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Adenosine

腺苷

Adenosine是一种核苷，由腺嘌呤，通过β-N9-糖苷键，与核糖分子（呋喃核糖的）部分连接组成。

目录号
EY1702
EY1702
EY1702
纯度
99.32%
99.32%
99.32%
规格
500 mg
1 g
5 g
原价
336
455
642
售价
336
455
642
库存
现货
现货
现货
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  • 生物活性

    Adenosine is a nucleoside composed of a molecule of adenine attached to a ribose sugar molecule (ribofuranose) moiety via a β-N9-glycosidic bond.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Daniela Valletta et. Al. Carcinogenesis, 35(6), 1407-1415 (2014).
    [2] Hillary Johnston-Cox et. Al. PLoS ONE, 9(6), e98775 (2014).
    [3] Phedias Diamandis et. Al. Nature Chemical Biology, 3(5), 268-273 (2007).

    分子式
    C10H13N5O4    		 分子量
    267.24    		 CAS号
    58-61-7    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    12 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00881686 Heart Defects, Congenital|Cardiac Surgical Procedures|Myocardial Reperfusion Injury|Adenosine Drug: adenosine Xijing Hospital Phase 1|Phase 2 2008-06-01 2009-04-14
    NCT01690884 Coronary Artery Disease Drug: Adenosine Vanderbilt University|Vanderbilt University Medical Center Phase 1 2012-08-01 2017-01-16
    NCT02462941 Sinus Bradycardia|Atrioventricular Block Drug: Adenosine|Procedure: Cardiac catheterization Columbia University Phase 1 2015-07-01 2016-07-28
    NCT01932112 Atrial Fibrillation|Persistent Common Pulmonary Vein Drug: Adenosine arm Seoul St. Mary's Hospital Phase 3 2012-11-01 2016-03-14
    NCT00179010 Ischemia Drug: Adenosine|Drug: Adenosine Mono Phosphate (AMP) Vanderbilt University 2003-10-01 2015-02-02
    NCT01590875 Atrial Fibrillation Drug: Adenosine arm Medical College of Wisconsin 2012-05-01 2016-09-12
    NCT01610921 Asthma Other: Bronchial provocation test University Medical Center Groningen|Chiesi Farmaceutici S.p.A. 2012-02-01 2014-07-10
    NCT01123525 Angina Pectoris Drug: Adenosine University Hospital of North Norway Phase 1|Phase 2 2010-04-01 2011-09-29
    NCT02681913 Pathological Processes|Cardiomyopathies Drug: Adenosine Amphia Hospital Phase 2 2016-02-01 2016-02-10
    NCT00612521 Coronary Artery Stenosis|Coronary Artery Disease Drug: Adenosine Ottawa Heart Institute Research Corporation Phase 3 2007-08-01 2012-08-28
    NCT00864591 Coronary Artery Disease|Cardiac Perfusion Procedure: SPECT Imaging|Procedure: Stress Adenosine CMR Sheba Medical Center 2009-04-01 2009-03-17
    NCT02350439 Coronary Artery Disease Drug: Adenosine infusion at 200g/Kg/min University of Patras Phase 3 2015-01-01 2017-01-08
    NCT01370265 Coronary Artery Disease Drug: Regadenoson|Drug: Adenosine|Drug: N-13 ammonia Mayo Clinic|Astellas Pharma Inc 2011-02-01 2013-09-03
    NCT00205166 Coronary Artery Disease Procedure: Cardiac SPECT imaging Rest and Stress|Drug: Caffeine|Drug: Caffeine University of Wisconsin, Madison|Astellas Pharma US, Inc. 1999-06-01 2012-10-25
    NCT01161121 Coronary Artery Disease Drug: adenosine|Drug: regadenoson|Drug: Adenosine St. Louis University|University of Florida|Astellas Pharma US, Inc. Phase 1 2010-07-01 2012-11-13
    NCT00208312 Coronary Artery Disease Drug: Regadenoson|Drug: Adenosine Gilead Sciences|Astellas Pharma US, Inc. Phase 3 2004-04-01 2009-11-24
    NCT00208299 Coronary Artery Disease Drug: Regadenoson|Drug: Adenosine Gilead Sciences|Astellas Pharma US, Inc. Phase 3 2003-10-01 2009-11-24
    NCT03032965 Atrial Fibrillation Drug: Adenosine|Drug: Isoproterenol University of Michigan Phase 2 2011-10-01 2017-01-23
    NCT00580905 Inflammation Drug: Adenosine|Drug: Sodium Nitroprusside|Drug: Adenosine Vanderbilt University|Vanderbilt University Medical Center Phase 1 2007-06-01 2017-02-17
    NCT02509546 Recurrent Adult Acute Myeloid Leukemia|Relapsed Adult Acute Myeloid Leukemia|Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome|Acute Myeloid Leukemia Arising From Previous Myeloproliferative Disorder Other: Laboratory Biomarker Analysis|Other: Pharmacological Study|Drug: 8-chloro-adenosine City of Hope Medical Center|National Cancer Institute (NCI) Phase 1|Phase 2 2015-09-01 2016-11-08
    NCT01495481 Supraventricular Tachycardia Drug: Dexmedetomidine|Drug: Adenosine University of Pittsburgh 2012-01-01 2017-02-07
    NCT01672346 Paroxysmal Atrial Fibrillation Procedure: PVAI followed by adenosine provocation Texas Cardiac Arrhythmia Research Foundation|California Pacific Medical Center Phase 3 2013-05-01 2015-05-19
    NCT00714103 Leukemia|Chronic Lymphocytic Leukemia Drug: 8-Chloro-Adenosine M.D. Anderson Cancer Center|National Cancer Institute (NCI)|FDA Office of Orphan Products Development Phase 1 2008-06-01 2016-10-12

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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