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Tasquinimod

他喹莫德,ABR-215050,ABR215050,ABR 215050

Tasquinimod(ABR-215050)是喹啉-3-甲酰胺利诺胺类似物,具有抗血管生成和抗肿瘤活性。

目录号
EY1756
EY1756
EY1756
EY1756
纯度
99.14%
99.14%
99.14%
99.14%
规格
2 mg
5 mg
10 mg
50 mg
原价
950
1420
2360
6930
售价
950
1420
2360
6930
库存
现货
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Tasquinimod is an orally active antiangiogenic agent by allosterically inhibiting HDAC4 signalling. Phase 3.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

    ~30 mg/kg/dp.o.

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Isaacs JT, et al. Cancer Res.?013, 73(4), 1386-1399.

    分子式
    C20H17F3N2O4
    分子量
    406.36
    CAS号
    254964-60-8
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    80 mg/mL
    Water
    <1 mg/mL
    Ethanol
    10 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01234311 Prostate Cancer Drug: tasquinimod|Drug: Placebo Active Biotech AB Phase 3 2011-03-01 2015-10-02
    NCT02396368 Prostate Cancer|Bone-only Metastatic Castration-Resistant Prostate Cancer (CRPC) Drug: Tasquinimod|Radiation: Radium 223 Sidney Kimmel Comprehensive Cancer Center Phase 1 2015-03-01 2015-11-17
    NCT01048203 Healthy Drug: ABR-215050 Active Biotech AB Phase 1 2009-01-01 2014-08-26
    NCT01513733 Prostate Cancer Drug: tasquinimod|Drug: tasquinimod 0.25 mg; 0.5 mg|Drug: tasquinimod 0.25 mg; 0.5 mg; 1.0 mg Andrew J. Armstrong, MD|Duke University Phase 1 2012-01-01 2017-02-08
    NCT02159950 Hormone-Resistant Prostate Cancer|Metastatic Prostate Carcinoma|Recurrent Prostate Carcinoma|Stage IV Prostate Cancer Other: Laboratory Biomarker Analysis|Biological: Sipuleucel-T|Drug: Tasquinimod Roswell Park Cancer Institute|National Cancer Institute (NCI)|Active Biotech AB Phase 2 2015-01-01 2016-05-19
    NCT01743469 Advanced or Metastatic Hepatocellular Cancer|Advanced or Metastatic Ovarian Cancer|Metastatic Renal Cell Cancer|Advanced or Metastatic Gastric Carcinoma Drug: Tasquinimod Ipsen Phase 2 2012-12-01 2016-03-31
    NCT01732549 Metastatic Castrate Resistant Prostate Cancer Drug: Tasquinimod|Drug: Placebo Ipsen Phase 2 2013-01-01 2016-08-09
    NCT02057666 Asian Chemo-nave Patients With Metastatic Castrate-resistant Prostate Cancer Drug: Tasquinimod|Drug: Placebo Ipsen Phase 3 2014-01-01 2015-06-29
    NCT00560482 Prostate Cancer Drug: ABR-215050, tasquinimod|Drug: Placebo Active Biotech AB Phase 2 2007-12-01 2015-10-02

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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