Desvenlafaxine

去甲文拉法辛,WY45233 Succinate,WY-45233 Succinate,WY 45233 Succinate

Desvenlafaxine是5-羟色胺(5-HT)和去甲肾上腺素(NE)重吸收抑制剂,Ki为40.2 nM和558.4 nM。

目录号
EY1795
EY1795
纯度
99.67%
99.67%
规格
100 mg
500 mg
原价
480
690
售价
480
690
库存
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Desvenlafaxine is a serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor with Ki of 40.2 nM and 558.4 nM, respectively.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

    30mg/kg 口服

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Deecher DC, et al. J Pharmacol Exp Ther, 2006, 318(2), 657-665.

    分子式
    C16H25NO2
    分子量
    263.38
    CAS号
    93413-62-8
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    36 mg/mL
    Water
    <1 mg/mL
    Ethanol
    5 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02200406 Depression|Opioid Dependence|Methadone Treatment Drug: Desvenlafaxine Didier Jutras-Aswad|Pfizer|Centre hospitalier de l'Universit de Montral (CHUM) Phase 4 2014-07-01 2016-09-01
    NCT00888862 Major Depressive Disorder|Menopausal Staging and Vasomotor Symptoms (for Females) Drug: Desvenlafaxine Succinate Hamilton Health Sciences Corporation|Wyeth is now a wholly owned subsidiary of Pfizer|St. Joseph's Healthcare Hamilton|McMaster University Phase 3 2009-06-01 2012-02-07
    NCT01948895 Dysthymic Disorder Drug: Desvenlafaxine Centre for Addiction and Mental Health 2012-08-01 2014-11-06
    NCT01974934 Vascular Depression Drug: Desvenlafaxine Succinate Hotel-Dieu Grace Healthcare Phase 4 2013-12-01 2015-03-18
    NCT02819921 Hot Flashes|Breast Neoplasms Drug: Desvenlafaxine succinate|Drug: Placebo Seoul National University Hospital|Seoul National University Bundang Hospital|Korea Cancer Center Hospital|Pfizer Phase 4 2016-09-01 2016-06-28
    NCT00818155 Healthy Drug: desvenlafaxine succinate SR|Other: Placebo Wyeth is now a wholly owned subsidiary of Pfizer Phase 1 2009-01-01 2013-01-28
    NCT01537068 Dysthymic Disorder|Dysthymia|Chronic Depressive Disorder Drug: Desvenlafaxine|Drug: Placebo New York State Psychiatric Institute|Pfizer Phase 4 2012-02-01 2015-04-13
    NCT01188668 Pharmacokinetics|Cytochrome P-450 CYP2D6|CYP3A4 Protein, Human Drug: Aripiprazole|Drug: Aripiprazole + desvenlafaxine succinate sustained release Pfizer Phase 4 2010-08-01 2011-11-01
    NCT02859103 Depression|Anhedonia Drug: Desvenlafaxine St. Michael's Hospital, Toronto Phase 4 2016-11-01 2016-08-03
    NCT01316302 Social Anxiety Disorder Drug: Pristiq|Drug: Placebo The Medical Research Network|Pfizer Phase 4 2011-04-01 2016-08-23
    NCT01353963 Major Depressive Disorder|Vasomotor Symptoms Drug: desvenlafaxine succinate Pfizer Phase 4 2012-03-01 2015-12-04
    NCT01527786 Depression Drug: Desvenlafaxine BC Women's Hospital & Health Centre Phase 3 2010-11-01 2015-01-26
    NCT01432457 Major Depressive Disorder Drug: desvenlafaxine succinate sustained-release 50 mg/day|Drug: desvenlafaxine succinate sustained-release 100 mg/day|Drug: placebo Pfizer Phase 4 2011-10-01 2013-12-17
    NCT00831415 Major Depressive Disorder Drug: desvenlafaxine succinate sustained release tablets Pfizer Phase 3 2009-03-01 2011-12-22
    NCT02988024 Major Depression Drug: LY03005|Drug: Pristiq Luye Pharma Group Ltd. Phase 1 2016-12-07 2017-03-17
    NCT01189500 Pharmacokinetics Drug: Tamoxifen|Drug: Tamoxifen and Desvenlafaxine Succinate Sustained Release Pfizer Phase 4 2010-08-01 2011-11-01
    NCT00824291 Depressive Disorder, Major Drug: desvenlafaxine succinate sustained release|Genetic: Genotyping Wyeth is now a wholly owned subsidiary of Pfizer Phase 3 2009-02-01 2011-03-04
    NCT01443208 Major Depressive Disorder Drug: desvenlafaxine|Drug: desvenlafaxine|Drug: desvenlafaxine Pfizer Phase 1 2011-11-01 2011-12-29
    NCT01101152 Healthy Drug: Desvenlafaxine succinate University of Ottawa Phase 1 2010-04-01 2011-08-04
    NCT01803711 Major Depression|Cancer|Diabetes|Cardiovascular Diseases Drug: Desvenlafaxine|Dietary Supplement: Omega 3 Fatty acids|Drug: Placebo (for Omega 3 fatty acid supplement) UConn Health Phase 2|Phase 3 2013-02-01 2016-03-03
    NCT01492621 Major Depression Drug: Desvenlafaxine Centre de recherche Fernand-Seguin, H么pital Louis-H. Lafontaine|Pfizer Phase 4 2011-11-01 2011-12-14
    NCT01977378 Major Depressive Disorder Drug: Sustained-Release Desvenlafaxine Hydrochloride|Drug: Sustained-Release Venlafaxine Hydrochloride Jiangsu Hansoh Pharmaceutical Co., Ltd. Phase 2|Phase 3 2013-10-01 2013-10-30
    NCT01121484 Major Depressive Disorder Drug: desvenlafaxine succinate sustained-release|Drug: placebo Pfizer Phase 4 2010-06-01 2012-03-30
    NCT01221935 Major Depressive Disorder Other: Pristiq first-line treatment charts|Other: Pristiq second-line treatment charts|Other: SNRI or SSRI first-line treatment charts|Other: SNRI or SSRI second-line treatment charts Pfizer Phase 4 2009-09-01 2011-01-25
    NCT00887224 Major Depressive Disorder Drug: Desvenlafaxine succinate sustained release 50 mg|Drug: Desvenlafaxine succinate sustained release 25 mg|Drug: Placebo Pfizer Phase 3 2009-06-01 2014-11-06

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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