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Metoclopramide HCl

盐酸甲氧氯普胺,Metoclopramide hydrochloride

MetoclopraMide hydrochloride is a selective dopamine D2 receptor antagonist which is used for the treatment of nausea and vomiting.

目录号
EY1736
EY1736
EY1736
纯度
99.39%
99.39%
99.39%
规格
50 mg
100 mg
500 mg
原价
220
430
520
售价
220
430
520
库存
现货
现货
现货
订购
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  • 生物活性

    Metoclopramide HCl is a selective dopamine D2 receptor antagonist, used for the treatment of nausea and vomiting.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Phedias Diamandis et. Al. Chemical genetics reveals a complex functional ground state of neural stem cells. Nature Chemical Biology, 3(5), 268-273 (2007).
    [2] B Y De Winter et. Al. Effect of different prokinetic agents and a novel enterokinetic agent on postoperative ileus in rats.Gut, 45(5), 713-718 (1999).

    分子式
    C14H23Cl2N3O2    		 分子量
    336.26    		 CAS号
    7232-21-5    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    60 mg/mL    		 Water
    60 mg/mL    		 Ethanol
    60 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02466984 Nausea|Vomiting Drug: metoclopramide intravenous University Hospital, Bordeaux Phase 3 2016-07-01 2017-02-22
    NCT02253524 Nausea|Vomiting|Vertigo Drug: Dimenhydrinate|Drug: Metoclopramide Pamukkale University Phase 4 2012-11-01 2014-09-27
    NCT00632606 Headache Drug: magnesium sulfate|Drug: metoclopramide Women and Infants Hospital of Rhode Island Phase 2|Phase 3 2008-08-01 2012-12-21
    NCT01631994 Gastric Transit Time Drug: metoclopramide Winthrop University Hospital 2011-09-01 2016-01-11
    NCT01289938 Drug Metabolism, Poor, CYP2D6-RELATED Drug: Diphenhydramine|Drug: Metoclopramide Matthias Schwab|University Hospital Tuebingen Phase 1 2009-07-01 2016-05-12
    NCT01522326 Acute Mountain Sickness|High Altitude Headache Drug: Ibuprofen|Drug: Metoclopramide Massachusetts General Hospital 2012-03-01 2016-09-12
    NCT01630109 Pill Capsule Endoscopy Completion Rates Drug: Metoclopramide|Drug: Placebo Genesys Regional Medical Center Phase 4 2012-12-01 2014-01-09
    NCT01011673 Headache Drug: Metoclopramide|Drug: Ketorolac Montefiore Medical Center Phase 4 2009-11-01 2012-12-05
    NCT03056352 Post-Traumatic Headache Drug: Metoclopramide|Drug: Diphenhydramine Montefiore Medical Center Early Phase 1 2017-03-01 2017-02-14
    NCT01596166 Probable Migraine|Migraine With Aura|Migraine Without Aura Drug: Ketorolac Tromethamine|Drug: Metoclopramide University of Alberta|Canadian Institutes of Health Research (CIHR) Phase 4 2012-02-01 2015-01-21
    NCT01093690 Cancer Drug: metoclopramide|Drug: placebo Mahidol University|Siriraj Hospital 2009-04-01 2010-11-04
    NCT02314351 Migraine Disorders Drug: Metoclopramide 10 mg|Drug: Placebo|Drug: Fentanyl Kocaeli University Phase 4 2014-12-01 2017-01-03
    NCT00845858 Gastroparesis|Diabetic Gastroparesis|Diabetes|Diabetes Mellitus|Delayed Gastric Emptying Drug: metoclopramide|Drug: Placebo Evoke Pharma Phase 2 2009-04-01 2014-06-17
    NCT01126034 Gastroesophageal Reflux Disease|Diabetic Gastroparesis Other: intervention letter University of Pennsylvania 2007-03-01 2015-12-03
    NCT02163434 Hyperemesis Gravidarum Drug: Gabapentin|Drug: Metoclopramide University at Buffalo|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Phase 3 2014-06-01 2015-08-02
    NCT02972502 Headache, Migraine Drug: Metoclopramide|Drug: Haloperidol|Other: Normal Saline|Drug: Diphenhydramine OhioHealth Phase 4 2014-02-01 2016-11-21
    NCT02939235 Unstable Angina Pectoris Drug: Crushed ticagrelor followed by morphine|Drug: Crushed ticagrelor, morphine,metoclopramide Collegium Medicum w Bydgoszczy Phase 4 2016-07-01 2016-12-20
    NCT02025725 Diabetic Gastroparesis Drug: Metoclopramide Nasal Spray|Drug: Placebo Nasal Spray Evoke Pharma Phase 3 2014-04-01 2016-08-08
    NCT02222220 Clozapine-induced Hypersalivation Drug: Metoclopramide|Drug: placebo Beersheva Mental Health Center|Tirat Carmel Mental Health Center Phase 3 2012-01-01 2014-08-20
    NCT00475306 Nausea|Extrapyramidal Symptoms Drug: metoclopramide 10 mg|Drug: Diphenhydramine 25 mg|Drug: Placebo|Drug: Metoclopramide 20 mg Montefiore Medical Center Phase 4 2007-05-01 2012-11-28
    NCT01165866 Gastroenteritis Drug: Treatment 1. Metoclopramide|Drug: Treatment 2 Ondansetron Hamad Medical Corporation Phase 4 2008-06-01 2010-10-25
    NCT02098915 Gastroschisis Drug: intravenous metoclopramide|Other: Placebo The Hospital for Sick Children|The Physicians' Services Incorporated Foundation Phase 3 2014-03-01 2017-01-18
    NCT01791400 Migraine Disorders Drug: metoclopramide, injection,20mg, one time|Drug: Sumatriptan, injection, 6 mg, one time Isfahan University of Medical Sciences Phase 2 2009-07-01 2013-02-13
    NCT01907633 Death, Sudden, Cardiac Drug: No intervention Janssen Research & Development, LLC Phase 4 2011-12-01 2015-05-18
    NCT02098499 Migraine Headaches|Nausea|Restlessness Drug: Haloperidol|Drug: Metoclopramide 10mg|Drug: Diphenhydramine United States Naval Medical Center, Portsmouth Phase 4 2013-06-01 2014-03-27

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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