Isotretinoin (异维A酸; 13-cis-Retinoic acid) 可作用于重度粉刺,还可用于脑癌,胰腺癌等化疗。
It was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Webster WS, et al. J Craniofac Genet Dev Biol, 1986, 6(3), 211-222.
分子式 C20H28O2 |
分子量 300.44 |
CAS号 4759-48-2 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 58 mg/mL |
Water <1 mg/mL |
Ethanol 25 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated | |
NCT01319838 | Neuroblastoma | Drug: Isotretinoin | Emory University|Children's Healthcare of Atlanta | Phase 1 | 2011-03-01 | 2013-12-09 | |
NCT01888328 | Healthy | Drug: Isotretinoin | Dr. Reddy's Laboratories Limited | Phase 1 | 2001-05-01 | 2013-06-26 | |
NCT01888341 | Healthy | Drug: Isotretinoin | Dr. Reddy's Laboratories Limited | Phase 1 | 2002-08-01 | 2013-06-26 | |
NCT01888289 | Healthy | Drug: Isotretinoin | Dr. Reddy's Laboratories Limited | Phase 1 | 2001-07-01 | 2013-06-26 | |
NCT01888224 | Healthy | Drug: Isotretinoin | Dr. Reddy's Laboratories Limited | Phase 1 | 2011-06-01 | 2013-06-25 | |
NCT02457520 | Acne | Drug: Isotretinoin | Ranbaxy Inc. | Phase 4 | 2015-01-01 | 2015-05-28 | |
NCT00003564 | Brain and Central Nervous System Tumors | Drug: Isotretinoin|Drug: Procarbazine Hydrochloride | M.D. Anderson Cancer Center|National Cancer Institute (NCI) | Phase 3 | 2012-02-17 | ||
NCT02855138 | Adverse Effects of Medical Drugs | Drug: oral isotretinoin | Kayseri Education and Research Hospital|Kayseri Erciyes University Faculty of Medicine | Phase 4 | 2015-01-01 | 2016-08-04 | |
NCT01139749 | Seborrhea|Seborrheic Dermatitis|Quality of Life | Drug: oral isotretinoin|Drug: salicylic acid and ciclopirox olamine | Federal University of So Paulo | Phase 4 | 2011-10-01 | 2011-10-09 | |
NCT01404130 | Acne Vulgaris | Drug: Isotretinoin | University of Aberdeen | Phase 4 | 2008-09-01 | 2011-07-26 | |
NCT00324740 | Recurrent Renal Cell Cancer|Stage III Renal Cell Cancer|Stage IV Renal Cell Cancer | Drug: vorinostat|Drug: isotretinoin | National Cancer Institute (NCI) | Phase 1|Phase 2 | 2006-03-01 | 2015-10-22 | |
NCT01863615 | Skin Infections (Acne) | Drug: Isotretinoin 40 mg|Drug: Isotretinoin 40 mg | GlaxoSmithKline | Phase 1 | 2011-08-01 | 2013-12-05 | |
NCT01560585 | Alzheimer's Disease | Drug: Isotretinoin | University Hospitals Cleveland Medical Center | Phase 1|Phase 2 | 2012-04-01 | 2014-08-27 | |
NCT02498288 | Acne Vulgaris | Drug: Isotretinoin: Reference Medication 1|Drug: Isotretinoin: Reference Medication 2|Drug: Isotretinoin: Test Medication | GlaxoSmithKline | Phase 1 | 2013-05-01 | 2015-07-13 | |
NCT01727440 | Acne Vulgaris|Isotretinoin | Duke University | 2011-09-01 | 2017-01-30 | |||
NCT01445028 | Proliferative Vitreoretinopathy | Drug: Isotretinoin | Wills Eye | Phase 4 | 2011-09-01 | 2013-06-18 | |
NCT00038376 | Lymphoma, T-Cell|Mycosis Fungoides|Hematologic Neoplasms | Drug: Isotretinoin (Accutane)|Drug: Interferon Alpha | M.D. Anderson Cancer Center | Phase 2 | 1990-05-01 | 2012-07-27 | |
NCT01969058 | HIV-1 Infection | Drug: Isotretinoin | AIDS Clinical Trials Group|National Institute of Allergy and Infectious Diseases (NIAID) | Phase 2 | 2014-07-01 | 2017-01-24 | |
NCT00098891 | Adult Grade III Lymphomatoid Granulomatosis|Anaplastic Large Cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Intraocular Lymphoma|Nodal Marginal Zone B-cell Lymphoma|Primary Central Nervous System Non-Hodgkin Lymphoma|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Mixed Cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Adult Grade III Lymphomatoid Granulomatosis|Recurrent Adult Hodgkin Lymphoma|Recurrent Adult Immunoblastic Large Cell Lymphoma|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Adult T-cell Leukemia/Lymphoma|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Mycosis Fungoides/Sezary Syndrome|Recurrent Small Lymphocytic Lymphoma|Small Intestine Lymphoma|Splenic Marginal Zone Lymphoma|Stage IV Adult Burkitt Lymphoma|Stage IV Adult Diffuse Large Cell Lymphoma|Stage IV Adult Diffuse Mixed Cell Lymphoma|Stage IV Adult Diffuse Small Cleaved Cell Lymphoma|Stage IV Adult Hodgkin Lymphoma|Stage IV Adult Immunoblastic Large Cell Lymphoma|Stage IV Adult Lymphoblastic Lymphoma|Stage IV Adult T-cell Leukemia/Lymphoma|Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma|Stage IV Grade 1 Follicular Lymphoma|Stage IV Grade 2 Follicular Lymphoma|Stage IV Grade 3 Follicular Lymphoma|Stage IV Mantle Cell Lymphoma|Stage IV Marginal Zone Lymphoma|Stage IV Mycosis Fungoides/Sezary Syndrome|Stage IV Small Lymphocytic Lymphoma|Unspecified Adult Solid Tumor, Protocol Specific|Waldenstrm Macroglobulinemia | Drug: entinostat|Drug: isotretinoin | National Cancer Institute (NCI) | Phase 1 | 2004-10-01 | 2013-01-23 | |
NCT00882531 | Papular-pustular Rosacea | Drug: isotretinoin|Drug: placebo | Laboratoires Bailleul-Biorga|Quanta Medical | Phase 3 | 2007-02-01 | 2009-11-16 | |
NCT00975143 | Severe Nodular Acne | Drug: CIP-Isotretinoin|Drug: Isotretinoin | Cipher Pharmaceuticals Inc. | Phase 3 | 2009-09-01 | 2014-06-05 | |
NCT03076021 | CYP2D6 Polymorphism | Drug: Isotretinoin|Drug: dextromethorphan | University of Washington|National Institute of General Medical Sciences (NIGMS) | Phase 4 | 2016-07-26 | 2017-03-06 | |
NCT00701740 | Photoaging|Epidermal p53 Expression | Drug: oral isotretinoin and Mexoryl SX / XL|Drug: Mexoryl XL / SX | Federal University of So Paulo | Phase 2 | 2007-07-01 | 2008-06-18 | |
NCT00842907 | Photodamage|Photoaging | Drug: oral isotretinoin|Drug: Tretinoin | Federal University of So Paulo | Phase 2 | 2009-05-01 | 2010-06-07 | |
NCT00334789 | Adult Solid Neoplasm | Drug: Belinostat|Drug: Isotretinoin|Other: Pharmacological Study | National Cancer Institute (NCI) | Phase 1 | 2006-06-01 | 2016-12-26 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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