Iloperidone

伊潘立酮,伊洛培酮,HP-873,HP 873,Fanapt,Zomaril,HP873,

Iloperidone是D2/5-HT2受体拮抗剂,可作用于精神分裂症。

目录号
EY1771
EY1771
EY1771
EY1771
纯度
99.25%
99.25%
99.25%
99.25%
规格
5 mg
10 mg
50 mg
100 mg
原价
315
505
1889
3290
售价
315
505
1889
3290
库存
现货
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Iloperidone is a dopamine (D2)/serotonin (5-HT2) receptor antagonist, used for the treatment of schizophrenia.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Kalkman HO, et al. Neuropsychopharmacology, 2001, 25(6), 904-914.

    分子式
    C24H27FN2O4
    分子量
    426.48
    CAS号
    133454-47-4
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    26 mg/mL
    Water
    <1 mg/mL
    Ethanol
    3 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01495169 Safety and Tolerability of Iloperidone Drug: iloperidone (oral tablet) Vanda Pharmaceuticals Phase 1 2011-10-01 2016-06-10
    NCT01207414 Schizophrenia Drug: iloperidone Novartis Phase 4 2010-08-01 2013-02-04
    NCT02413918 Bipolar Disorder Drug: iloperidone The University of Texas Health Science Center at San Antonio|Novartis Pharmaceuticals Phase 4 2012-04-01 2015-04-09
    NCT01529294 Hepatic Impairment Drug: Iloperidone Novartis Pharmaceuticals|Novartis Phase 1 2010-08-01 2013-03-13
    NCT01917318 Post Traumatic Stress Disorder Drug: Iloperidone|Drug: Placebo University of Colorado, Denver|Novartis Pharmaceuticals Phase 2 2013-07-01 2014-09-24
    NCT01929889 Schizophrenia|Schizoaffective Disorder Drug: Iloperidone Northwestern University|Novartis Pharmaceuticals Phase 4 2012-04-01 2015-07-06
    NCT01623713 Schizophrenia|Iloperidone|Efficacy Drug: iloperidone|Drug: Risperidone Jiangsu Hansoh Pharmaceutical Co., Ltd. Phase 2 2012-06-01 2013-11-17
    NCT01348100 Schizophrenia Drug: Iloperidone crystalline formulation|Drug: Iloperidone microparticle formulation|Drug: Oral iloperidone Novartis Pharmaceuticals|Vanda Pharmaceuticals|Novartis Phase 1|Phase 2 2011-04-01 2013-12-17
    NCT01291511 Schizophrenia Drug: Iloperidone|Drug: Placebo Vanda Pharmaceuticals Phase 3 2011-02-01 2016-06-10
    NCT01464229 Major Depressive Disorder Drug: Iloperidone|Drug: Placebo Maurizio Fava, MD|Novartis Pharmaceuticals|Massachusetts General Hospital Phase 4 2012-04-01 2015-04-14
    NCT01920802 Healthy Drug: olanzapine|Drug: iloperidone|Drug: Placebo New York State Psychiatric Institute|Novartis Pharmaceuticals Phase 4 2012-11-01 2017-01-30
    NCT02453893 Schizophrenia Drug: Iloperidone|Drug: Risperidone CSPC ZhongQi Pharmaceutical Technology Co., Ltd. Phase 3 2013-11-01 2015-05-26
    NCT01686815 Schizophrenia|Serious Mental Illness|Metabolic Syndrome|Insulin Resistance|Glucose Metabolism David C. Henderson|Novartis Pharmaceuticals|Massachusetts General Hospital 2012-10-01 2015-04-15
    NCT00254202 Schizophrenia Drug: iloperidone|Drug: active comparator|Drug: placebo Vanda Pharmaceuticals Phase 3 2005-11-01 2012-07-18
    NCT00806234 Psychotic Disorders Drug: Aripiprazole or Perphenazine|Drug: Metformin|Drug: Olanzapine, quetiapine, risperidone, ziprasidone, aripiprazole, asenapine, iloperidone, lurasidone, paliperidone, or olanzapine/fluoxetine Johns Hopkins University|National Institute of Mental Health (NIMH)|University of Maryland|University of North Carolina, Chapel Hill|The Zucker Hillside Hospital Phase 4 2009-01-01 2014-05-15
    NCT01498770 Bipolar Disorder Drug: Asenapine|Drug: Aripiprazole|Drug: Quetiapine|Drug: Risperidone|Drug: Olanzapine|Drug: Ziprasidone|Drug: Iloperidone|Drug: Paliperidone|Drug: Lurasidone|Drug: Clozapine|Drug: Amisulpride|Drug: Sertindole|Drug: Zotepine Merck Sharp & Dohme Corp. 2013-04-01 2017-03-06
    NCT02181803 Schizophrenia Drug: MK-8189|Drug: Placebo|Drug: Base Monotherapy Merck Sharp & Dohme Corp. Phase 1 2014-08-01 2015-05-05
    NCT02600741 Schizophrenia Other: Caregiver psycho-education and skills training|Other: Caregiver support available at the study site|Drug: Paliperidone palmitate|Drug: Chlorpromazine|Drug: Droperidol|Drug: Fluphenazine|Drug: Haloperidol|Drug: Loxapine|Drug: Perphenazine|Drug: Pimozide|Drug: Prochlorperazine|Drug: Thiothixene|Drug: Thioridazine|Drug: Trifluoperazine|Drug: Aripiprazole|Drug: Asenapine|Drug: Clozapine|Drug: Iloperidone|Drug: Olanzapine|Drug: Paliperidone|Drug: Quetiapine|Drug: Risperidone|Drug: Ziprasidone Janssen Scientific Affairs, LLC 2015-07-24 2017-03-17
    NCT02191358 Adverse Drug Events|Adverse Drug Reactions|Drug Interaction Potentiation|Drug Metabolism, Poor, CYP2D6-RELATED|Drug Metabolism, Poor, CYP2C19-RELATED|Cytochrome P450 Enzyme Deficiency|Cytochrome P450 CYP2D6 Enzyme Deficiency|Cytochrome P450 CYP2C9 Enzyme Deficiency|Cytochrome P450 CYP2C19 Enzyme Deficiency|Cytochrome P450 CYP3A Enzyme Deficiency|Poor Metabolizer Due to Cytochrome P450 CYP2C9 Variant|Poor Metabolizer Due to Cytochrome P450 CYP2C19 Variant|Poor Metabolizer Due to Cytochrome P450 CYP2D6 Variant Genelex Corporation|University of Utah 2014-10-01 2017-02-27

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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