Azathioprine (硫唑嘌呤; Azasan, Imuran; BW 57-322) 是免疫抑制剂。
Azathioprine is an immunosuppressive drug, inhibiting purine synthesis and GTP-binding protein Rac1 activation, used in the treatment of organ transplantation and autoimmune diseases.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Tiede I, et al. J Clin Invest, 2003, 111(8), 1133-1145.
分子式 C9H7N7O2S |
分子量 277.26 |
CAS号 446-86-6 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 55 mg/mL |
Water <1 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT00608894 | Autoimmune Hepatitis | Drug: LCP-Tacro (tacrolimus)|Drug: Azathioprine | Veloxis Pharmaceuticals | Phase 2 | 2007-12-01 | 2014-12-18 |
NCT03002038 | Neuromyelitis Optica Spectrum Disorder | Drug: Azathioprine|Drug: Rituximab | Isfahan University of Medical Sciences | Phase 2|Phase 3 | 2015-09-01 | 2016-12-30 |
NCT01381432 | Liver Diseases | Drug: Azathioprine | GlaxoSmithKline | 2004-12-01 | 2013-05-09 | |
NCT01390766 | Liver Diseases | Drug: Azathioprine | GlaxoSmithKline | 2002-08-01 | 2012-08-30 | |
NCT00849368 | Inflammatory Bowel Disease | Drug: Azathioprine / Allopurinol | University of Zurich | Phase 1 | 2009-01-01 | 2012-02-06 |
NCT00525473 | Azathioprine|Thiopurine Methyltransferase|Inosine Triphosphate Pyrophosphatase|Genetic Polymorphism | Drug: Azathioprine | National Taiwan University Hospital | 2007-02-01 | 2012-05-16 | |
NCT03026907 | Hand Eczema | Drug: Alitretinoin|Drug: Azathioprine | University Medical Center Groningen | Phase 3 | 2016-05-01 | 2017-01-18 |
NCT00098111 | Crohn's Disease | Drug: azathioprine | Massachusetts General Hospital | Phase 3 | 2005-04-01 | 2014-02-19 |
NCT01817972 | Crohn's Disease | Biological: Certolizumab pegol|Drug: Azathioprine | Gastroenterology Research of America|UCB Pharma | Phase 3 | 2013-03-01 | 2013-03-21 |
NCT01172002 | Nephritis|Lupus | Drug: Leflunomide|Drug: Azathioprine | RenJi Hospital|Changhai Hospital|Shanghai 10th People's Hospital|Shanghai Zhongshan Hospital|The First Affiliated Hospital with Nanjing Medical University|The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School|The First Affiliated Hospital of Soochow University|Zhejiang University|Second Affiliated Hospital, School of Medicine, Zhejiang University|First Affiliated Hospital of Wenzhou Medical Univeristy|Qilu Hospital|AnHui ShengLi Hospital|First Affiliated Hospital Bengbu Medical College|The First Affiliated Hospital of Anhui Medical University | 2010-03-01 | 2010-08-10 | |
NCT00504244 | Systemic Lupus Erythematosus | Drug: switch to Myfortic|Drug: continuation of azathioprine | Erasmus Medical Center|Novartis Pharmaceuticals | Phase 3 | 2007-07-01 | 2010-11-15 |
NCT02247258 | Crohn Disease|Recurrence|Azathioprine|Prevention | Drug: Azathioprine|Drug: Azathioprine in case of endoscopic recurrence|Procedure: Ileocolonoscopy|Procedure: Small bowel follow trough | Universitaire Ziekenhuizen Leuven|International organization for the study of inflammatory bowel disease (IOIBD) | Phase 2 | 2005-10-01 | 2015-05-28 |
NCT00626678 | Pemphigus Vulgaris | Drug: Azathioprine|Drug: Prednisone|Drug: Placebo | Tehran University of Medical Sciences | Phase 2 | 2008-01-01 | 2010-11-26 |
NCT00976690 | Crohn Disease | Drug: Azathioprine OR Mesalazine | Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives | Phase 3 | 2002-10-01 | 2011-08-30 |
NCT00946946 | Crohn's Disease | Drug: Azathioprine|Drug: Mesalazine|Drug: Azathioprine placebo|Drug: Mesalazine placebo | Dr. Falk Pharma GmbH | Phase 3 | 2002-02-01 | 2012-06-25 |
NCT02789397 | Granulomatous and Lymphocytic Interstitial Lung Disease | Drug: Rituximab (RTX) and Azathioprine (AZA)|Drug: Placebo Administration | Medical College of Wisconsin | Phase 2 | 2016-07-01 | 2016-06-07 |
NCT00204022 | Lupus Nephritis | Drug: Mycophenolate mofetil|Drug: Azathioprine | Frdric A. Houssiau, MD, PhD|Universit Catholique de Louvain | Phase 3 | 2001-02-01 | 2011-10-13 |
NCT01392833 | IgA Nephropathy|Chronic Kidney Disease | Drug: methylprednisolone|Drug: azathioprine|Drug: prednisone | A. Manzoni Hospital | Phase 3 | 1999-12-01 | 2011-07-12 |
NCT02425852 | Ulcerative Colitis | Drug: Azathioprine|Drug: Infliximab|Drug: Prednisolone|Drug: Hydrocortisone | Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives | Phase 4 | 2015-09-01 | 2015-04-23 |
NCT02900443 | Autoimmune Hepatitis | Drug: Mycophenolate mofetil|Drug: Azathioprine | Radboud University|Leiden University Medical Center | Phase 4 | 2017-01-01 | 2017-01-09 |
NCT02949349 | Lupus Nephritis | Drug: Mycophenolate mofetil|Drug: Azathioprine|Drug: Prednisolone | Genovate Biotechnology Co., Ltd., | Phase 2 | 2015-07-01 | 2017-03-01 |
NCT01697267 | Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis|Microscopic Polyangiitis|Wegener Granulomatosis | Biological: Rituximab|Drug: Azathioprine | Cambridge University Hospitals NHS Foundation Trust|Arthritis Research UK|Roche Pharma AG|Genentech, Inc.|University of Pennsylvania | Phase 3 | 2013-04-01 | 2017-02-21 |
NCT00755859 | IGA Nephropathy | Drug: steroids plus azathioprine|Drug: steroids | A. Manzoni Hospital | Phase 4 | 1998-05-01 | 2008-09-18 |
NCT00321906 | Delayed Graft Function|Acute Graft Rejection | Drug: azathioprine|Drug: sirolimus | University of Chicago|Astellas Pharma Inc|Loyola University|University of Florida|University of Pennsylvania|Baylor College of Medicine|Ochsner Health System|Columbia University|University of Wisconsin, Madison | Phase 4 | 2002-04-01 | 2016-09-19 |
NCT01112215 | Systemic Lupus Erythematosus | Drug: Azathioprine|Drug: Enteric-Coated Mycophenolate Sodium | Hospital Universitari Vall d'Hebron Research Institute | Phase 4 | 2009-12-01 | 2016-10-03 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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