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Paroxetine HCl

盐酸帕罗西汀,BRL-29060A,BRL 29060A,FG-7051,FG 7051,FG7051,

Paroxetine hydrochloride 是选择性5-羟色胺重吸收抑制剂（SSRI）。

目录号
EY1790
EY1790
纯度
99.15%
99.15%
规格
100 mg
500 mg
原价
590
1120
售价
590
1120
库存
现货
现货
订购
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  • 生物活性

    Paroxetine HCl is an antidepressant drug of the SSRI type.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Le Poul E, et al. Naunyn Schmiedebergs Arch Pharmacol, 1995, 352(2), 141-148.

    分子式
    C19H21ClFNO3    		 分子量
    365.83    		 CAS号
    78246-49-8    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    74 mg/mL    		 Water
    10 mg/mL    		 Ethanol
    35 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00841659 Healthy Drug: Paroxetine HCl|Drug: Paxil Teva Pharmaceuticals USA Phase 1 2002-08-01 2009-09-09
    NCT00841698 Healthy Drug: Paroxetine HCl|Drug: Paxil Teva Pharmaceuticals USA Phase 1 2002-10-01 2009-09-09
    NCT01841502 Hepatitis C Infection|Depression Drug: Paroxetine|Drug: telaprevir Radboud University|Janssen, LP Phase 2 2013-05-01 2014-10-27
    NCT00749359 Depressive Disorder Drug: Paxil CR GlaxoSmithKline Phase 1 2008-07-01 2016-11-04
    NCT01829919 Postmenopausal Symptoms Drug: Brisdelle (paroxetine mesylate) Noven Therapeutics Phase 1 2011-07-01 2015-10-14
    NCT00184106 Phobic Disorders Drug: Seroxat, Cognitive therapy, Seroxat+ cognitive therapy Norwegian University of Science and Technology|St. Olavs Hospital Phase 4 2004-10-01 2017-02-23
    NCT00610610 Fibromyalgia Syndrome Drug: Paroxetine CR|Drug: Placebo Duke University|GlaxoSmithKline Phase 4 2002-01-01 2013-06-19
    NCT01000857 Depressive Disorder Drug: Paroxetine CR and Paroxetine IR GlaxoSmithKline Phase 1 2009-11-01 2017-01-25
    NCT00406003 Pharmacokinetics|Depressive Disorder Drug: Paroxetine controlled Release 12.5mg, 25mg and37.5mg GlaxoSmithKline Phase 1 2006-03-01 2012-05-31
    NCT00812812 Depressive Disorder Drug: paroxetine 10mg tablet|Drug: paroxetine 20mg tablet|Drug: matched placebo to paroxetine 10mg|Drug: matched placebo to paroxetine 20mg GlaxoSmithKline Phase 4 2009-03-01 2016-11-29
    NCT00225914 Menopause Drug: Paroxetine|Drug: placebo Massachusetts General Hospital|GlaxoSmithKline Phase 4 2004-09-01 2010-11-23
    NCT01159821 Healthy Drug: 31001074/paroxetine Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Phase 1 2010-08-01 2014-04-07
    NCT02681198 Healthy Drug: Lofexidine|Drug: Paroxetine US WorldMeds LLC|National Institute on Drug Abuse (NIDA) Phase 1 2016-02-01 2016-10-31
    NCT01361308 Postmenopausal Symptoms Drug: Brisdelle (paroxetine mesylate)|Drug: Placebo capsules Noven Therapeutics Phase 3 2011-05-01 2015-10-14
    NCT01376271 Social Phobia Drug: Paroxetine GlaxoSmithKline 2010-01-01 2014-06-30
    NCT01101841 Hot Flashes Drug: Brisdelle (paroxetine mesylate)|Drug: Placebo capsules Noven Therapeutics Phase 3 2010-03-01 2015-10-14
    NCT00560612 Stress Disorders, Post-Traumatic Drug: Paroxetine|Drug: Placebo Durham VA Medical Center Phase 4 2006-01-01 2011-03-31
    NCT00786188 Hot Flashes Drug: Brisdelle (paroxetine mesylate)|Drug: Sugar pill Noven Therapeutics Phase 2 2008-11-01 2015-10-14
    NCT00620581 Premenstrual Dysphoric Disorder Drug: Paroxetine Hamilton Health Sciences Corporation|McMaster University Phase 3 2008-02-07
    NCT01376128 Panic Disorder Drug: Paroxetine GlaxoSmithKline 2008-03-01 2011-06-16
    NCT00767754 Panic Disorder Drug: Paxil CR Samsung Medical Center Phase 4 2007-01-01 2011-07-21
    NCT00259883 Mental Disorders Drug: paroxetine GlaxoSmithKline Phase 4 2005-06-01 2017-01-16

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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