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Clomipramine HCl

盐酸氯米帕明

Clomipramine hydrochloride 是5-羟色胺转运体（SERT）、去甲肾上腺素转运体（NET）和多巴胺转运体（DAT）阻断剂，Ki分别为0.14，54和3 nM。

目录号
EY1728
EY1728
纯度
99.59%
99.59%
规格
100 mg
500 mg
原价
442
830
售价
442
830
库存
现货
现货
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  • 生物活性

    Clomipramine HCl is a hydrochloride salt of clomipramine which is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with Ki of 0.14, 54 and 3 nM, respectively.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Owens, M.J., et al. 1997. J. Pharmacol. Exp. Ther. 283: 1305-1322. PMID: 9400006
    [2] Ortiz, J. and Artigas, F. 1992. Br. J. Pharmacol. 105: 941-946. PMID: 1387022
    [3] McTavish, D. and Benfield, P. 1990. Drugs. 39: 136-153. PMID: 2178909

    分子式
    C19H24Cl2N2    		 分子量
    351.31    		 CAS号
    17321-77-6    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    70 mg/mL    		 Water
    70 mg/mL    		 Ethanol
    70 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02028598 Healthy Drug: Treatment 1|Drug: Treatment 2|Drug: Treatment 3 CTC Bio, Inc.|Symyoo Phase 1 2014-01-01 2014-09-12
    NCT00564564 Obsessive Compulsive Disorder Drug: Quetiapine|Drug: Clomipramine University of Sao Paulo|Conselho Nacional de Desenvolvimento Cientfico e Tecnolgico Phase 4 2006-01-01 2008-02-04
    NCT02571101 Premature Ejaculation Drug: CDFR0812-15/25mg|Drug: CDFR0812-15/50mg|Drug: Condencia|Drug: CDFR0812-Placebo|Drug: Condencia-Placebo CTC Bio, Inc.|Symyoo Phase 2 2015-11-01 2015-12-16
    NCT00913783 Depression Drug: Clomipramine Hydrochloride 25 mg Capsules (Geneva Pharmaceuticals)|Drug: Anafranil Clomipramine Hydrochloride 25 mg Capsules (Basel) Sandoz Phase 1 1992-11-01 2017-03-27
    NCT00913952 Depression Drug: Geneva 25 mg Clomipramine Hydrochloride Capsules Under Fasting Conditions|Drug: Geneva 25 mg Clomipramine Hydrochloride Capsules Under Fed Conditions|Drug: Basel (Anafranil) 25 mg Clomipramine Hydrochloride Capsules Under Fed Conditions Sandoz Phase 1 1994-04-01 2017-03-27
    NCT00004310 Obsessive-Compulsive Disorder Drug: Clomipramine National Center for Research Resources (NCRR)|Stanford University Phase 2 1999-10-01 2005-06-23
    NCT00466609 Obsessive Compulsive Disorder Drug: clomipramine and fluoxetine|Drug: quetiapine and fluoxetine|Drug: placebo and fluoxetine University of Sao Paulo|Fundao de Amparo Pesquisa do Estado de So Paulo|Conselho Nacional de Desenvolvimento Cientfico e Tecnolgico|Novartis Phase 4 2007-05-01 2010-05-12
    NCT01575158 Depression Drug: Citalopram|Drug: Clomipramine|Drug: placebo University of Aarhus|Danish University Antidepressant Group 1997-10-01 2012-04-10
    NCT01439984 Premature Ejaculation Drug: Clomipramine Symyoo Phase 3 2011-09-01 2012-10-01
    NCT01404871 Obsessive Compulsive Disorder Drug: clomipramine|Drug: escitalopram|Drug: duloxetine Sunnybrook Health Sciences Centre|Obsessive Compulsive Foundation|Centre for Addiction and Mental Health 2009-04-01 2013-01-30
    NCT00254735 Obsessive Compulsive Disorder Drug: quetiapine fumarate|Drug: SSRI/Clomipramine AstraZeneca Phase 3 2002-04-01 2007-12-14
    NCT01203202 Premature Ejaculation Drug: Clomipramine Symyoo Phase 2 2010-09-01 2012-10-01
    NCT00964886 Back Pain Behavioral: cognitive behavioral therapy|Drug: desipramine hydrochloride|Behavioral: cognitive behavioral therapy|Drug: benztropine mesylate 0.125 mg daily|Drug: desipramine hydrochloride VA Office of Research and Development|University of California, San Diego Phase 2 2010-01-01 2016-11-23
    NCT01896349 Treatment Resistant Depression Other: IPT+ antidepressant drugs|Drug: fluoxetine|Drug: sertraline|Drug: paroxetine|Drug: Citalopram|Drug: escitalopram|Drug: fluvoxamine|Drug: Venlafaxine|Drug: Duloxetine|Drug: Bupropion|Drug: Lithium|Drug: Risperidone|Drug: tranylcypromine|Drug: Imipramine|Drug: amitriptyline|Drug: Clomipramine|Drug: nortriptyline|Drug: trazodone|Drug: Mirtazapine|Drug: sulpiride Hospital de Clinicas de Porto Alegre 2013-04-01 2013-07-10
    NCT00018200 Back Pain|Sciatica Drug: Desipramine|Drug: Fluoxetine|Drug: Benztropine VA Office of Research and Development Phase 2 1999-04-01 2012-06-04
    NCT00944996 Major Depression Drug: SSRI; SNRI; TCA Tirat Carmel Mental Health Center|University of Michigan|Ariel University|The Nazareth Hospital, Israel 2009-06-01 2012-07-25
    NCT01148316 Obsessive-Compulsive Disorder Drug: fluoxetine|Behavioral: Group cognitive-behavioral therapy Roseli Shavitt|University of Pernambuco|University of Sao Paulo 2010-08-01 2014-10-23
    NCT02431845 Obsessive-Compulsive Disorder Drug: SSRIs Severance Hospital 2013-01-01 2015-11-16
    NCT00704860 Major Depression Other: Open label pharmacotherapy University of Ottawa Phase 4 2005-02-01 2011-01-18
    NCT01944657 1. Major Depressive Disorder. Device: Supplemental TMS|Drug: Standard Medication Monotherapy Sheppard Pratt Health System|Central Michigan University 2013-09-01 2014-11-03
    NCT00074815 Obsessive-Compulsive Disorder Drug: Serotonin reuptake inhibitors management|Behavioral: Cognitive behavioral therapy by a psychologist|Behavioral: Instructional cognitive behavioral therapy by a psychiatrist Duke University|National Institute of Mental Health (NIMH) Phase 3 2003-09-01 2014-07-23
    NCT02374567 Dementia|Depression|Schizophrenia|Psychosomatic Disorders|Anxiety Disorders Drug: Phenobarbital|Drug: Phenytoin|Drug: Carbamazepine|Drug: Oxcarbazepine|Drug: Valproic Acid|Drug: Lamotrigine|Drug: Topiramate|Drug: Gabapentin|Drug: Levetiracetam|Drug: Pregabalin|Drug: Lacosamide|Drug: Clonazepam|Drug: Biperiden|Drug: Levomepromazine|Drug: Fluphenazine|Drug: Perphenazine|Drug: Perazine|Drug: Thioridazine|Drug: Haloperidol|Drug: Melperone|Drug: Pipamperone|Drug: Bromperidol|Drug: Benperidol|Drug: Sertindole|Drug: Ziprasidone|Drug: Flupentixol|Drug: Chlorprothixene|Drug: Zuclopenthixol|Drug: Fluspirilene|Drug: Pimozide|Drug: Clozapine|Drug: Olanzapine|Drug: Quetiapine|Drug: Sulpiride|Drug: Tiapride|Drug: Amisulpride|Drug: Prothipendyl|Drug: Risperidone|Drug: Aripiprazole|Drug: Paliperidone|Drug: Diazepam|Drug: Oxazepam|Drug: Lorazepam|Drug: Bromazepam|Drug: Clobazam|Drug: Alprazolam|Drug: Hydroxyzine|Drug: Buspirone|Drug: Chloral Hydrate|Drug: Flurazepam|Drug: Nitrazepam|Drug: Triazolam|Drug: Lormetazepam|Drug: Temazepam|Drug: Midazolam|Drug: Brotizolam|Drug: Zopiclone|Drug: Zolpidem|Drug: Zaleplon|Drug: Melatonin|Drug: Clomethiazole|Drug: Diphenhydramine|Drug: Promethazine|Drug: Imipramine|Drug: Clomipramine|Drug: Opipramol|Drug: Trimipramine|Drug: Amitriptyline|Drug: Nortriptyline|Drug: Doxepin|Drug: Maprotiline|Drug: Amitriptyline oxide|Drug: Fluoxetine|Drug: Citalopram|Drug: Paroxetine|Drug: Sertraline|Drug: Fluvoxamine|Drug: Escitalopram|Drug: Tranylcypromine|Drug: Moclobemide|Drug: Mianserin|Drug: Trazodone|Drug: Mirtazapine|Drug: Bupropion|Drug: Venlafaxine|Drug: Reboxetine|Drug: Duloxetine|Drug: Agomelatine|Drug: Pyritinol|Drug: Piracetam|Drug: Donepezil|Drug: Rivastigmine|Drug: Galantamine|Drug: Memantine|Drug: Nicergoline|Drug: Acamprosate|Drug: Lithium Hannover Medical School Phase 3 2015-01-01 2017-02-23
    NCT01305707 Depression Device: C-ECT|Drug: PHARMACOTHERAPY Hospital Universitari de Bellvitge Phase 4 2009-07-01 2015-08-28

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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