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Azathioprine

硫唑嘌呤,硝基咪唑硫嘌呤,义美仁,咪唑硫嘌呤

Azathioprine (硫唑嘌呤; Azasan, Imuran; BW 57-322) 是免疫抑制剂。

目录号
EY1746
EY1746
EY1746
纯度
99.54%
99.54%
99.54%
规格
500 mg
1 g
5 g
原价
390
521
925
售价
390
521
925
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Azathioprine is an immunosuppressive drug, inhibiting purine synthesis and GTP-binding protein Rac1 activation, used in the treatment of organ transplantation and autoimmune diseases.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Tiede I, et al. J Clin Invest, 2003, 111(8), 1133-1145.

    分子式
    C9H7N7O2S
    分子量
    277.26
    CAS号
    446-86-6
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    55 mg/mL
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00608894 Autoimmune Hepatitis Drug: LCP-Tacro (tacrolimus)|Drug: Azathioprine Veloxis Pharmaceuticals Phase 2 2007-12-01 2014-12-18
    NCT03002038 Neuromyelitis Optica Spectrum Disorder Drug: Azathioprine|Drug: Rituximab Isfahan University of Medical Sciences Phase 2|Phase 3 2015-09-01 2016-12-30
    NCT01381432 Liver Diseases Drug: Azathioprine GlaxoSmithKline 2004-12-01 2013-05-09
    NCT01390766 Liver Diseases Drug: Azathioprine GlaxoSmithKline 2002-08-01 2012-08-30
    NCT00849368 Inflammatory Bowel Disease Drug: Azathioprine / Allopurinol University of Zurich Phase 1 2009-01-01 2012-02-06
    NCT00525473 Azathioprine|Thiopurine Methyltransferase|Inosine Triphosphate Pyrophosphatase|Genetic Polymorphism Drug: Azathioprine National Taiwan University Hospital 2007-02-01 2012-05-16
    NCT03026907 Hand Eczema Drug: Alitretinoin|Drug: Azathioprine University Medical Center Groningen Phase 3 2016-05-01 2017-01-18
    NCT00098111 Crohn's Disease Drug: azathioprine Massachusetts General Hospital Phase 3 2005-04-01 2014-02-19
    NCT01817972 Crohn's Disease Biological: Certolizumab pegol|Drug: Azathioprine Gastroenterology Research of America|UCB Pharma Phase 3 2013-03-01 2013-03-21
    NCT01172002 Nephritis|Lupus Drug: Leflunomide|Drug: Azathioprine RenJi Hospital|Changhai Hospital|Shanghai 10th People's Hospital|Shanghai Zhongshan Hospital|The First Affiliated Hospital with Nanjing Medical University|The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School|The First Affiliated Hospital of Soochow University|Zhejiang University|Second Affiliated Hospital, School of Medicine, Zhejiang University|First Affiliated Hospital of Wenzhou Medical Univeristy|Qilu Hospital|AnHui ShengLi Hospital|First Affiliated Hospital Bengbu Medical College|The First Affiliated Hospital of Anhui Medical University 2010-03-01 2010-08-10
    NCT00504244 Systemic Lupus Erythematosus Drug: switch to Myfortic|Drug: continuation of azathioprine Erasmus Medical Center|Novartis Pharmaceuticals Phase 3 2007-07-01 2010-11-15
    NCT02247258 Crohn Disease|Recurrence|Azathioprine|Prevention Drug: Azathioprine|Drug: Azathioprine in case of endoscopic recurrence|Procedure: Ileocolonoscopy|Procedure: Small bowel follow trough Universitaire Ziekenhuizen Leuven|International organization for the study of inflammatory bowel disease (IOIBD) Phase 2 2005-10-01 2015-05-28
    NCT00626678 Pemphigus Vulgaris Drug: Azathioprine|Drug: Prednisone|Drug: Placebo Tehran University of Medical Sciences Phase 2 2008-01-01 2010-11-26
    NCT00976690 Crohn Disease Drug: Azathioprine OR Mesalazine Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives Phase 3 2002-10-01 2011-08-30
    NCT00946946 Crohn's Disease Drug: Azathioprine|Drug: Mesalazine|Drug: Azathioprine placebo|Drug: Mesalazine placebo Dr. Falk Pharma GmbH Phase 3 2002-02-01 2012-06-25
    NCT02789397 Granulomatous and Lymphocytic Interstitial Lung Disease Drug: Rituximab (RTX) and Azathioprine (AZA)|Drug: Placebo Administration Medical College of Wisconsin Phase 2 2016-07-01 2016-06-07
    NCT00204022 Lupus Nephritis Drug: Mycophenolate mofetil|Drug: Azathioprine Frdric A. Houssiau, MD, PhD|Universit Catholique de Louvain Phase 3 2001-02-01 2011-10-13
    NCT01392833 IgA Nephropathy|Chronic Kidney Disease Drug: methylprednisolone|Drug: azathioprine|Drug: prednisone A. Manzoni Hospital Phase 3 1999-12-01 2011-07-12
    NCT02425852 Ulcerative Colitis Drug: Azathioprine|Drug: Infliximab|Drug: Prednisolone|Drug: Hydrocortisone Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives Phase 4 2015-09-01 2015-04-23
    NCT02900443 Autoimmune Hepatitis Drug: Mycophenolate mofetil|Drug: Azathioprine Radboud University|Leiden University Medical Center Phase 4 2017-01-01 2017-01-09
    NCT02949349 Lupus Nephritis Drug: Mycophenolate mofetil|Drug: Azathioprine|Drug: Prednisolone Genovate Biotechnology Co., Ltd., Phase 2 2015-07-01 2017-03-01
    NCT01697267 Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis|Microscopic Polyangiitis|Wegener Granulomatosis Biological: Rituximab|Drug: Azathioprine Cambridge University Hospitals NHS Foundation Trust|Arthritis Research UK|Roche Pharma AG|Genentech, Inc.|University of Pennsylvania Phase 3 2013-04-01 2017-02-21
    NCT00755859 IGA Nephropathy Drug: steroids plus azathioprine|Drug: steroids A. Manzoni Hospital Phase 4 1998-05-01 2008-09-18
    NCT00321906 Delayed Graft Function|Acute Graft Rejection Drug: azathioprine|Drug: sirolimus University of Chicago|Astellas Pharma Inc|Loyola University|University of Florida|University of Pennsylvania|Baylor College of Medicine|Ochsner Health System|Columbia University|University of Wisconsin, Madison Phase 4 2002-04-01 2016-09-19
    NCT01112215 Systemic Lupus Erythematosus Drug: Azathioprine|Drug: Enteric-Coated Mycophenolate Sodium Hospital Universitari Vall d'Hebron Research Institute Phase 4 2009-12-01 2016-10-03

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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