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Elesclomol

伊利司莫,STA-4783,STA 4783,STA4783

Elesclomol (STA-4783)是新型氧化应激诱导剂,能促肿瘤细胞凋亡。

目录号
EY1760
EY1760
EY1760
EY1760
纯度
99.43%
99.43%
99.43%
99.43%
规格
5 mg
10 mg
50 mg
100 mg
原价
590
930
1420
1920
售价
590
930
1420
1920
库存
现货
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Elesclomol (STA-4783) is a novel potent oxidative stress inducer that elicits pro-apoptosis events among tumor cells. Phase 3.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

    浓度10 mM, ~500 nM

  • 动物实验

    ~100 mg/kg静脉注射

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Kirshner JR, et al. Mol Cancer Ther, 2008, 7(8), 2319-2327.

    分子式
    C19H20N4O2S2
    分子量
    400.52
    CAS号
    488832-69-5
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    80 mg/mL
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00888615 Malignant Ovarian Mixed Epithelial Tumor|Ovarian Brenner Tumor|Ovarian Clear Cell Cystadenocarcinoma|Ovarian Endometrioid Adenocarcinoma|Ovarian Mucinous Cystadenocarcinoma|Ovarian Serous Cystadenocarcinoma|Recurrent Fallopian Tube Carcinoma|Recurrent Ovarian Carcinoma|Recurrent Primary Peritoneal Carcinoma|Undifferentiated Ovarian Carcinoma Drug: Elesclomol Sodium|Drug: Paclitaxel Gynecologic Oncology Group|National Cancer Institute (NCI) Phase 2 2010-12-01 2014-12-23
    NCT00827203 Metastatic Solid Tumors Drug: Elesclomol Sodium Synta Pharmaceuticals Corp. Phase 1 2009-01-01 2009-03-06
    NCT01280786 Acute Myeloid Leukemia Drug: Elesclomol Sodium Synta Pharmaceuticals Corp. Phase 1 2011-01-01 2014-01-31
    NCT00808418 Prostate Cancer Drug: Elesclomol Sodium|Drug: Docetaxel Synta Pharmaceuticals Corp. Phase 1 2008-11-01 2014-01-31
    NCT00522834 Melanoma Drug: Elesclomol (STA-4783)|Drug: Paclitaxel Synta Pharmaceuticals Corp. Phase 3 2007-08-01 2014-01-31
    NCT00088114 Neoplasms Drug: STA-4783/paclitaxel Synta Pharmaceuticals Corp. Phase 1 2003-01-01 2014-03-05
    NCT00084214 Melanoma Drug: STA-4783|Drug: Paclitaxel Synta Pharmaceuticals Corp. Phase 1|Phase 2 2004-05-01 2014-03-05
    NCT00088088 Stage IIIB Non-Small Cell Lung Cancer|Stage IV Non-Small Cell Lung Cancer Drug: Paclitaxel|Drug: Carboplatin|Drug: STA 4783 Synta Pharmaceuticals Corp. Phase 1|Phase 2 2004-03-01 2008-12-03
    NCT00087997 Soft Tissue Sarcoma Drug: STA-4783 Synta Pharmaceuticals Corp. Phase 2 2004-07-01 2006-06-19

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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