Equol是是大豆的代谢物,是人类的一种重要的异黄酮,与5α-DHT特异性结合,对重组雌激素受体ERβ具有适度的亲和力。
Equol ,a metabolite of soybeans, is an important isoflavone in humans,specifically binds to 5α-DHT, has a modest affinity for recombinant estrogen receptor ERβ. Phase 2.
0 μM-10 μM
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Muthyala RS, et al. Bioorg Med Chem, 2004, 12(6), 1559-1567.
[2] Columba de la Parra,et al. Equol, an Isoflavone Metabolite, Regulates Cancer Cell Viability and Protein Synthesis Initiation via c-Myc and eIF4G. J Biol Chem. 2015 Mar 6; 290(10): 6047–6057. Published online 2015 Jan 15. doi: 10.1074/jbc.M114.617415.
[3] Zhi-Ping Yang,et al. Equol inhibits proliferation of human gastric carcinoma cells via modulating Akt pathway. World J Gastroenterol. 2015 Sep 28; 21(36): 10385–10399. Published online 2015 Sep 28. doi: 10.3748/wjg.v21.i36.10385.
分子式 C15H14O3 |
分子量 242.27 |
CAS号 531-95-3 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 48 mg/mL |
Water <1 mg/mL |
Ethanol 48 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT02352025 | Breast Cancer | Drug: S-equol | The University of Texas Health Science Center at San Antonio | Early Phase 1 | 2015-04-01 | 2016-08-04 |
NCT02142777 | Alzheimer's Disease | Drug: S -Equol|Drug: Placebo | Russell Swerdlow, MD|Ausio Pharmaceuticals, LLC|University of Kansas Medical Center | Phase 1 | 2014-07-01 | 2016-08-12 |
NCT00962390 | Benign Prostatic Hyperplasia | Drug: S-equol|Drug: Placebo | Ausio Pharmaceuticals, LLC | Phase 2 | 2009-06-01 | 2016-01-08 |
NCT00962585 | Menopause | Drug: Placebo|Drug: S-equol | Ausio Pharmaceuticals, LLC | Phase 2 | 2010-06-01 | 2014-03-11 |
NCT00787007 | Healthy | Drug: S-equol|Drug: Placebo | Ausio Pharmaceuticals, LLC | Phase 1 | 2008-09-01 | 2012-01-19 |
NCT02515682 | Hypertension | Dietary Supplement: High equol group|Dietary Supplement: Low equol group|Dietary Supplement: Placebo | Chinese University of Hong Kong | 2015-10-01 | 2015-08-03 | |
NCT00998920 | Healthy | Drug: S-equol|Drug: Placebo | Ausio Pharmaceuticals, LLC | Phase 1 | 2008-12-01 | 2012-07-11 |
NCT01301586 | ACNE VULGARIS | Drug: Doxycycline and S-equol|Drug: Doxycycline | Nexgen Dermatologics, Inc. | Phase 1|Phase 2 | 2010-11-01 | 2011-02-18 |
NCT01173380 | Metabolic Syndrome X | Other: Soy nuts|Other: Matched food | University of California, Davis | 2010-08-01 | 2015-09-02 | |
NCT00924339 | Familial Hypercholesterolemia | Dietary Supplement: soy protein diet|Dietary Supplement: rapeseed oil | Medical University of Vienna | 2009-09-01 | 2009-06-17 | |
NCT01270737 | Hypertension | Dietary Supplement: Whole soy (soy flour)|Dietary Supplement: daidzein|Dietary Supplement: milk powder | Chinese University of Hong Kong | 2011-03-01 | 2011-01-04 | |
NCT01232751 | Postmenopause | Dietary Supplement: Isoflavone supplement | Wageningen University | 2010-08-01 | 2012-01-09 | |
NCT00366860 | Osteoporosis|Cardiovascular Diseases | Behavioral: Soy bread | University of Michigan|Ohio State University | Phase 1 | 2004-01-01 | 2014-12-01 |
NCT00244907 | Osteoporosis|Osteopenia | Dietary Supplement: Genistein vs Risedronate | Purdue University|National Center for Complementary and Integrative Health (NCCIH)|Office of Dietary Supplements (ODS) | Phase 1 | 2006-01-01 | 2014-02-07 |
NCT01116310 | Postmenopausal Women With Moderate Vasomotor Symptoms | Drug: Soy isoflavones (Glycine max L) and red clover extract (Trifolium pretense L)|Drug: Placebo | Laboratorios Casen-Fleet S.L.U.|Apices Soluciones S.L.|Asociacion Colaboracion Cochrane Iberoamericana | Phase 4 | 2010-04-01 | 2011-09-27 |
NCT00765479 | Prostate Cancer | Dietary Supplement: soy protein isolate|Other: placebo | University of Illinois at Chicago|National Cancer Institute (NCI) | Phase 2|Phase 3 | 2006-12-01 | 2013-09-19 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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