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Ospemifene

欧司哌米

Ospemifene is a non-hormonal selective estrogen receptor modulator (SERM) which is used for the treatment of dyspareunia.

目录号
EY1797
EY1797
EY1797
EY1797
EY1797
纯度
99.32%
99.32%
99.32%
99.32%
99.32%
规格
5 mg
10 mg
50 mg
100 mg
200 mg
原价
302
490
835
990
1400
售价
302
490
835
990
1400
库存
现货
现货
现货
现货
现货
订购
订购
订购
订购
订购
订购
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  • 生物活性

    Ospemifene is a non-hormonal selective estrogen receptor modulator (SERM), used for the treatment of dyspareunia.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Miia Turpeinen,et al. Effects of Ospemifene on Drug Metabolism Mediated by Cytochrome P450 Enzymes in Humans in Vitro and in Vivo. Int J Mol Sci. 2013 Jul; 14(7): 14064–14075. Published online 2013 Jul 5. doi: 10.3390/ijms140714064.
    [2] S. R. Goldstein,et al. Ospemifene and 4-Hydroxyospemifene Effectively Prevent and Treat Breast Cancer in the MTag.Tg Transgenic Mouse Model. Climacteric. 2014 Apr; 17(2): 173–182. Published online 2013 Nov 23. doi: 10.3109/13697137.2013.834493.

    分子式
    C24H23ClO2    		 分子量
    378.89    		 CAS号
    128607-22-7    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    75 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    70 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT03018106 Sexual Dysfunction, Physiological Drug: Ospemifene|Drug: Vaginal conjugated estrogens Emory University Phase 4 2017-01-01 2017-03-16
    NCT02784613 Vulvovaginal Atrophy|Dyspareunia Drug: Ospemifene Sue Goldstein|San Diego Sexual Medicine Phase 4 2015-07-01 2016-09-29
    NCT02638337 Vaginal Dryness Drug: Ospemifene|Drug: Placebo Shionogi|Shionogi Inc. Phase 3 2015-12-01 2017-03-23
    NCT00566982 Atrophy|Vaginal Diseases Drug: Ospemifene 60 mg|Drug: Placebo Shionogi|Hormos Medical|QuatRx Pharmaceuticals|Shionogi Inc. Phase 3 2007-10-01 2013-05-21
    NCT02010580 Menopause University of Oklahoma 2014-01-01 2014-12-02
    NCT00729469 Atrophy|Vaginal Diseases Drug: Ospemifene 60 mg|Drug: Placebo|Drug: Non-hormonal vaginal lubricant Shionogi|Hormos Medical|QuatRx Pharmaceuticals|Shionogi Inc. Phase 3 2008-07-01 2013-05-21
    NCT00630539 Atrophy|Vaginal Diseases Drug: Placebo|Drug: Ospemifene 5 mg|Drug: Ospemifene 15 mg|Drug: Ospemifene 30 mg Shionogi|Hormos Medical|QuatRx Pharmaceuticals|Shionogi Inc. Phase 2 2007-08-01 2013-05-21
    NCT00276094 Atrophy|Vaginal Diseases Drug: Ospemifene 30 mg|Drug: Ospemifene 60 mg|Drug: Placebo|Drug: Nonhormonal vaginal lubricant Shionogi|Hormos Medical|QuatRx Pharmaceuticals|Shionogi Inc. Phase 3 2006-01-01 2013-05-21
    NCT01586364 Atrophy|Vaginal Diseases Drug: Ospemifene Shionogi|QuatRx Pharmaceuticals|Shionogi Inc. Phase 3 2006-05-01 2013-05-21
    NCT01585558 Atrophy|Vaginal Diseases Drug: Ospemifene (Dose 1)|Drug: Ospemifene (Dose 2)|Drug: Placebo Shionogi|QuatRx Pharmaceuticals|Shionogi Inc. Phase 3 2006-05-01 2013-05-21

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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