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Febuxostat

非布索坦,非布司他,TMX67,TMX-67,TEI-6720,Uloric,TMX 67,TEI 6720,TEI6720,FBX

Febuxostat是选择性黄嘌呤氧化酶(XO)抑制剂,Ki为0.6 nM。

目录号
EY1669
EY1669
EY1669
EY1669
EY1669
纯度
99.36%
99.36%
99.36%
99.36%
99.36%
规格
1 mg
5 mg
25 mg
50 mg
100 mg
原价
120
300
500
1210
2030
售价
120
300
500
1210
2030
库存
现货
现货
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Febuxostat is a selective xanthine oxidase inhibitor with Ki of 0.6 nM.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Takano Y, et al. Life Sci, 2005, 76(16), 1835-1847.
    [2] Johji Nomura et. Al. PLoS ONE, 8(9), e75527 (2013)

    分子式
    C16H16N2O3S
    分子量
    316.37
    CAS号
    144060-53-7
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    60 mg/mL
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01701622 Blood Pressure|Gout Drug: febuxostat University of Mississippi Medical Center 2010-01-01 2013-02-08
    NCT01763996 Coronary Artery Disease Drug: Febuxostat|Drug: Febuxostat placebo Takeda Phase 4 2013-05-01 2016-03-10
    NCT01350388 Chronic Kidney Disease|Diabetes Drug: Febuxostat|Drug: Placebo University of Utah|Takeda 2011-05-01 2016-08-09
    NCT01078389 Joint Damage Drug: Febuxostat|Drug: Placebo for Febuxostat Takeda Phase 2 2010-03-01 2014-09-03
    NCT01082640 Renal Impairment Drug: Febuxostat|Drug: Placebo Takeda Phase 2 2010-04-01 2013-09-23
    NCT00995618 Gout|Hyperuricemia Drug: Tranilast|Drug: Febuxostat|Drug: Combination - Tranilast and Febuxostat Nuon Therapeutics, Inc. Phase 2 2009-09-01 2011-01-05
    NCT01496469 Hypertension Drug: Febuxostat|Drug: Placebo Takeda Phase 2 2012-02-01 2015-07-31
    NCT01549977 Angina Drug: Febuxostat|Drug: Placebo Takeda Phase 2 2012-07-01 2013-10-30
    NCT01883167 Healthy Drug: RDEA3170 10 mg|Drug: Febuxostat 40 mg|Drug: placebo Ardea Biosciences, Inc. Phase 1 2013-06-01 2014-01-08
    NCT02374164 Gout Drug: Febuxostat XR Takeda Phase 1 2015-02-01 2016-03-25
    NCT01984749 Hyperuricemia Drug: Febuxostat Freed Study Group|Teijin Pharma 2013-11-01 2016-08-25
    NCT02279342 Coronary Artery Disease Drug: Febuxostat Yokohama City University Medical Center Phase 4 2014-10-01 2014-10-30
    NCT01724528 Tumor Lysis Syndrome Drug: Febuxostat|Drug: Allopurinol Menarini Group Phase 3 2012-10-01 2014-10-27
    NCT01472692 Prehypertension|Gout|Pulse Wave Velocity|Hypertension|24 Hour Blood Pressure Drug: Febuxostat University of California, San Diego Phase 4 2011-10-01 2014-03-31
    NCT02579096 Gout|Chronic Kidney Diseases Drug: Allopurinol|Drug: Febuxostat|Drug: Placebo, vehicle control (Febuxostat-shaped)|Drug: Placebo, vehicle control (Allopurinol-shaped) VA Office of Research and Development Phase 4 2017-03-06 2017-03-24
    NCT02504320 Healthy Volunteers Drug: Febuxostat XR 80 mg Capsule F1|Drug: Febuxostat XR 80 mg Capsule F2|Drug: Febuxostat XR 80 mg Capsule F3|Drug: Febuxostat XR 80 mg Capsule F4 Takeda Phase 1 2015-08-01 2016-11-25
    NCT00102440 Gout Drug: Febuxostat|Drug: Febuxostat|Drug: Allopurinol Takeda Phase 3 2002-07-01 2012-01-31
    NCT02752633 Adenine Phosphoribosyltransferase Deficiency Drug: Allopurinol|Drug: Febuxostat Landspitali University Hospital|Mayo Clinic|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Phase 4 2013-05-01 2016-04-22
    NCT02600780 Hyperuricemia Drug: Febuxostat|Drug: Allopurinol Getz Pharma Phase 4 2013-11-01 2015-11-06
    NCT02338323 Chronic Kidney Disease|Hyperuricemia|Abnormal Renal Function Drug: Febuxostat|Drug: Benzbromarone Shanghai 10th People's Hospital 2015-01-01 2016-05-05
    NCT01101035 Cardiovascular Disease Drug: Febuxostat|Drug: Allopurinol Takeda|Teijin America, Inc. Phase 3 2010-04-01 2016-08-17
    NCT00174915 Gout Drug: Febuxostat|Drug: Febuxostat|Drug: Febuxostat|Drug: Allopurinol|Drug: Placebo Takeda Phase 3 2003-02-01 2012-01-31
    NCT02944214 Chronic Kidney Disease|Hyperuricemia|Abnormal Renal Function Drug: Febuxostat|Drug: Benzbromarone Shanghai 10th People's Hospital 2016-10-01 2016-10-24
    NCT00175019 Gout Drug: Febuxostat|Drug: Febuxostat|Drug: Allopurinol Takeda Phase 3 2003-07-01 2010-07-22
    NCT01077284 Hyperuricosuria|Kidney Stones Drug: Febuxostat|Drug: Allopurinol|Drug: Placebo Takeda Phase 2 2010-02-01 2013-01-14

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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