L-Epinephrine Bitartrate是α和β肾上腺素受体刺激剂,是一种激素和神经递质。
Epinephrine Bitartrate is an alpha- and beta-adrenergic receptor stimulator.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Fabiano B Carvalho et. Al. The Journal of Nutritional Biochemistry, 26(4), 378-390 (2015).
[2] Yangjie Wei et. Al. AAPS PharmSciTech, 16(2), 455-465 (2015).
分子式 C13H19NO9 |
分子量 333.29 |
CAS号 51-42-3 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 66 mg/mL |
Water 66 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01432522 | Anaphylaxis | Drug: Epinephrine | Siriraj Hospital|Mahidol University | 2010-07-01 | 2011-09-12 | |
NCT01217138 | Anaphylaxis | Device: Epinephrine autoinjector | Gazi University | Phase 4 | 2009-06-01 | 2010-10-07 |
NCT01887405 | Handling of Auto-injectors | Drug: Adrenaline auto-injector | ALK Nordic A/S, Danmark Filial | Phase 4 | 2012-01-01 | 2013-06-24 |
NCT03036202 | Cardiac Arrest | Drug: Epinephrine | Haukeland University Hospital | 2017-02-10 | 2017-02-06 | |
NCT00997594 | Adrenal Tumors | Procedure: Radiofrequency ablation | Mie University | Phase 2|Phase 3 | 2009-10-01 | 2015-04-06 |
NCT00548886 | Congenital Disorders | Drug: Epinephrine | Emory University|Children's Healthcare of Atlanta | 2008-02-01 | 2015-02-20 | |
NCT01209507 | Adrenal Suppression | Other: Chemotherapy | University of Colorado, Denver | 2010-02-01 | 2017-03-23 | |
NCT00768365 | Adrenal Cortex Neoplasms | Istanbul University | 2007-10-01 | 2008-10-07 | ||
NCT01188577 | Asthma|Bronchospasm|Wheezing|Shortness of Breath | Drug: Epinephrine Inhalation Aerosol, HFA|Drug: Epinephrine Inhalation Aerosol | Amphastar Pharmaceuticals, Inc. | Phase 1|Phase 2 | 2010-08-01 | 2014-10-21 |
NCT00975078 | Adrenal Gland Hypofunction | Procedure: adrenal insufficiency testing|Drug: prednisone | University Hospital, Basel, Switzerland | Phase 4 | 2009-05-01 | 2011-08-08 |
NCT01264653 | Cataract | Drug: adrenalin | Wenzhou Medical University | 2010-12-01 | 2012-07-04 | |
NCT01664507 | Croup|Epinephrine Neublizer Treatment | Drug: conventional dose epinephrine|Drug: low dose epinephrine | Seoul National University Hospital | Phase 4 | 2012-09-01 | 2012-08-09 |
NCT00591643 | Adrenal Tumors|Adrenal Malignancies|Abnormal Hormonal Secretions|Electrolytes Abnormalities | Procedure: Imaging, Adrenal acans|Radiation: (NP-59) | Memorial Sloan Kettering Cancer Center | Phase 1 | 1977-07-01 | 2015-12-23 |
NCT02368379 | Prader Willi Syndrome|Adrenal Insufficiency | Other: Low dose (1 mcg) ACTH stimulation test|Other: Overnight metyrapone test | Nationwide Children's Hospital | 2014-03-01 | 2015-02-16 | |
NCT00721929 | Adrenal Gland Disease | Procedure: MRI | University of Michigan | 2003-10-01 | 2012-12-04 | |
NCT02735018 | Cardiovascular Response to Epinephrine | Drug: Epinephrine 1:100,000|Drug: Epinephrine 1:200,000 | Rio de Janeiro State University | Phase 4 | 2014-12-01 | 2016-04-06 |
NCT00575029 | Adrenal Insufficiency | Drug: megestrol acetate | University of Arkansas | 2004-04-01 | 2011-07-27 | |
NCT02692313 | Diabetes Complications | Drug: Epinephrine|Other: Saline infusion | University of Maryland|Vanderbilt University | Early Phase 1 | 2016-06-01 | 2017-02-09 |
NCT02694926 | Adrenal Insufficiency | Other: Education | Wuerzburg University Hospital|Dr. Michael Droste, Elisenstrae 12, 26122 Oldenburg|Prof. Dr. Marcus Quinkler, Praxis fr Endokrinologie,10627 Berlin|Dr. Gesine Meyer, Universittsklinikum Frankfurt, 60590 Frankfurt am Main|PD Dr. Nicole Reisch, LMU Mnchen, D-80336 Mnchen|Prof. Dr. Holger Willenberg, Zentrum fr Innere Medizin, D-18057 Rostock|Prof. Johannes Klein, Zentrum Endokrine Medizin, 23564 Lbeck|Dr. med. Tina Kienitz, Charit - Universittsmedizin Berlin, 10117 Berlin|MVZ Endokrinologikum Saarbrcken, Europaallee 15, 66113 Saarbrcken | 2014-12-01 | 2016-03-02 | |
NCT01284829 | Adrenal Tumors | Other: FDG-PET scan | Assistance Publique Hopitaux De Marseille | 2011-02-01 | 2015-09-29 | |
NCT02543697 | Cushing Syndrome | Radiation: Adrenal venous sampling | Haukeland University Hospital | 2015-02-01 | 2016-09-07 | |
NCT00628550 | Cardiopulmonary Arrest|Cardiac Arrest | Drug: Vasopressin|Drug: Epinephrine | University of Texas Southwestern Medical Center|Children's Medical Center Dallas | Phase 1 | 2008-04-01 | 2010-06-24 |
NCT02724761 | Dysphagia|Dysphonia|Postoperative Pain | Drug: Racemic Epinephrine|Drug: Placebo (for racemic epinephrine) | Andrew Chung|More Foundation|Banner Health | 2016-09-01 | 2016-03-30 | |
NCT02369510 | Spinal Anesthesia|Cesarean Section | Drug: Low-dose epinephrine|Drug: High-dose epinephrine|Drug: No epinephrine | Icahn School of Medicine at Mount Sinai | Phase 4 | 2015-02-01 | 2016-07-21 |
NCT02127840 | Primary Aldosteronism | Drug: Synacthen infusion during adrenal venous sampling | Charles University, Czech Republic|University Hospital Hradec Kralove | Phase 4 | 2011-03-01 | 2014-04-28 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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