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Alfacalcidol

阿法骨化醇,1α-Hydroxyvitamin D3,1-alpha-hydroxycholecalciferol

Alfacalcidol (阿法骨化醇; 1-hydroxycholecalciferol; Alpha D3; 1.alpha.-Hydroxyvitamin D3) 是非选择性VDR活化剂。

目录号
EY1763
EY1763
EY1763
EY1763
EY1763
纯度
99.33%
99.33%
99.33%
99.33%
99.33%
规格
5 mg
10 mg
25 mg
50 mg
100 mg
原价
790
1180
2320
3720
5800
售价
790
1180
2320
3720
5800
库存
现货
现货
现货
现货
现货
订购
订购
订购
订购
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  • 生物活性

    Alfacalcidol is a non-selective VDR activator medication.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Koji Nakamura et. Al. International Journal of Gynecological Cancer, 25(2), 288-295 (2015).
    [2] Laurent Genser et. Al. The American Journal of Surgery, 207(1), 39-45 (2014).
    [3] Siobhan O'Donnell et. Al. Journal of Bone and Mineral Metabolism, 26(6), 531-542 (2008).

    分子式
    C27H44O2    		 分子量
    400.64    		 CAS号
    41294-56-8    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    80 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    50 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02327091 Muscle Weakness Drug: alfacalcidol Indonesia University Phase 3 2012-04-01 2014-12-29
    NCT01752244 Obesity Dietary Supplement: Placebo|Dietary Supplement: Alfacalcidol Tehran University of Medical Sciences 2012-01-01 2012-12-24
    NCT02895061 Alfacalcidol, Secondary Hyperparathyroidism, Hemodialysis Drug: Alfacalcidol Phramongkutklao College of Medicine and Hospital 2015-01-01 2016-09-04
    NCT01115543 Secondary Hyperparathyroidism|End Stage Renal Disease Drug: alfacalcidol and calcitriol Mahidol University Phase 4 2008-08-01 2010-05-01
    NCT00168909 Osteoporosis, Postmenopausal|Osteopenia|Falls Drug: alfacalcidol|Drug: placebo Charite University, Berlin, Germany Phase 4 2003-06-01 2008-05-08
    NCT01364688 Vascular Calcification Drug: oral alfacalcidol|Drug: no drug Ramathibodi Hospital Phase 2 2011-05-01 2011-05-31
    NCT01974167 Osteoporosis Drug: Eldecalcitol|Drug: Alfacalcidol e-GLORIA trial Protocol Review Committee 2013-12-01 2014-08-05
    NCT00828347 Secondary Hyperparathyroidism Drug: 1.0 g/day Alfacalcidol|Drug: 0.25 g/day Alfacalcidol Kumamoto University 2008-01-01 2015-12-16
    NCT00483275 Accidental Falls|Chronic Renal Insufficiency|Aged Drug: Alfacalcidol|Behavioral: Balance, gait and strength training|Behavioral: Patient education Ruhr University of Bochum|Teva Pharmaceutical Industries Phase 4 2007-06-01 2011-07-20
    NCT00138983 Rheumatoid Arthritis|Polymyalgia Rheumatica|Giant Cell Arteritis|Polymyositis|Wegener Granulomatosis Drug: Alendronate versus alfacalcidol (1-alpha OH vitamin D) UMC Utrecht|Dutch Health Care Insurance Board Phase 3 2000-05-01 2006-11-28
    NCT00469599 Secondary Hyperparathyroidism|Chronic Kidney Disease|Vitamin D Deficiency Drug: paricalcitol|Drug: alfacalcidol Zealand University Hospital 2007-07-01 2011-04-01
    NCT01020253 Bone Density|Arthroplasty, Replacement, Hip Drug: alendronate, alfacalcidol Yokohama City University Medical Center 2006-01-01 2009-12-02
    NCT02747381 Asthma Dietary Supplement: Alfacalcidol Cairo University Phase 4 2014-08-01 2016-04-20
    NCT02824718 Autosomal Dominant Hypocalcemia Drug: Teriparatide|Drug: Thiazide|Drug: Potassium sparing diuretic|Drug: Alfacalcidol Assistance Publique - H么pitaux de Paris|Ministry of Health, France Phase 2 2016-09-01 2016-10-07
    NCT02993302 Graves Disease Drug: 1伪-D3|Drug: Placebos Dr Cipto Mangunkusumo General Hospital|Indonesia University Phase 2 2014-07-01 2016-12-12
    NCT00668330 Systemic Lupus Erythematosus Drug: Ibandronate+alfacalcidol+calcium|Drug: placebo ibandronate+alfacalcidol+calcium Chinese University of Hong Kong Phase 4 2007-04-01 2012-02-10
    NCT00144456 Osteoporosis Drug: ED-71|Drug: Alfacalcidol|Drug: ED-71 placebo|Drug: Alfacalcidol placebo Chugai Pharmaceutical Phase 3 2004-09-01 2013-08-06
    NCT00165698 Postmenopausal Osteoporosis Drug: menatetranone|Drug: alfacalcidol Eisai Co., Ltd.|Eisai Inc. Phase 3 2005-05-01 2014-07-11
    NCT01774812 Cardiovascular Disease|Sudden Cardiac Death Dietary Supplement: Alfacalcidol|Dietary Supplement: Ergocalciferol University of Calgary|Alberta Innovates Health Solutions|Canadian Institutes of Health Research (CIHR) Phase 2 2013-01-01 2016-08-29
    NCT02656121 PCOS Drug: Vitamin D|Drug: placebo Ain Shams University Phase 2 2016-02-01 2016-02-14
    NCT01896609 Chronic Hepatitis c Biological: Reiferon Retard in Arm 1|Drug: Bon one in Arm 3|Drug: Xerovirinc in Arm 2|Drug: Ribavirin in Arm 1 MinaPharm Pharmaceuticals Phase 4 2013-06-01 2013-07-10

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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