Home > others & > Cefoperazone

Cefoperazone

头孢哌酮

Cefoperazone (头孢哌酮) 是头孢菌素类抗生素。

目录号
EY1845
EY1845
EY1845
纯度
99.63%
99.63%
99.63%
规格
500 mg
1 g
5 g
原价
245
398
1110
售价
245
398
1110
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Cefoperazone is an antimicrobial agent that possesses potent LACTB (β-lactamase) inhibitory properties.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

    20 mg/kg静脉注射

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Kato Y, et al. Drug Metab Dispos, 2008, 36(6), 1088-1096.
    [2] Fawaz Alasmari,et al. Effects of cefazolin and cefoperazone on glutamate transporter 1 isoforms and cystine/glutamate exchanger as well as alcohol drinking behavior in male alcohol-preferring rats. Brain Res. Author manuscript; available in PMC 2017 Mar 1. Published in final edited form as: Brain Res. 2016 Mar 1; 1634: 150–157. Published online 2016 Jan 11. doi: 10.1016/j.brainres.2016.01.007.
    [3] Casey M. Theriot,et al. Cefoperazone-treated mice as an experimental platform to assess differential virulence of Clostridium difficile strains. Gut Microbes. 2011 Nov 1; 2(6): 326–334. doi: 10.4161/gmic.19142.

    分子式
    C25H27N9O8S2
    分子量
    645.67
    CAS号
    62893-19-0
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    100 mg/mL
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02352025 Breast Cancer Drug: S-equol The University of Texas Health Science Center at San Antonio Early Phase 1 2015-04-01 2016-08-04
    NCT02142777 Alzheimer's Disease Drug: S -Equol|Drug: Placebo Russell Swerdlow, MD|Ausio Pharmaceuticals, LLC|University of Kansas Medical Center Phase 1 2014-07-01 2016-08-12
    NCT00962390 Benign Prostatic Hyperplasia Drug: S-equol|Drug: Placebo Ausio Pharmaceuticals, LLC Phase 2 2009-06-01 2016-01-08
    NCT00962585 Menopause Drug: Placebo|Drug: S-equol Ausio Pharmaceuticals, LLC Phase 2 2010-06-01 2014-03-11
    NCT00787007 Healthy Drug: S-equol|Drug: Placebo Ausio Pharmaceuticals, LLC Phase 1 2008-09-01 2012-01-19
    NCT02515682 Hypertension Dietary Supplement: High equol group|Dietary Supplement: Low equol group|Dietary Supplement: Placebo Chinese University of Hong Kong 2015-10-01 2015-08-03
    NCT00998920 Healthy Drug: S-equol|Drug: Placebo Ausio Pharmaceuticals, LLC Phase 1 2008-12-01 2012-07-11
    NCT01301586 ACNE VULGARIS Drug: Doxycycline and S-equol|Drug: Doxycycline Nexgen Dermatologics, Inc. Phase 1|Phase 2 2010-11-01 2011-02-18
    NCT01173380 Metabolic Syndrome X Other: Soy nuts|Other: Matched food University of California, Davis 2010-08-01 2015-09-02
    NCT00924339 Familial Hypercholesterolemia Dietary Supplement: soy protein diet|Dietary Supplement: rapeseed oil Medical University of Vienna 2009-09-01 2009-06-17
    NCT01270737 Hypertension Dietary Supplement: Whole soy (soy flour)|Dietary Supplement: daidzein|Dietary Supplement: milk powder Chinese University of Hong Kong 2011-03-01 2011-01-04
    NCT01232751 Postmenopause Dietary Supplement: Isoflavone supplement Wageningen University 2010-08-01 2012-01-09
    NCT00366860 Osteoporosis|Cardiovascular Diseases Behavioral: Soy bread University of Michigan|Ohio State University Phase 1 2004-01-01 2014-12-01
    NCT00244907 Osteoporosis|Osteopenia Dietary Supplement: Genistein vs Risedronate Purdue University|National Center for Complementary and Integrative Health (NCCIH)|Office of Dietary Supplements (ODS) Phase 1 2006-01-01 2014-02-07
    NCT01116310 Postmenopausal Women With Moderate Vasomotor Symptoms Drug: Soy isoflavones (Glycine max L) and red clover extract (Trifolium pretense L)|Drug: Placebo Laboratorios Casen-Fleet S.L.U.|Apices Soluciones S.L.|Asociacion Colaboracion Cochrane Iberoamericana Phase 4 2010-04-01 2011-09-27
    NCT00765479 Prostate Cancer Dietary Supplement: soy protein isolate|Other: placebo University of Illinois at Chicago|National Cancer Institute (NCI) Phase 2|Phase 3 2006-12-01 2013-09-19

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

  • 相关化合物库

  • 使用AMQUAR产品发表文献后请联系我们

相关推荐

X
  • 联系人 :
  • 收件地址 :
  • 电话号码 :
  • 单位名称 :
  • 产品货号 :
  • 产品规格 :
  • 发票抬头以及单位税号 :