Loxapine Succinate是一种D2DR和D4DR抑制剂,血清素激活受体拮抗剂,也是一种苯氧氮平类抗精神病药。
Loxapine Succinate is a D2DR and D4DR inhibitor, serotonergic receptor antagonist and also a dibenzoxazepine anti-psychotic agent.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Singh AN, et al. J Psychiatry Neurosci, 1996, 21(1), 29-35.
分子式 C18H18ClN3O.C4H6O4 |
分子量 445.9 |
CAS号 27833-64-3 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 200 mM |
Water <1 mg/mL |
Ethanol 5 mM |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT02525991 | Agitation | Device: Staccato Delivery System Loxapine (ADASUVE) | Ferrer Internacional S.A. | Phase 4 | 2015-11-01 | 2015-08-17 |
NCT02820519 | Neuropathic Pain | Drug: Loxapine | University of Witten/Herdecke | Phase 2 | 2016-06-01 | 2017-02-06 |
NCT01854710 | Healthy Volunteers | Drug: ADASUVE 10 mg 2 doses 2 hours apart|Drug: Oral moxifloxacin 400 mg|Drug: Staccato Placebo 2 doses 2 hours apart|Drug: Placebo (for moxifloxacin) | Alexza Pharmaceuticals, Inc. | Phase 1 | 2013-05-01 | 2013-07-11 |
NCT00890175 | Asthma | Drug: Inhaled loxapine @ 0 & 10 h|Drug: Inhaled placebo @ 2 & 10 hours | Alexza Pharmaceuticals, Inc. | Phase 1 | 2009-05-01 | 2017-03-13 |
NCT00648778 | Healthy | Drug: Loxapine Succinate Capsules 25 mg|Drug: Loxitane Capsules 25 mg | Mylan Pharmaceuticals | Phase 1 | 2003-01-01 | 2008-03-31 |
NCT02184767 | BiPolar | Drug: ADASUVE | Teva Branded Pharmaceutical Products, R&D Inc.|Teva Pharmaceutical Industries | Phase 1 | 2014-07-01 | 2016-02-26 |
NCT00873769 | Smoking, Cigarette | Drug: Inhaled Loxapine 10 mg | Alexza Pharmaceuticals, Inc. | Phase 1 | 2009-04-01 | 2017-03-13 |
NCT00889837 | Chronic Obstructive Pulmonary Disease | Drug: Inhaled Loxapine|Drug: Inhaled Placebo | Alexza Pharmaceuticals, Inc. | Phase 1 | 2009-06-01 | 2017-03-13 |
NCT01877642 | Healthy Volunteers | Drug: ADASUVE 10 mg|Drug: Lorazepam 2 mg IM|Drug: Staccato Placebo|Drug: Placebo IM | Alexza Pharmaceuticals, Inc. | Phase 1 | 2013-06-01 | 2013-07-30 |
NCT00290082 | Acute Agitated Patients | Drug: loxapine, midazolam|Biological: blood sample|Other: patient monitoring|Drug: Loxapine|Drug: Midazolam | University Hospital, Rouen | Phase 3 | 2005-12-01 | 2015-03-10 |
NCT00628589 | Schizophrenic Patients With Acute Agitation | Drug: loxapine|Drug: loxapine|Drug: placebo | Alexza Pharmaceuticals, Inc. | Phase 3 | 2008-02-01 | 2008-06-10 |
NCT00721955 | Bipolar I Disorder | Drug: loxapine|Drug: loxapine|Drug: placebo | Alexza Pharmaceuticals, Inc. | Phase 3 | 2008-07-01 | 2008-10-22 |
NCT00555412 | Volunteers on Chronic, Stable Antipsychotic Regimens | Drug: A - 10 mg loxapine q 4 h x 3 (30 mg total)|Drug: B - 10 mg x 1, 5 mg x 2 loxapine q 4 h (20 mg total)|Drug: C - 5 mg loxapine q 4 h x 3 (15 mg total)|Drug: D - inhaled placebo q 4 h x 3 | Alexza Pharmaceuticals, Inc.|Atlanta Center for Medical Research | Phase 1 | 2007-10-01 | 2017-03-13 |
NCT01193816 | Restlessness | Drug: loxapine|Drug: Placebo | Assistance Publique - Hpitaux de Paris | Phase 4 | 2011-05-01 | 2014-07-17 |
NCT00874237 | Healthy | Drug: 1 (Staccato Loxapine)|Drug: 2 (Moxifloxacin)|Drug: 3 (Placebo) | Alexza Pharmaceuticals, Inc. | Phase 1 | 2009-04-01 | 2009-06-18 |
NCT00444028 | Schizophrenia | Drug: Loxapine thermal aerosol | Alexza Pharmaceuticals, Inc. | Phase 1 | 2005-10-01 | 2007-03-05 |
NCT00489476 | Migraine | Drug: Loxapine Thermal Aerosol | Alexza Pharmaceuticals, Inc. | Phase 2 | 2007-06-01 | 2008-04-09 |
NCT00122733 | Respiratory Insufficiency|Psychomotor Agitation | Drug: loxapine | Assistance Publique - Hpitaux de Paris | 2005-12-01 | 2007-07-20 | |
NCT00369577 | Schizophrenia | Drug: Loxapine thermal aerosol | Alexza Pharmaceuticals, Inc. | Phase 2 | 2006-08-01 | 2007-01-18 |
NCT00825500 | Migraine Headache | Drug: High dose|Drug: Low dose|Drug: Placebo | Alexza Pharmaceuticals, Inc. | Phase 2 | 2009-01-01 | 2017-01-30 |
NCT00789360 | Healthy | Drug: Placebo -- Active|Drug: Active -- Placebo | Alexza Pharmaceuticals, Inc. | Phase 1 | 2008-11-01 | 2009-05-04 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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