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Loxapine Succinate

丁二酸洛沙平

Loxapine Succinate是一种D2DR和D4DR抑制剂,血清素激活受体拮抗剂,也是一种苯氧氮平类抗精神病药。

目录号
EY1723
EY1723
纯度
99.49%
99.49%
规格
100 mg
500 mg
原价
690
2300
售价
690
2300
库存
现货
现货
订购
订购
订购
订购
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  • 生物活性

    Loxapine Succinate is a D2DR and D4DR inhibitor, serotonergic receptor antagonist and also a dibenzoxazepine anti-psychotic agent.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Singh AN, et al. J Psychiatry Neurosci, 1996, 21(1), 29-35.

    分子式
    C18H18ClN3O.C4H6O4
    分子量
    445.9
    CAS号
    27833-64-3
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    200 mM
    Water
    <1 mg/mL
    Ethanol
    5 mM

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02525991 Agitation Device: Staccato Delivery System Loxapine (ADASUVE) Ferrer Internacional S.A. Phase 4 2015-11-01 2015-08-17
    NCT02820519 Neuropathic Pain Drug: Loxapine University of Witten/Herdecke Phase 2 2016-06-01 2017-02-06
    NCT01854710 Healthy Volunteers Drug: ADASUVE 10 mg 2 doses 2 hours apart|Drug: Oral moxifloxacin 400 mg|Drug: Staccato Placebo 2 doses 2 hours apart|Drug: Placebo (for moxifloxacin) Alexza Pharmaceuticals, Inc. Phase 1 2013-05-01 2013-07-11
    NCT00890175 Asthma Drug: Inhaled loxapine @ 0 & 10 h|Drug: Inhaled placebo @ 2 & 10 hours Alexza Pharmaceuticals, Inc. Phase 1 2009-05-01 2017-03-13
    NCT00648778 Healthy Drug: Loxapine Succinate Capsules 25 mg|Drug: Loxitane Capsules 25 mg Mylan Pharmaceuticals Phase 1 2003-01-01 2008-03-31
    NCT02184767 BiPolar Drug: ADASUVE Teva Branded Pharmaceutical Products, R&D Inc.|Teva Pharmaceutical Industries Phase 1 2014-07-01 2016-02-26
    NCT00873769 Smoking, Cigarette Drug: Inhaled Loxapine 10 mg Alexza Pharmaceuticals, Inc. Phase 1 2009-04-01 2017-03-13
    NCT00889837 Chronic Obstructive Pulmonary Disease Drug: Inhaled Loxapine|Drug: Inhaled Placebo Alexza Pharmaceuticals, Inc. Phase 1 2009-06-01 2017-03-13
    NCT01877642 Healthy Volunteers Drug: ADASUVE 10 mg|Drug: Lorazepam 2 mg IM|Drug: Staccato Placebo|Drug: Placebo IM Alexza Pharmaceuticals, Inc. Phase 1 2013-06-01 2013-07-30
    NCT00290082 Acute Agitated Patients Drug: loxapine, midazolam|Biological: blood sample|Other: patient monitoring|Drug: Loxapine|Drug: Midazolam University Hospital, Rouen Phase 3 2005-12-01 2015-03-10
    NCT00628589 Schizophrenic Patients With Acute Agitation Drug: loxapine|Drug: loxapine|Drug: placebo Alexza Pharmaceuticals, Inc. Phase 3 2008-02-01 2008-06-10
    NCT00721955 Bipolar I Disorder Drug: loxapine|Drug: loxapine|Drug: placebo Alexza Pharmaceuticals, Inc. Phase 3 2008-07-01 2008-10-22
    NCT00555412 Volunteers on Chronic, Stable Antipsychotic Regimens Drug: A - 10 mg loxapine q 4 h x 3 (30 mg total)|Drug: B - 10 mg x 1, 5 mg x 2 loxapine q 4 h (20 mg total)|Drug: C - 5 mg loxapine q 4 h x 3 (15 mg total)|Drug: D - inhaled placebo q 4 h x 3 Alexza Pharmaceuticals, Inc.|Atlanta Center for Medical Research Phase 1 2007-10-01 2017-03-13
    NCT01193816 Restlessness Drug: loxapine|Drug: Placebo Assistance Publique - Hpitaux de Paris Phase 4 2011-05-01 2014-07-17
    NCT00874237 Healthy Drug: 1 (Staccato Loxapine)|Drug: 2 (Moxifloxacin)|Drug: 3 (Placebo) Alexza Pharmaceuticals, Inc. Phase 1 2009-04-01 2009-06-18
    NCT00444028 Schizophrenia Drug: Loxapine thermal aerosol Alexza Pharmaceuticals, Inc. Phase 1 2005-10-01 2007-03-05
    NCT00489476 Migraine Drug: Loxapine Thermal Aerosol Alexza Pharmaceuticals, Inc. Phase 2 2007-06-01 2008-04-09
    NCT00122733 Respiratory Insufficiency|Psychomotor Agitation Drug: loxapine Assistance Publique - Hpitaux de Paris 2005-12-01 2007-07-20
    NCT00369577 Schizophrenia Drug: Loxapine thermal aerosol Alexza Pharmaceuticals, Inc. Phase 2 2006-08-01 2007-01-18
    NCT00825500 Migraine Headache Drug: High dose|Drug: Low dose|Drug: Placebo Alexza Pharmaceuticals, Inc. Phase 2 2009-01-01 2017-01-30
    NCT00789360 Healthy Drug: Placebo -- Active|Drug: Active -- Placebo Alexza Pharmaceuticals, Inc. Phase 1 2008-11-01 2009-05-04

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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