Prednisolone是糖皮质素。
Prednisolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Kolls J, et al. Proc Soc Exp Biol Med, 1994, 205(3), 220-229.
分子式 C21H28O5 |
分子量 360.44 |
CAS号 50-24-8 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 72 mg/mL |
Water <1 mg/mL |
Ethanol 10 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT00632554 | Eosinophilic Pneumonia|Chronic Disease | Drug: prednisolone 0.5 mg/kg/day for three months|Drug: prednisolone 0.5 mg/kg/day for six months | Hamamatsu University | Phase 4 | 2008-06-01 | 2014-09-18 |
NCT00198523 | Eye Infections|Postoperative Complications | Drug: Prednisolone and Tobramycin|Drug: Prednisolone | Bausch & Lomb Incorporated | Phase 3 | 2005-07-01 | 2013-03-13 |
NCT00778596 | Chronic Hepatitis B | Drug: Prednisolone|Drug: Placebo priming | Yun-Fan Liaw|Chang Gung Memorial Hospital | Phase 4 | 2009-02-01 | 2012-05-24 |
NCT02299115 | Infantile Spasms | Drug: Prednisolone|Drug: Vigabatrin | The Hospital for Sick Children | Phase 3 | 2016-09-01 | 2016-04-16 |
NCT00971724 | Insulin Resistance|Hyperglycemia|Glucose Intolerance | Drug: Placebo|Drug: Prednisolone | Merck Sharp & Dohme Corp. | 2006-05-01 | 2015-05-21 | |
NCT01395251 | Rheumatoid Arthritis | Drug: Prednisolone | Rheumazentrum Ruhrgebiet | Phase 2|Phase 3 | 2012-02-01 | 2015-05-15 |
NCT00662298 | Asthma | Drug: prednisolone | Imperial College London|Royal Brompton & Harefield NHS Foundation Trust | Phase 4 | 2011-06-01 | 2015-03-25 |
NCT02935738 | Reproductive Sterility | Drug: Prednisolone treatment | Barz IVF Center for Infertility Treatment and Embryo Research|University of Baghdad | 2014-10-01 | 2016-10-14 | |
NCT00982072 | Minimal Change Disease | Drug: tacrolimus|Drug: prednisolone | Imperial College Healthcare NHS Trust | Phase 4 | 2009-12-01 | 2017-03-03 |
NCT02344888 | Infertility|Polycystic Ovarian Syndrome | Drug: Clomiphene citrate and Prednisolone|Drug: Clomiphene citrate | Mohamed Sayed Abdelhafez|Mansoura University | Phase 4 | 2015-02-01 | 2016-11-18 |
NCT00380133 | Pulmonary Disease, Chronic Obstructive | Drug: SB681323|Drug: Prednisolone|Drug: Placebo | GlaxoSmithKline | Phase 1 | 2005-06-01 | 2012-05-31 |
NCT01603030 | Eye Infection/Inflammation Other | Drug: moxifloxacin 0,5% + prednisolone 1%|Drug: moxifloxacin/prednisolone combination | Adapt Produtos Oftalmolgicos Ltda. | Phase 3 | 2012-06-01 | 2012-05-21 |
NCT02587117 | Oral Lichen Planus | Drug: lycopene|Drug: Prednisolone | B.P. Koirala Institute of Health Sciences | Phase 4 | 2013-02-01 | 2016-01-26 |
NCT00135122 | Headache | Drug: prednisolone | Sorlandet Hospital HF | Phase 3 | 2003-09-01 | 2008-09-11 |
NCT02252237 | Children Receiving Prednisone or Prednisolone or Methylprednisolone | Biological: Pharmacokinetic | Assistance Publique - Hpitaux de Paris | 2014-12-01 | 2016-12-15 | |
NCT01011621 | Dermatitis, Atopic|Dermatitis, Contact|Dermatitis, Seborrheic|Psoriasis | Drug: 0.5% prednisolone acetate cream|Drug: 0.1% betamethasone valerate cream | Mantecorp Industria Quimica e Farmaceutica Ltd. | Phase 3 | 2010-02-01 | 2009-11-10 |
NCT00810849 | Tuberculous Pericarditis | Drug: Prednisolone|Biological: Mycobacterium w immunotherapy | University of Cape Town|Population Health Research Institute | Phase 3 | 2008-12-01 | 2014-09-02 |
NCT00345046 | Glaucoma|Cataract | Drug: Pred Forte|Drug: EconoPred Plus|Drug: Prednisolone Acetate | Indiana University School of Medicine|Indiana University | Phase 4 | 2002-09-01 | 2015-06-02 |
NCT02229136 | Stomatitis|Oral Mucositis|Neoplasm of the Breast|Malignant Tumor of Breast | Drug: Miracle Mouthwash Plus Hydrocortisone|Drug: Prednisolone | US Oncology Research|Novartis Pharmaceuticals | Phase 2 | 2014-09-01 | 2016-09-15 |
NCT02949232 | Schizophrenia|Schizoaffective Disorder|Schizophreniform Disorder|Psychotic Disorder NOS | Drug: Prednisolone|Drug: Placebo Oral Tablet | UMC Utrecht | Phase 4 | 2014-07-01 | 2016-10-31 |
NCT01068392 | B-cell Lymphomas | Drug: Oxaliplatin, Prednisolone | Dong-A University Hospital|Samsung Medical Center|Asan Medical Center|Chung-Ang University|Kyungpook National University|Chonnam National University Hospital|Korea Cancer Center Hospital|Korea University | Phase 2 | 2009-10-01 | 2014-11-02 |
NCT01244334 | Cataracts|Corneal Edema|Retinal Structural Change, Deposit and Degeneration|Visual Acuity Reduced Transiently | Drug: Difluprednate ophthalmic emulsion 0.05%|Drug: Prednisolone acetate 1% | Edward J. Holland|Sirion Therapeutics, Inc.|Alcon Research|Parsons Medical Communications|Cincinnati Eye Institute Northern Kentucky | Phase 4 | 2009-03-01 | 2012-08-06 |
NCT02495662 | Renal Dialysis|Hemodynamics|Vascular Remodeling|Neointima | Drug: PEG-liposomal prednisolone sodium phosphate|Drug: Placebo | Leiden University Medical Center|HagaZiekenhuis|Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)|OLVG|Medical Center Haaglanden|Reinier de Graaf Groep|Spaarne Gasthuis|Alrijne Hospital|Tergooi Ziekenhuis | Phase 2 | 2015-11-01 | 2017-03-06 |
NCT01039103 | Acute Exacerbation of Remitting Relapsing Multiple Sclerosis|Clinically Isolated Syndrome | Drug: PEG-liposomal prednisolone sodium phosphate|Drug: Methylprednisolone | Galapagos NV | Phase 2 | 2009-12-01 | 2016-10-05 |
NCT00257933 | Asthma | Drug: Prednisolone high dose|Drug: Prednisolone lower dose | Children's Hospital of Philadelphia | Phase 4 | 2006-02-01 | 2010-12-23 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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