Isotretinoin

异维甲酸,异维 A 酸,13-cis retinoic acid

Isotretinoin (异维A酸; 13-cis-Retinoic acid) 可作用于重度粉刺,还可用于脑癌,胰腺癌等化疗。

目录号
EY1789
EY1789
纯度
99.55%
99.55%
规格
100 mg
500 mg
原价
392
968
售价
392
968
库存
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    It was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Webster WS, et al. J Craniofac Genet Dev Biol, 1986, 6(3), 211-222.

    分子式
    C20H28O2
    分子量
    300.44
    CAS号
    4759-48-2
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    58 mg/mL
    Water
    <1 mg/mL
    Ethanol
    25 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01319838 Neuroblastoma Drug: Isotretinoin Emory University|Children's Healthcare of Atlanta Phase 1 2011-03-01 2013-12-09
    NCT01888328 Healthy Drug: Isotretinoin Dr. Reddy's Laboratories Limited Phase 1 2001-05-01 2013-06-26
    NCT01888341 Healthy Drug: Isotretinoin Dr. Reddy's Laboratories Limited Phase 1 2002-08-01 2013-06-26
    NCT01888289 Healthy Drug: Isotretinoin Dr. Reddy's Laboratories Limited Phase 1 2001-07-01 2013-06-26
    NCT01888224 Healthy Drug: Isotretinoin Dr. Reddy's Laboratories Limited Phase 1 2011-06-01 2013-06-25
    NCT02457520 Acne Drug: Isotretinoin Ranbaxy Inc. Phase 4 2015-01-01 2015-05-28
    NCT00003564 Brain and Central Nervous System Tumors Drug: Isotretinoin|Drug: Procarbazine Hydrochloride M.D. Anderson Cancer Center|National Cancer Institute (NCI) Phase 3 2012-02-17
    NCT02855138 Adverse Effects of Medical Drugs Drug: oral isotretinoin Kayseri Education and Research Hospital|Kayseri Erciyes University Faculty of Medicine Phase 4 2015-01-01 2016-08-04
    NCT01139749 Seborrhea|Seborrheic Dermatitis|Quality of Life Drug: oral isotretinoin|Drug: salicylic acid and ciclopirox olamine Federal University of So Paulo Phase 4 2011-10-01 2011-10-09
    NCT01404130 Acne Vulgaris Drug: Isotretinoin University of Aberdeen Phase 4 2008-09-01 2011-07-26
    NCT00324740 Recurrent Renal Cell Cancer|Stage III Renal Cell Cancer|Stage IV Renal Cell Cancer Drug: vorinostat|Drug: isotretinoin National Cancer Institute (NCI) Phase 1|Phase 2 2006-03-01 2015-10-22
    NCT01863615 Skin Infections (Acne) Drug: Isotretinoin 40 mg|Drug: Isotretinoin 40 mg GlaxoSmithKline Phase 1 2011-08-01 2013-12-05
    NCT01560585 Alzheimer's Disease Drug: Isotretinoin University Hospitals Cleveland Medical Center Phase 1|Phase 2 2012-04-01 2014-08-27
    NCT02498288 Acne Vulgaris Drug: Isotretinoin: Reference Medication 1|Drug: Isotretinoin: Reference Medication 2|Drug: Isotretinoin: Test Medication GlaxoSmithKline Phase 1 2013-05-01 2015-07-13
    NCT01727440 Acne Vulgaris|Isotretinoin Duke University 2011-09-01 2017-01-30
    NCT01445028 Proliferative Vitreoretinopathy Drug: Isotretinoin Wills Eye Phase 4 2011-09-01 2013-06-18
    NCT00038376 Lymphoma, T-Cell|Mycosis Fungoides|Hematologic Neoplasms Drug: Isotretinoin (Accutane)|Drug: Interferon Alpha M.D. Anderson Cancer Center Phase 2 1990-05-01 2012-07-27
    NCT01969058 HIV-1 Infection Drug: Isotretinoin AIDS Clinical Trials Group|National Institute of Allergy and Infectious Diseases (NIAID) Phase 2 2014-07-01 2017-01-24
    NCT00098891 Adult Grade III Lymphomatoid Granulomatosis|Anaplastic Large Cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Intraocular Lymphoma|Nodal Marginal Zone B-cell Lymphoma|Primary Central Nervous System Non-Hodgkin Lymphoma|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Mixed Cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Adult Grade III Lymphomatoid Granulomatosis|Recurrent Adult Hodgkin Lymphoma|Recurrent Adult Immunoblastic Large Cell Lymphoma|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Adult T-cell Leukemia/Lymphoma|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Mycosis Fungoides/Sezary Syndrome|Recurrent Small Lymphocytic Lymphoma|Small Intestine Lymphoma|Splenic Marginal Zone Lymphoma|Stage IV Adult Burkitt Lymphoma|Stage IV Adult Diffuse Large Cell Lymphoma|Stage IV Adult Diffuse Mixed Cell Lymphoma|Stage IV Adult Diffuse Small Cleaved Cell Lymphoma|Stage IV Adult Hodgkin Lymphoma|Stage IV Adult Immunoblastic Large Cell Lymphoma|Stage IV Adult Lymphoblastic Lymphoma|Stage IV Adult T-cell Leukemia/Lymphoma|Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma|Stage IV Grade 1 Follicular Lymphoma|Stage IV Grade 2 Follicular Lymphoma|Stage IV Grade 3 Follicular Lymphoma|Stage IV Mantle Cell Lymphoma|Stage IV Marginal Zone Lymphoma|Stage IV Mycosis Fungoides/Sezary Syndrome|Stage IV Small Lymphocytic Lymphoma|Unspecified Adult Solid Tumor, Protocol Specific|Waldenstrm Macroglobulinemia Drug: entinostat|Drug: isotretinoin National Cancer Institute (NCI) Phase 1 2004-10-01 2013-01-23
    NCT00882531 Papular-pustular Rosacea Drug: isotretinoin|Drug: placebo Laboratoires Bailleul-Biorga|Quanta Medical Phase 3 2007-02-01 2009-11-16
    NCT00975143 Severe Nodular Acne Drug: CIP-Isotretinoin|Drug: Isotretinoin Cipher Pharmaceuticals Inc. Phase 3 2009-09-01 2014-06-05
    NCT03076021 CYP2D6 Polymorphism Drug: Isotretinoin|Drug: dextromethorphan University of Washington|National Institute of General Medical Sciences (NIGMS) Phase 4 2016-07-26 2017-03-06
    NCT00701740 Photoaging|Epidermal p53 Expression Drug: oral isotretinoin and Mexoryl SX / XL|Drug: Mexoryl XL / SX Federal University of So Paulo Phase 2 2007-07-01 2008-06-18
    NCT00842907 Photodamage|Photoaging Drug: oral isotretinoin|Drug: Tretinoin Federal University of So Paulo Phase 2 2009-05-01 2010-06-07
    NCT00334789 Adult Solid Neoplasm Drug: Belinostat|Drug: Isotretinoin|Other: Pharmacological Study National Cancer Institute (NCI) Phase 1 2006-06-01 2016-12-26

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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