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LCS 1

Lung Cancer Screen 1,LCS-1,LCS1

LCS 1 is an inhibitor of SOD1 (superoxide dismutase 1), an enzyme that catalyzes the conversion of superoxide ion (O2-) into H2O2 and O2 to maintain low levels of reactive oxygen species. IC50 of SOD1 = 1.07 µM。

目录号
EY2013
EY2013
EY2013
纯度
98%
98%
98%
规格
5 mg
10 mg
25 mg
原价
492
890
1800
售价
492
890
1800
库存
现货
现货
现货
订购
订购
订购
订购
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  • 生物活性

    LCS 1 is an inhibitor of SOD1 (superoxide dismutase 1), an enzyme that catalyzes the conversion of superoxide ion (O2-) into H2O2 and O2 to maintain low levels of reactive oxygen species. LCS 1 has been shown to inhibit the proliferation of lung adenocarcinoma cell lines. SOD1: IC50 = 0.19 µM (KRAS mutated H358 cell lines); Growth of a variety of human lung adenocarinoma cell lines with EGFR and KRAS mutations: IC50 = 0.2 µM; BJ: EC5050 = 0.56 µM (human); Activity of Superoxide dismutase 1: IC50 = 1.07 µM

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] R. Somwar et al. Superoxide dismutase 1 (SOD1) is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell lines. PNAS 2011, 108, 16375-16380.
    [2] Young-Ok Son et. Al. Nrf2/p62 signaling in apoptosis resistance and its role in cadmium-induced carcinogenesis. Journal of Biological Chemistry, 289(41), 28660-28675 (2014).

    分子式
    C11H8Cl2N2O    		 分子量
    255.1    		 CAS号
    41931-13-9    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    50 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01995708 Multiple Myeloma Biological: CT7, MAGE-A3, and WT1 mRNA-electroporated Langerhans cells ( LCs)|Other: Standard of care Memorial Sloan Kettering Cancer Center|Rockefeller University Phase 1 2014-01-31 2017-02-15
    NCT01434160 Contraception Drug: Skyla (Levonorgestrel, BAY86-5028) Bayer Phase 3 2011-09-01 2015-07-24
    NCT02199015 Cerebral Palsy|Spasticity Device: Lateral spinal cord surgical implant of electrodes Juan Carlos M. Andreani|Fundaci贸n CENIT|Sociedad Argenttina de Neuromodulaci贸n Phase 2|Phase 3 2017-05-01 2017-02-09
    NCT00884260 Contraception Drug: Levonorgestrel IUS (LCS, BAY86-5028) Bayer Phase 3 2009-04-01 2014-08-20
    NCT01030848 Osteoarthritis|Total Knee Replacement Device: Total Knee Replacement (LCS rotating platform) Martina Hansen's Hospital 2003-02-01 2009-12-14
    NCT01397097 Contraception Drug: LNG-IUS (BAY 86-5028)|Drug: 68 mg etonorgestrel implant for subdermal use (Nexplanon) Bayer Phase 3 2011-09-01 2016-07-22
    NCT02366052 Non-alcoholic Fatty Liver Disease|Fatty Liver, Nonalcoholic Behavioral: Nutritional Counseling|Dietary Supplement: Lactobacillus casei shirota (LCS)|Other: Nutritional Counseling and LCS Johannes Gutenberg University Mainz|University of Jena Phase 2 2015-01-01 2017-01-10
    NCT02297880 Eating Behavior Other: Beverage containing low calorie sweeteners|Other: Still water The Coca-Cola Company|CreaBIO 2014-10-01 2017-02-08
    NCT01947868 Non-Small-Cell Lung Cancer AstraZeneca 2013-11-01 2016-09-22
    NCT02652923 Breast Cancer Drug: Sonazoid; Perflubutane for Injection Thomas Jefferson University|National Cancer Institute (NCI)|GE Healthcare|Siemens Medical Solutions Phase 1|Phase 2 2016-01-01 2016-10-17
    NCT01456104 Melanoma Biological: Langerhans-type dendritic cells (a.k.a. Langerhans cells or LCs) Memorial Sloan Kettering Cancer Center|Rockefeller University Phase 1 2011-10-01 2017-01-09
    NCT01123252 Seasonal Affective Rhinitis|Asthma|Grass Allergy Dietary Supplement: Lactobacillus casei Shirota (LcS)|Dietary Supplement: Placebo University of East Anglia|Institute of Food Research|Norfolk and Norwich University Hospitals NHS Foundation Trust|Yakult Honsha Co., LTD Phase 2 2010-09-01 2012-08-22
    NCT00822328 Signs and Symptoms, Digestive Dietary Supplement: Yakult300|Dietary Supplement: Lactobacillus casei strain Shirota Cheng Hsin Rehabilitation Medical Center Phase 2 2009-01-01 2009-08-27
    NCT00526786 Barrett's Esophagus|High Grade Dysplasia|Low Grade Dysplasia Device: CryoSpray Ablation System (510(k) NO: K070893) CSA Medical, Inc. Phase 4 2007-09-01 2014-03-12
    NCT03074045 Contraception Drug: Levonorgestrel (Kyleena, BAY86-5028)|Drug: Ethinyl estradiol and drospirenone (Yarina, BAY86-5131) Bayer Phase 3 2017-03-01 2017-03-03
    NCT02618005 Immune Function and Intestinal Microbiota Dietary Supplement: Probiotic capsule Yakult Honsha Co., LTD|Japan Aerospace Exploration Agency 2015-10-01 2016-07-21
    NCT01595022 Contraception Drug: Placebo: Flexi ring FR01|Drug: Placebo: Flexi ring FR20|Drug: Placebo: Ultra low dose levonorgestrel contraceptive system (LCS) Bayer Phase 1 2010-01-01 2015-04-02
    NCT00528112 Contraception Drug: LCS12|Drug: LCS16 Bayer Phase 3 2007-08-01 2016-12-01
    NCT01017120 Acne Vulgaris Drug: Tazarotene Foam|Drug: Vehicle Foam Stiefel, a GSK Company|GlaxoSmithKline Phase 3 2009-10-01 2016-11-30
    NCT01017146 Acne Vulgaris Drug: Tazarotene foam|Drug: Vehicle Foam Stiefel, a GSK Company|GlaxoSmithKline Phase 3 2009-10-01 2016-11-30
    NCT00097214 Non-small Cell Lung Cancer Drug: Carboplatin|Biological: Cetuximab ImClone LLC|Bristol-Myers Squibb Phase 2 2004-11-01 2010-04-08

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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