Elesclomol (STA-4783)是新型氧化应激诱导剂,能促肿瘤细胞凋亡。
Elesclomol (STA-4783) is a novel potent oxidative stress inducer that elicits pro-apoptosis events among tumor cells. Phase 3.
浓度10 mM, ~500 nM
~100 mg/kg静脉注射
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Kirshner JR, et al. Mol Cancer Ther, 2008, 7(8), 2319-2327.
分子式 C19H20N4O2S2 |
分子量 400.52 |
CAS号 488832-69-5 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 80 mg/mL |
Water <1 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT00888615 | Malignant Ovarian Mixed Epithelial Tumor|Ovarian Brenner Tumor|Ovarian Clear Cell Cystadenocarcinoma|Ovarian Endometrioid Adenocarcinoma|Ovarian Mucinous Cystadenocarcinoma|Ovarian Serous Cystadenocarcinoma|Recurrent Fallopian Tube Carcinoma|Recurrent Ovarian Carcinoma|Recurrent Primary Peritoneal Carcinoma|Undifferentiated Ovarian Carcinoma | Drug: Elesclomol Sodium|Drug: Paclitaxel | Gynecologic Oncology Group|National Cancer Institute (NCI) | Phase 2 | 2010-12-01 | 2014-12-23 |
NCT00827203 | Metastatic Solid Tumors | Drug: Elesclomol Sodium | Synta Pharmaceuticals Corp. | Phase 1 | 2009-01-01 | 2009-03-06 |
NCT01280786 | Acute Myeloid Leukemia | Drug: Elesclomol Sodium | Synta Pharmaceuticals Corp. | Phase 1 | 2011-01-01 | 2014-01-31 |
NCT00808418 | Prostate Cancer | Drug: Elesclomol Sodium|Drug: Docetaxel | Synta Pharmaceuticals Corp. | Phase 1 | 2008-11-01 | 2014-01-31 |
NCT00522834 | Melanoma | Drug: Elesclomol (STA-4783)|Drug: Paclitaxel | Synta Pharmaceuticals Corp. | Phase 3 | 2007-08-01 | 2014-01-31 |
NCT00088114 | Neoplasms | Drug: STA-4783/paclitaxel | Synta Pharmaceuticals Corp. | Phase 1 | 2003-01-01 | 2014-03-05 |
NCT00084214 | Melanoma | Drug: STA-4783|Drug: Paclitaxel | Synta Pharmaceuticals Corp. | Phase 1|Phase 2 | 2004-05-01 | 2014-03-05 |
NCT00088088 | Stage IIIB Non-Small Cell Lung Cancer|Stage IV Non-Small Cell Lung Cancer | Drug: Paclitaxel|Drug: Carboplatin|Drug: STA 4783 | Synta Pharmaceuticals Corp. | Phase 1|Phase 2 | 2004-03-01 | 2008-12-03 |
NCT00087997 | Soft Tissue Sarcoma | Drug: STA-4783 | Synta Pharmaceuticals Corp. | Phase 2 | 2004-07-01 | 2006-06-19 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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