drug: doxorubicin hydrochloride|Drug: cyclophosphamide|Drug: prednisone|Drug: dexamethasone|Drug: methotrexate|Drug: daunorubicin hydrochloride|Drug: mercaptopurine|Drug: thioguanine|Radiation: prophylactic cranial irradiation|Other: laboratory biomarker analysis Children's Oncology Group|National Cancer Institute (NCI) 2009-02-01 2017-02-07
    NCT02237664 Video-assisted Thoracoscopic Surgery Procedure: Continuous paravertebral analgesia (C-PVB)|Procedure: Patient-controlled paravertebral analgesia (PC-PVB) Dammam University Phase 1|Phase 2 2015-01-01 2015-04-03
    NCT02612103 Inflammatory Bowel Disease|Colitis, Ulcerative|Crohn Disease Line Elberg Godskesen|University of Southern Denmark|Odense University Hospital 2015-11-01 2016-10-11
    NCT03086707 Smokers|Never Smokers Other: Cigarette Philip Morris Products S.A. 2017-01-21 2017-03-21
    NCT03020667 Smoking|Tobacco Product Philip Morris Products S.A. 2016-04-01 2017-01-11
    NCT01055314 Adult Rhabdomyosarcoma|Childhood Alveolar Rhabdomyosarcoma|Childhood Embryonal Rhabdomyosarcoma|Metastatic Childhood Soft Tissue Sarcoma|Stage IV Adult Soft Tissue Sarcoma|Untreated Childhood Rhabdomyosarcoma Biological: Cixutumumab|Drug: Cyclophosphamide|Biological: Dactinomycin|Drug: Doxorubicin Hydrochloride|Drug: Etoposide|Drug: Ifosfamide|Drug: Irinotecan Hydrochloride|Other: Laboratory Biomarker Analysis|Drug: Temozolomide|Drug: Vincristine Sulfate Liposome National Cancer Institute (NCI) Phase 2 2010-01-01 2015-05-22
    NCT01197300 Osteoporosis Drug: zoledronic acid Novartis Pharmaceuticals|Novartis Phase 3 2010-10-01 2016-06-10
    NCT00404820 Osteoporosis Drug: Zoledronic acid 5 mg solution|Drug: Alendronate 70 mg tablets|Drug: Calcium/Vitamin D Novartis Phase 3 2006-10-01 2011-06-06
    NCT02445365 Colitis, Ulcerative|Gastrointestinal Diseases|Pathologic Processes|Intestinal Diseases|Inflammatory Bowel Diseases Device: AutoRIC device Odense University Hospital|University of Southern Denmark|Aarhus University Hospital 2015-05-01 2016-10-11
    NCT02681315 Prematurity, Mechanical Ventilation Device: HHHFNC 6 liter minute|Device: HHHFNC 3 liters/min Mansoura University Children Hospital Phase 3 2016-03-01 2016-09-16
    NCT02510911 Postoperative Ileus|Laparoscopic Colectomy Without Stoma Formation|Colorectal Neoplasm|Diverticulitis Drug: Caffeine (100 mg)|Drug: Caffeine (200 mg)|Drug: corn starch (250 mg approx.)|Other: Radiopaque marker Thomas Steffen|Gottfried und Julia Bangerter-Rhyner Foundation, Switzerland|Cantonal Hospital of St. Gallen 2015-08-01 2016-04-06

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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