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Tretinoin ATRA

维生素A酸,视黄酸,All-trans Retinoic Acid,ATRA,Tretinoin,Vitamin A acid

All-trans retinoic acid可作用于前列腺癌等众多癌症。

目录号
EY1656
EY1656
纯度
99.48%
99.48%
规格
100 mg
500 mg
原价
480
725
售价
480
725
库存
现货
现货
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  • 生物活性

    Tretinoin, which is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Manzano VM, et al. J Pharmacol Exp Ther, 1999, 289(1), 123-132.

    分子式
    C20H28O2    		 分子量
    300.44    		 CAS号
    302-79-4    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    60 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    6 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01448733 Acne Vulgaris Drug: Benzoyl peroxide 2.5%/clindamycin phosphate 1.2% in the morning with with tretinoin 0.05% gel in the evening Zeichner, Joshua, M.D. Phase 4 2011-07-01 2011-10-06
    NCT02261779 AML Drug: Tranylcypromine|Drug: Tretinoin Martin-Luther-Universitt Halle-Wittenberg Phase 1|Phase 2 2014-09-01 2015-07-06
    NCT01985477 Myeloma Drug: Lenalidomide|Drug: Dexamethasone|Drug: All-Trans Retinoic Acid (ATRA) M.D. Anderson Cancer Center|Celgene Corporation Phase 1 2013-12-01 2016-09-12
    NCT01048086 Neuroblastoma|Neuroendocrine Tumor Drug: Retinoic Acid|Drug: Placebo University of Iowa|Molecular Insight Pharmaceuticals, Inc. Phase 2 2009-06-01 2016-06-17
    NCT01820624 Adult Acute Megakaryoblastic Leukemia (M7)|Adult Acute Monoblastic Leukemia (M5a)|Adult Acute Monocytic Leukemia (M5b)|Adult Acute Myeloblastic Leukemia With Maturation (M2)|Adult Acute Myeloblastic Leukemia Without Maturation (M1)|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Adult Acute Myelomonocytic Leukemia (M4)|Adult Erythroleukemia (M6a)|Adult Pure Erythroid Leukemia (M6b)|Recurrent Adult Acute Myeloid Leukemia Drug: tretinoin|Drug: lithium carbonate|Other: laboratory biomarker analysis Paolo Caimi, MD|National Cancer Institute (NCI)|Case Comprehensive Cancer Center Phase 1 2013-04-01 2015-10-19
    NCT01406080 Photoaging|Photodamage Drug: Adapalene|Drug: Tretinoin Galderma Brasil Ltda. Phase 3 2013-01-01 2013-01-22
    NCT01349556 Medication Reaction Drug: Tretinoin Johns Hopkins University 2011-05-01 2014-04-21
    NCT01404949 Acute Promyelocytic Leukemia Drug: Tretinoin and Arsenic Trioxide Memorial Sloan Kettering Cancer Center|Northwestern University|New York Presbyterian Hospital|University of Southern California|Princess Margaret Hospital, Canada|National Heart, Lung, and Blood Institute (NHLBI) Phase 2 2011-07-01 2016-12-21
    NCT02249767 Acne Drug: Tretinoin Spear Pharmaceuticals Phase 3 2013-11-01 2014-12-04
    NCT01456468 Cholangitis, Sclerosing Drug: Oral all-trans retinoic acid (ATRA) Yale University|Mayo Clinic Phase 1 2011-10-01 2016-07-12
    NCT01283464 Photodamaged Skin|Wrinkles Drug: Retinol|Drug: Tretinoin Johns Hopkins University Phase 2 2010-11-01 2016-03-07
    NCT00240513 Acne Vulgaris Drug: Minocycline|Drug: Minocycline plus tretinoin Derm Research @ 888 Inc.|Stiefel, a GSK Company Phase 4 2004-08-01 2012-02-22
    NCT01027793 Stretch Marks|Striae|Treatment Drug: Tretinoin cream 0.005%|Device: Superficial Dermabrasion Brazilan Center for Studies in Dermatology Phase 4 2009-03-01 2012-02-28
    NCT00007631 Carcinoma, Basal Cell|Carcinoma, Squamous Cell|Skin Neoplasms Drug: Tretinoin 0.1% cream or placebo|Other: Placebo VA Office of Research and Development|Ortho Dermatologics Phase 3 1998-03-01 2009-01-29
    NCT02403778 Melanoma Drug: All-Trans Retinoic Acid|Drug: Ipilimumab University of Colorado, Denver Phase 2 2015-09-30 2017-02-06
    NCT00647556 Photoaging Drug: adapalene gel, 0.3%|Drug: tretinoin 0.05% emollient cream Galderma Laboratories, L.P. Phase 3 2008-04-01 2012-09-21
    NCT02842827 Acute Myeloid Leukemia|Myelodysplastic Syndrome Drug: IMG-7289|Drug: All-trans retinoic acid Imago BioSciences,Inc. Phase 1 2016-10-01 2016-10-10
    NCT01422785 Acne Vulgaris Drug: clindamycin phosphate 1.2%/tretinoin 0.025% gel alone|Drug: clindamycin phosphate 1.2%/tretinoin 0.025% gel plus benzoyl peroxide 6% foaming cloths Zeichner, Joshua, M.D. Phase 4 2011-07-01 2011-08-22
    NCT01125930 Rosacea Drug: vehicle gel|Drug: Atralin gel Lisa E. Maier|Valeant Pharmaceuticals International, Inc.|University of Michigan Phase 3 2010-05-01 2014-07-15
    NCT01575691 Myelodysplastic Syndrome|Acute Myelogenous Leukemia Drug: 5-Azacytidine (5-aza)|Drug: Valproic Acid|Drug: All-Trans Retinoic Acid (ATRA) M.D. Anderson Cancer Center|Celgene Corporation Phase 1 2005-07-01 2012-04-10
    NCT00717652 Melasma Drug: arbutin, tretinoin, triamcinolone|Drug: Triluma Azidus Brasil Phase 2|Phase 3 2008-07-01 2010-10-22
    NCT00621218 Rosacea Drug: tretinoin gel 0.05%|Drug: vehicle Coria Laboratories, Ltd. Phase 2 2008-02-01 2008-12-17
    NCT02273102 Acute Myelogenous Leukemia|Myelodysplastic Syndromes|Leukemia Drug: Tranylcypromine|Drug: Tretinoin University of Miami Phase 1 2015-03-02 2017-03-07
    NCT00835198 Acne Vulgaris Drug: Dapsone; Tretinoin|Drug: Tretinoin Allergan Phase 4 2008-12-01 2011-09-22

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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