Equol

雌马酚

Equol是是大豆的代谢物,是人类的一种重要的异黄酮,与5α-DHT特异性结合,对重组雌激素受体ERβ具有适度的亲和力。

目录号
EY1841
EY1841
EY1841
EY1841
EY1841
纯度
99.34%
99.34%
99.34%
99.34%
99.34%
规格
5 mg
10 mg
25 mg
50 mg
100 mg
原价
480
682
1120
1990
3600
售价
480
682
1120
1990
3600
库存
现货
现货
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Equol ,a metabolite of soybeans, is an important isoflavone in humans,specifically binds to 5α-DHT, has a modest affinity for recombinant estrogen receptor ERβ. Phase 2.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

    0 μM-10 μM

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Muthyala RS, et al. Bioorg Med Chem, 2004, 12(6), 1559-1567.
    [2] Columba de la Parra,et al. Equol, an Isoflavone Metabolite, Regulates Cancer Cell Viability and Protein Synthesis Initiation via c-Myc and eIF4G. J Biol Chem. 2015 Mar 6; 290(10): 6047–6057. Published online 2015 Jan 15. doi: 10.1074/jbc.M114.617415.
    [3] Zhi-Ping Yang,et al. Equol inhibits proliferation of human gastric carcinoma cells via modulating Akt pathway. World J Gastroenterol. 2015 Sep 28; 21(36): 10385–10399. Published online 2015 Sep 28. doi: 10.3748/wjg.v21.i36.10385.

    分子式
    C15H14O3
    分子量
    242.27
    CAS号
    531-95-3
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    48 mg/mL
    Water
    <1 mg/mL
    Ethanol
    48 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02352025 Breast Cancer Drug: S-equol The University of Texas Health Science Center at San Antonio Early Phase 1 2015-04-01 2016-08-04
    NCT02142777 Alzheimer's Disease Drug: S -Equol|Drug: Placebo Russell Swerdlow, MD|Ausio Pharmaceuticals, LLC|University of Kansas Medical Center Phase 1 2014-07-01 2016-08-12
    NCT00962390 Benign Prostatic Hyperplasia Drug: S-equol|Drug: Placebo Ausio Pharmaceuticals, LLC Phase 2 2009-06-01 2016-01-08
    NCT00962585 Menopause Drug: Placebo|Drug: S-equol Ausio Pharmaceuticals, LLC Phase 2 2010-06-01 2014-03-11
    NCT00787007 Healthy Drug: S-equol|Drug: Placebo Ausio Pharmaceuticals, LLC Phase 1 2008-09-01 2012-01-19
    NCT02515682 Hypertension Dietary Supplement: High equol group|Dietary Supplement: Low equol group|Dietary Supplement: Placebo Chinese University of Hong Kong 2015-10-01 2015-08-03
    NCT00998920 Healthy Drug: S-equol|Drug: Placebo Ausio Pharmaceuticals, LLC Phase 1 2008-12-01 2012-07-11
    NCT01301586 ACNE VULGARIS Drug: Doxycycline and S-equol|Drug: Doxycycline Nexgen Dermatologics, Inc. Phase 1|Phase 2 2010-11-01 2011-02-18
    NCT01173380 Metabolic Syndrome X Other: Soy nuts|Other: Matched food University of California, Davis 2010-08-01 2015-09-02
    NCT00924339 Familial Hypercholesterolemia Dietary Supplement: soy protein diet|Dietary Supplement: rapeseed oil Medical University of Vienna 2009-09-01 2009-06-17
    NCT01270737 Hypertension Dietary Supplement: Whole soy (soy flour)|Dietary Supplement: daidzein|Dietary Supplement: milk powder Chinese University of Hong Kong 2011-03-01 2011-01-04
    NCT01232751 Postmenopause Dietary Supplement: Isoflavone supplement Wageningen University 2010-08-01 2012-01-09
    NCT00366860 Osteoporosis|Cardiovascular Diseases Behavioral: Soy bread University of Michigan|Ohio State University Phase 1 2004-01-01 2014-12-01
    NCT00244907 Osteoporosis|Osteopenia Dietary Supplement: Genistein vs Risedronate Purdue University|National Center for Complementary and Integrative Health (NCCIH)|Office of Dietary Supplements (ODS) Phase 1 2006-01-01 2014-02-07
    NCT01116310 Postmenopausal Women With Moderate Vasomotor Symptoms Drug: Soy isoflavones (Glycine max L) and red clover extract (Trifolium pretense L)|Drug: Placebo Laboratorios Casen-Fleet S.L.U.|Apices Soluciones S.L.|Asociacion Colaboracion Cochrane Iberoamericana Phase 4 2010-04-01 2011-09-27
    NCT00765479 Prostate Cancer Dietary Supplement: soy protein isolate|Other: placebo University of Illinois at Chicago|National Cancer Institute (NCI) Phase 2|Phase 3 2006-12-01 2013-09-19

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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