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Nedaplatin

顺糖氨铂,萘达铂

Nedaplatin是顺铂衍生物和DNA损伤剂。

目录号
EY1665
EY1665
EY1665
EY1665
纯度
99.48%
99.48%
99.48%
99.48%
规格
5 mg
10 mg
25 mg
50 mg
原价
420
750
1385.00
2890
售价
420
750
1385.00
2890
库存
现货
现货
现货
现货
订购
订购
订购
订购
订购
订购
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  • 生物活性

    Nedaplatin is a derivative of cisplatin and DNA damage agent for tumor colony forming units with IC50 of 94 μM.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

    0.005 μg/mL, 0.01 μg/mL, 0.025 μg/mL, 0.05 μg/mL, 0.1 μg/mL, 0.25 μg/mL，0.5 μg/mL

  • 动物实验

    10 mg/kg或20 mg/kg静脉注射

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Alberts DS, et al. Cancer Chemother Pharmacol, 1997, 39(6), 493-497.

    分子式
    C2H8N2O3Pt    		 分子量
    303.18    		 CAS号
    95734-82-0    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    <1 mg/mL    		 Water
    15 mg/mL    		 Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01175460 Esophageal Cancer Drug: S-1, Nedaplatin Zhejiang Cancer Hospital Phase 1 2010-01-01 2012-03-04
    NCT02350517 Esophageal Squamous Cell Carcinoma Drug: Paclitaxel+Nedaplatin+Endostar Yuhong Li|Sun Yat-sen University Phase 2 2015-01-01 2016-11-08
    NCT01667211 Uterine Cervical Cancer Drug: albumin-bound paclitaxel plus nedaplatin Chinese Academy of Medical Sciences Phase 2 2011-11-01 2012-08-21
    NCT02861690 Esophageal Carcinoma Drug: Liposomal Paclitaxel|Drug: Nedaplatin Sun Yat-sen University Phase 2 2010-01-01 2016-08-05
    NCT02301208 Nasopharyngeal Carcinoma Drug: Nedaplatin|Drug: Cisplatin He Xia|Jiangsu Cancer Institute & Hospital Phase 3 2014-12-01 2014-12-05
    NCT01540136 Nasopharyngeal Carcinoma Drug: Nedaplatin|Drug: Cisplatin Sun Yat-sen University|Guangzhou Medical University|The First Affiliated Hospital of Guangdong Pharmaceutical University|Meizhou City Hospital Of Guangdong Provience Phase 3 2012-02-01 2016-10-27
    NCT02643407 Non-Small Cell Lung Cancer Drug: Docetaxel|Drug: Nedaplatin|Drug: Cisplatin Guangdong Association of Clinical Trials Phase 3 2015-10-01 2015-12-30
    NCT01265147 Nasopharyngeal Carcinoma Drug: Cisplatin|Drug: Nedaplatin Daping Hospital and the Research Institute of Surgery of the Third Military Medical University Phase 2 2011-01-01 2011-01-19
    NCT02088515 Squamous Cell Carcinoma Drug: Nedaplatin|Drug: Cisplatin|Drug: Docetaxel Jiangsu Simcere Pharmaceutical Co., Ltd. Phase 4 2013-12-01 2017-03-02
    NCT01479504 Nasopharyngeal Carcinoma Drug: nedaplatin and docetaxel|Drug: cisplatin and docetaxel|Drug: nedaplatin and docetaxel|Drug: cisplatin and docetaxel Guangxi Medical University|People's Hospital of Guangxi|303rd Hospital of the People's Liberation Army|Nanning Second People's Hospital|Guangxi Traditional Chinese Medical University|Guilin Medical College|Guangxi Naxishan Hospital|Liuzhou Worker's Hospital|Liuzhou People's Hospital|Liuzhou Hospital of Traditional Chinese Medicine|Liuzhou Cancer Hospital|Liuzhou Railway hospital|First People's Hospital of Yulin|The Red Cross hospital of YuLin|Guigang People's Hospital|The Red Cross hospital of Wuzhou Phase 3 2011-11-01 2011-11-24
    NCT00197444 Esophageal Cancer|Squamous Cell Carcinoma Drug: CDGP/5-FU combined with radiation|Radiation: Radiotherapy Hamamatsu University Phase 2 2003-01-01 2009-02-19
    NCT02964455 Esophageal Squamous Cell Carcinoma Drug: Docetaxel|Drug: Nedaplatin|Radiation: chest radiation Sun Yat-sen University Phase 1 2016-11-01 2016-11-13
    NCT02789189 Recurrent and Metastatic Nasopharyngeal Carcinoma Drug: nedaplatin and gemcitabine Sun Yat-sen University Phase 2 2016-06-01 2016-05-29
    NCT02590133 Nasopharyngeal Carcinoma Drug: Recombinant Human Endostatin Injection (Endostar)|Drug: Fluorouracil (5-Fu)|Drug: Nedaplatin Yun-fei Xia|Jiangsu Simcere Pharmaceutical Co., Ltd.|Sun Yat-sen University Phase 2 2015-07-01 2016-04-14
    NCT01735747 Central Nervous System Tumors Radiation: Radiotherapy|Drug: nedaplatin|Drug: vincristine|Drug: Temozolomide Rongjie Tao|National Natural Science Foundation of China|Shandong Cancer Hospital and Institute Phase 2 2008-06-01 2013-03-11
    NCT02537925 Nasopharyngeal Carcinoma Drug: Celecoxib|Drug: Nedaplatin|Radiation: Concurrent Radiotherapy Changjie Huang|Nanning Second People's Hospital Phase 3 2014-01-01 2015-08-28
    NCT02364804 Non-small Cell Lung Cancer Drug: Aprepitant Shiga University 2012-04-01 2015-09-21
    NCT01201044 Non-small Cell Lung Cancer Drug: Gemcitabine, Nedaplatin, iV|Radiation: 3DCRT|Radiation: 3DCRT|Drug: Gemcitabineedaplatin, BAI Third Military Medical University 2010-01-01 2010-09-13
    NCT02835404 Cervical Cancer|Complications Drug: Nedaplatin|Radiation: Pelvic External Radiotherapy|Radiation: 252-Cf Neutron Intracavitary Brachytherapy Daping Hospital and the Research Institute of Surgery of the Third Military Medical University Phase 2 2012-11-01 2016-07-13
    NCT01694576 Nasopharyngeal Carcinoma Drug: Adjuvant chemotherapy with paclitaxel and nedaplatin Jiangsu Cancer Institute & Hospital Phase 2 2012-09-01 2015-06-12

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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