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D-Cycloserine

D-环丝氨酸,RO-1-9213,Seromycin

D-Cycloserine是D型丙氨酸类似物。

目录号
EY1691
EY1691
纯度
99.62%
99.62%
规格
100 mg
500 mg
原价
402
683
售价
402
683
库存
现货
现货
订购
订购
订购
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  • 生物活性

    D-Cycloserine is an analog of the amino acid D-alanine.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Parnas AS, et al. Neurobiol Learn Mem,?005, 83(3), 224-231.

    分子式
    C3H6N2O2    		 分子量
    102.09    		 CAS号
    68-41-7    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    <1 mg/mL    		 Water
    20 mg/mL    		 Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00455702 Schizophrenia Drug: d-cycloserine Massachusetts General Hospital Phase 4 2004-07-01 2014-07-14
    NCT00964041 Schizophrenia Drug: D-cycloserine|Drug: Placebo Massachusetts General Hospital|National Institute of Mental Health (NIMH) Phase 4 2009-07-01 2013-11-19
    NCT00742079 Schizophrenia Drug: D-cycloserine|Behavioral: Cognitive Behavioral Therapy Massachusetts General Hospital|National Institute of Mental Health (NIMH) Phase 4 2006-09-01 2014-09-03
    NCT02772211 Treatment Resistant Depression Drug: Ketamine|Drug: D-cycloserine|Drug: Placebo Sheba Medical Center|Teva Pharmaceuticals USA|Tel Aviv University Phase 4 2016-06-01 2016-05-11
    NCT01399866 Smoking Cessation Drug: D-cycloserine|Drug: Placebo Massachusetts General Hospital Phase 3 2011-05-01 2016-03-14
    NCT01362309 Alcohol Use Disorders. Drug: d-cycloserine. University of Georgia|National Institute on Alcohol Abuse and Alcoholism (NIAAA)|Boston University|Brown University 2010-11-01 2014-02-14
    NCT00408031 Major Depressive Disorder Drug: D-cycloserine Herzog Hospital|National Alliance for Research on Schizophrenia and Depression Phase 2 2007-01-01 2012-08-02
    NCT00125528 Low Back Pain|Pain Drug: D-cycloserine|Drug: placebo Thomas J. Schnitzer|Northwestern University Phase 2 2012-07-01 2016-12-16
    NCT01086475 Autistic Disorder|Asperger's Disorder|Pervasive Developmental Disorder NOS Drug: D-cycloserine|Drug: Placebo Indiana University|United States Department of Defense Phase 3 2010-03-01 2016-03-15
    NCT01157429 Posttraumatic Stress Disorder|PTSD Drug: D-cycloserine|Drug: Placebo pill Tulane University School of Medicine|National Alliance for Research on Schizophrenia and Depression Phase 2 2010-06-01 2012-06-29
    NCT00633984 Social Anxiety Disorder Behavioral: Cognitive Behavioral Group Therapy (CBGT)|Drug: D-Cycloserine|Drug: Placebo Massachusetts General Hospital|Boston University|Southern Methodist University|National Institutes of Health (NIH)|National Institute of Mental Health (NIMH) Phase 4 2007-03-01 2014-04-14
    NCT01157416 Posttraumatic Stress Disorders|PTSD Drug: D-cycloserine|Drug: Placebo pill Tulane University School of Medicine|National Institute of Mental Health (NIMH) Phase 2 2010-06-01 2012-06-29
    NCT02304432 Schizophrenia|Bipolar Disorder Drug: D-cycloserine|Drug: placebo Mclean Hospital|University of Minnesota - Clinical and Translational Science Institute Early Phase 1 2015-01-01 2017-01-30
    NCT01649895 Obsessive-compulsive Disorder Drug: D-Cycloserine|Drug: Placebo Christian Rck|The Swedish Research Council|Knigska|Stockholm County Council, Sweden|Karolinska Institutet Phase 4 2012-08-01 2016-12-09
    NCT02983734 Gulf War Illness Drug: D-cycloserine|Drug: Placebos Boston University Charles River Campus Phase 2 2015-10-01 2017-03-06
    NCT00842309 Body Dysmorphic Disorder Drug: d-cycloserine|Drug: Placebo Massachusetts General Hospital Early Phase 1 2008-11-01 2016-05-27
    NCT01102803 Phobic Disorders Behavioral: Individual Cognitive Behavioral Therapy (CBT)|Drug: D-Cycloserine|Drug: Placebo Southern Methodist University Phase 3 2010-04-01 2013-01-18
    NCT01680107 Panic Disorder Drug: d-cycloserine|Drug: placebo|Behavioral: cognitive-behaviour therapy University of Oxford|Medical Research Council Phase 3 2012-10-01 2015-12-02
    NCT01361633 Treatment|Placebo Drug: d-cycloserine|Drug: Sugar Pill Hartford Hospital Phase 2 2008-01-01 2012-05-18
    NCT00000371 Schizophrenia Drug: D-cycloserine|Drug: Placebo Massachusetts General Hospital Phase 3 1996-08-01 2014-09-03
    NCT02933684 Social Anxiety Disorder Drug: Seromycin|Behavioral: Virtual Reality Exposure Therapy|Drug: Placebo Georgia State University|Emory University Phase 2 2018-01-01 2017-02-27
    NCT01343862 Traumatic Brain Injury Drug: D-cycloserine|Drug: placebo Hadassah Medical Organization Phase 2 2011-08-01 2011-04-27
    NCT01172873 Obsessive Compulsive Disorder Drug: D-cycloserine|Behavioral: Exposure and Response Prevention (EX/RP) New York State Psychiatric Institute|Emory University 2008-09-01 2014-08-15
    NCT01928823 Agoraphobia Behavioral: CBT|Drug: D-Cycloserine Charite University, Berlin, Germany|German Federal Ministry of Education and Research Phase 2 2011-11-01 2014-05-16
    NCT02066792 Social Anxiety Disorder Drug: D-Cycloserine|Drug: Placebo|Behavioral: Cognitive Behavioral Therapy University of Texas at Austin|Rush University Medical Center|Boston University|Southern Methodist University Early Phase 1 2014-04-01 2017-02-24

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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