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Bacitracin

杆菌肽,枯草菌肽,亚枯草菌素

Bacitracin是由Bacillus subtilis var生物体产生的相关环状多肽组成的混合物，通过干扰细胞壁肽聚糖的合成，从而破坏革兰氏阳性和革兰氏阴性细菌。

目录号
EY1766
EY1766
纯度
99.47%
99.47%
规格
100 mg
1 g
原价
450
660
售价
450
660
库存
现货
现货
订购
订购
订购
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  • 生物活性

    Bacitracin is a mixture of related cyclic polypeptides produced by organisms of the licheniformis group of Bacillus subtilis var Tracy, which disrupts both gram positive and gram negative bacteria by interfering with cell wall and peptidoglycan synthesis.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Toscano WA Jr, et al. Pharmacol Ther, 1982, 16(2), 199-210.

    分子式
    C65H101N17O16S    		 分子量
    1408.67    		 CAS号
    1405-87-4    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    100 mg/mL    		 Water
    100 mg/mL    		 Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00132600 Allergic Contact Dermatitis Drug: bacitracin (allergen) Mekos Laboratories AS Phase 2 2005-04-01 2005-10-18
    NCT02106962 Native Arteriovenous Fistula Drug: Topical Tranexamic Acid|Drug: Topical Bacitracin California Institute of Renal Research|Imprimis Pharmaceuticals, Inc. Phase 4 2014-04-01 2014-04-09
    NCT01516463 Burn, Partial Thickness Drug: Collagenase Santyl|Biological: Bacitracin Healthpoint Phase 4 2012-03-01 2012-05-15
    NCT02673229 Burn, Partial Thickness Drug: Collagenase Santyl|Drug: Bacitracin University of Kansas Medical Center|Healthpoint Phase 4 2014-01-01 2016-09-22
    NCT01222832 Sinus Disease Drug: Bacitracin Steward St. Elizabeth's Medical Center of Boston, Inc. Phase 2 2010-07-01 2014-01-02
    NCT00479193 Burns Drug: Polymem|Drug: Polymem MetroHealth Medical Center Phase 1 2006-10-01 2008-01-24
    NCT00671541 Chronic Sinusitis Drug: Merogel Nasal Stent and Nasopore Stent|Drug: Nasopore Stent and either Gentamycin or Bacitracin Lahey Clinic Phase 4 2006-03-01 2012-02-16
    NCT01350102 Diabetes, Type 1|Diabetes, Type 2|Foot Ulcer, Diabetic Drug: Bacitracin|Drug: AmeriGel|Procedure: Hemoglobin A1c|Dietary Supplement: Vitamin C Susan Hassenbein|Milton S. Hershey Medical Center Phase 4 2012-02-01 2015-05-06
    NCT01359735 Non-melanoma Skin Cancer Biological: HP802-247|Biological: Bacitracin Ointment Healthpoint Phase 2 2011-05-01 2013-09-19
    NCT00640614 Contact Dermatitis Biological: T.R.U.E. TEST Skin Patch Test: Dose Response Allergens Allerderm Phase 3 2008-04-01 2015-11-18
    NCT00705354 Sinusitis|Chronic Sinusitis Drug: Bacitracin|Procedure: Nasopore sponge soaked with saline Lahey Clinic 2009-01-01 2012-04-12
    NCT01668030 Burns Drug: Collagenase versus Bacitracin University of Louisville|Healthpoint Phase 4 2012-04-01 2012-08-16
    NCT02395614 Breast Cancer Drug: Chlorhexidine irrigation|Drug: triple antibiotic irrigation Vanderbilt University 2015-12-01 2016-11-10
    NCT00674999 Burn Biological: Amnion|Biological: Amnion|Drug: Polysporin/Bacitracin/Mycostatin The University of Texas Medical Branch, Galveston Phase 2|Phase 3 2005-06-01 2012-11-13
    NCT01613092 Arrhythmia Drug: Incremental|Drug: Cefazolin Population Health Research Institute Phase 4 2011-05-01 2014-10-09
    NCT02318056 Burns Other: Aquacel Ag Burn Glove|Other: Mepilex Transfer Ag|Drug: antibiotic Southern Illinois University 2015-12-01 2016-07-20
    NCT01002911 Arrythmias Drug: Cefazolin, Bacitracin, Cefalexin|Drug: Cefazolin Population Health Research Institute Phase 3 2009-12-01 2013-05-14
    NCT01628666 Arrhythmia Drug: Incremental|Drug: Conventional Population Health Research Institute|Canadian Institutes of Health Research (CIHR) Phase 4 2012-12-01 2016-09-26
    NCT00997139 Nasal Carriers of Staphylococcus Aureus Drug: Neosporin (polymyxin B 5,000units, bacitracin 400 units, neomycin 3.5mg) Northwestern University 2009-09-01 2014-12-11
    NCT01518348 Contact Dermatitis Biological: Patch Test Allerderm Phase 3 2012-12-01 2013-02-26

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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