Home > Cytochromes P450 (CYPs) & > Clarithromycin

Clarithromycin

克拉霉素,甲基红霉素,A-56268,A 56268,A56268

Clarithromycin 是一种大环内酯类抗生素,是CYP3A4抑制剂。

目录号
EY1690
EY1690
EY1690
纯度
99.22%
99.22%
99.22%
规格
100 mg
200 mg
500 mg
原价
542
786
998
售价
542
786
998
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Clarithromycin is a macrolide antibiotic and a CYP3A4 inhibitor, used to treat a number of bacterial infections.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Kikuchi T, et al. J Antimicrob Chemother, 2002, 49(5), 745-755.

    分子式
    C38H69NO13
    分子量
    747.95
    CAS号
    81103-11-9
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    18 mg/mL
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01075204 Respiratory Tract Infection Drug: clarithromycin modified release 500 mg Abbott|Eilaf CRO 2011-01-01 2013-02-06
    NCT02052336 Healthy Drug: CJ-12420 200mg + Clarithromycin 500mg|Drug: CJ-12420 200mg|Drug: Clarithromycin 500mg CJ HealthCare Corporation Phase 1 2013-10-01 2016-12-13
    NCT01223690 Sepsis|Severe Sepsis|Septic Shock Drug: Clarithromycin|Drug: Dextrose 5% University of Athens Phase 3 2007-07-01 2011-08-03
    NCT00269386 Crohn's Disease Drug: Clarithromycin|Drug: Placebo Royal Liverpool University Hospital|Abbott Phase 3 2000-04-01 2009-01-06
    NCT01521364 Multidrug-resistant Tuberculosis|Extensively Drug-resistant Tuberculosis Drug: Addition of different doses of clarithromycin. University Medical Center Groningen Phase 4 2011-12-01 2013-05-27
    NCT01146600 Hypersomnia|Idiopathic Hypersomnia|Narcolepsy Drug: Clarithromycin followed by placebo|Drug: Placebo then Clarithromycin Lynn Marie Trotti|Emory University Phase 2 2010-07-01 2014-08-25
    NCT01421706 Healthy Drug: Sibutramine-clopidogrel|Drug: sibutramine-Clarithromycin Inje University Phase 1 2008-07-01 2012-09-16
    NCT02080780 CLARITHROMYCIN/DILTIAZEM [VA Drug Interaction] Drug: Clarithromycin XL|Drug: 2% Diltiazem Ventrus Biosciences, Inc|TKL Research, Inc. Phase 1 2013-09-01 2014-03-07
    NCT02416570 Cachexia|Lung Cancer Drug: Clarithromycin|Drug: Placebo University of Nottingham|Roy Castle Lung Cancer Foundation Phase 2 2015-04-01 2016-09-15
    NCT02573935 Multiple Myeloma Drug: Clarithromycin|Drug: Placebo|Drug: VCD induction therapy Henrik Gregersen|Danish Myeloma Study Group|Aalborg Universitetshospital Phase 2 2015-01-01 2016-09-19
    NCT01851954 Very Low Birth Weight Infant|Ureaplasma/Mycoplasma Positive Drug: Clarithromycin Seoul National University Hospital Phase 2 2013-02-01 2014-11-17
    NCT03043989 Prostate Cancer Drug: Docetaxel|Drug: Cabazitaxel|Drug: Clarithromycin Sidney Kimmel Comprehensive Cancer Center Phase 1 2017-02-15 2017-02-13
    NCT00648830 Healthy Procedure: Clarithromycin|Drug: Clarithromycin Mylan Pharmaceuticals|Genpharm ULC Phase 1 2004-05-01 2008-03-31
    NCT02807051 Drug Interaction Study Drug: Pacritinib|Drug: Clarithromycin|Drug: Pacritinib and Clarithromycin CTI BioPharma|Covance Phase 1 2014-09-01 2016-06-20
    NCT00719420 Helicobacter Pylori Infection Drug: Clarithromycin, Metronidazole, Amoxicillin (+Omeprazole)|Drug: Clarithromycin, Amoxicillin, Omeprazole University of North Texas Health Science Center|Universidad del Valle, Colombia|Vanderbilt University Phase 3 2006-04-01 2008-07-18
    NCT01516606 Lymphoma Drug: clarithromycin, oral, high dose Andres J. M. Ferreri|IRCCS San Raffaele Phase 2 2012-01-01 2012-01-19
    NCT01385683 Healthy Drug: Dabigatran then dabigatran and clarithromycin|Drug: Clarithromycin and dabigatran then dabigatran Centre Hospitalier Universitaire de Saint Etienne|Groupe de Recherche sur la Thrombose Phase 1 2011-06-01 2012-03-21
    NCT02998437 Drug Interaction Potentiation Drug: Ilaprazole 10mg|Drug: Clarithromycin 500mg|Drug: Amoxicillin 500 Mg Il-Yang Pharm. Co., Ltd.|Severance Hospital Phase 1 2016-12-01 2017-01-24
    NCT02774902 Healthy Volunteers Drug: TAK-438|Drug: Clarithromycin Takeda Phase 1 2010-08-01 2016-05-13
    NCT02829983 Aggressive Periodontitis Drug: Clarithromycin|Drug: Placebo|Other: One-stage full-mouth ultrasonic debridement (FMUD) Universidade Estadual Paulista Jlio de Mesquita Filho|Coordenao de Aperfeioamento de Pessoal de Nvel Superior. 2014-03-01 2016-07-12
    NCT00297674 Sepsis|Ventilator Associated Pneumonia Drug: Intravenous Clarithromycin University of Athens Phase 4 2004-06-01 2006-02-27
    NCT00461084 Lymphoma Drug: BIAXIN (CLARITHROMYCIN)|Drug: Biaxin (clarithromycin) Memorial Sloan Kettering Cancer Center Phase 2 2007-04-01 2014-09-17
    NCT02286635 Healthy Volunteers Drug: Deflazacort and rifampin|Drug: Deflazacort and Clarithromycin Marathon Pharmaceuticals, LLC Phase 1 2014-11-01 2016-01-06
    NCT00121550 Heart Disease|Cardiovascular Disease Drug: clarithromycin Copenhagen Trial Unit, Center for Clinical Intervention Research|Danish Heart Foundation|Copenhagen Hospital Corporation|The Danish Medical Research Council|The 1991 Pharmacy Foundation|Abbott Phase 3 1999-10-01 2016-08-10

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

  • 相关化合物库

  • 使用AMQUAR产品发表文献后请联系我们

相关推荐

X
  • 联系人 :
  • 收件地址 :
  • 电话号码 :
  • 单位名称 :
  • 产品货号 :
  • 产品规格 :
  • 发票抬头以及单位税号 :