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Cinacalcet HCl

盐酸西那卡塞,盐酸甲状旁腺激素,AMG-073 HCl,AMG073 HCl,AMG 073 HCl,

Cinacalcet hydrochloride是口服活性的第二代拟钙剂，对甲状旁腺机能亢进有效。

目录号
EY1810
EY1810
EY1810
EY1810
纯度
99.55%
99.55%
99.55%
99.55%
规格
5 mg
10 mg
50 mg
100 mg
原价
320
520
980
1700
售价
320
520
980
1700
库存
现货
现货
现货
现货
订购
订购
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  • 生物活性

    Cinacalcet HCl represents a new class of compounds for the treatment of hyperparathyroidism.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Ure?a P, et al. Kidney Int Suppl, 2003, (85), S91-96.

    分子式
    C22H23ClF3N    		 分子量
    393.87    		 CAS号
    364782-34-3    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    79 mg/mL    		 Water
    1 mg/mL    		 Ethanol
    33 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01479088 Secondary Hyperparathyroidism Drug: Cinacalcet HCl ENRICO VERRINA|Istituto Giannina Gaslini Phase 2|Phase 3 2010-03-01 2011-11-23
    NCT00094484 Kidney Disease|Chronic Kidney Disease Drug: Cinacalcet HCl Amgen Phase 3 2004-10-01 2013-05-06
    NCT01439867 Chronic Kidney Disease|Hyperparathyroidism, Secondary Drug: Cinacalcet HCl Amgen Phase 2 2012-06-01 2016-11-11
    NCT01290029 Chronic Kidney Disease|Hyperparathyroidism, Secondary|Secondary Hyperparathyroidism Drug: Cinacalcet Amgen Phase 1 2011-01-01 2016-10-26
    NCT02341417 Secondary Hyperparathyroidism, Chronic Kidney Disease Drug: Cinacalcet Amgen Phase 3 2015-06-10 2017-03-21
    NCT02138838 Chronic Kidney Disease, Secondary Hyperparathyroidism Drug: Cinacalcet HCl|Dietary Supplement: Standard of Care Amgen Phase 3 2014-11-01 2016-11-14
    NCT00431496 Anemia|Secondary Hyperparathyroidism Drug: Cinacalcet Amgen Phase 4 2006-09-01 2013-04-18
    NCT00952094 Healthy Drug: KRN1493 Seoul National University Hospital|Jeil-Kirin Pharmaceutical Inc.|Kyowa Hakko Kirin Pharma, Inc. Phase 1 2008-11-01 2009-08-03
    NCT01460030 Parathyroid Carcinoma|Hypercalcemia|Primary Hyperparathyroidism Drug: Cinacalcet HCl Kyowa Hakko Kirin Co., Ltd Phase 3 2011-11-01 2017-02-28
    NCT01143987 Hyperparathyroidism|Arterial Stiffness Drug: Cinacalcet Chinese University of Hong Kong Phase 4 2010-06-01 2013-11-11
    NCT01896232 Secondary Hyperparathyroidism|Chronic Kidney Disease Drug: Etelcalcetide|Drug: Cinacalcet|Drug: Oral Placebo|Drug: Intravenous Placebo Amgen Phase 3 2013-08-01 2017-02-07
    NCT02417389 Hyperparathyroidism, Primary|Osteoporosis Drug: cinacalcet|Drug: Alendronate Istituto Auxologico Italiano Phase 4 2008-05-01 2015-04-11
    NCT00527267 Hyperparathyroidism Drug: Placebo|Drug: AMG 073 Amgen Phase 3 2002-02-01 2009-01-22
    NCT00844740 Familial Hypophosphatemic Rickets Drug: Cinacalcet Children's Mercy Hospital Kansas City 2009-02-01 2009-02-13
    NCT01277510 Chronic Kidney Disease|Hyperparathyroidism|Hyperparathyroidism, Secondary|Kidney Disease|Secondary Hyperparathyroidism Drug: cinacalcet capsule|Drug: placebo|Drug: Standard of Care Amgen Phase 3 2011-06-01 2015-06-12
    NCT00261950 Secondary Hyperparathyroidism Drug: Sensipar (Cinacalcet HCl) Amgen Phase 2 2006-05-01 2014-06-24
    NCT01011114 Hypophosphatemia|Renal Transplant Drug: Cinacalcet|Drug: Placebo Montefiore Medical Center 2009-11-01 2012-10-22
    NCT00975221 Hyperparathyroidism, Primary|Hypercalcemia Drug: Cinacalcet|Drug: Placebo Amgen Phase 3 2010-03-01 2016-02-02
    NCT00936988 Hyperparathyroidism, Primary Drug: cinacalcet Amgen Phase 2 2000-11-01 2013-05-06
    NCT00379899 Chronic Kidney Disease|End Stage Renal Disease|Coronary Artery Calcification|Vascular Calcification|Calcification|Cardiovascular Disease|Chronic Renal Failure|Hyperparathyroidism|Kidney Disease|Nephrology|Secondary Hyperparathyroidism Drug: cinacalcet Amgen Phase 4 2006-09-01 2014-07-14

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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