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Zyloprim

别嘌呤醇,Allopurinol

Allopurinol 是黄嘌呤氧化酶(XO)抑制剂,IC50为7.82±0.12 μM。

目录号
EY1655
EY1655
EY1655
纯度
99.33%
99.33%
99.33%
规格
100 mg
500 mg
5 g
原价
200
300
398
售价
200
300
398
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Allopurinol is a purine analog inhibitor of the enzyme xanthine oxidase, used to treat gout or kidney stones, and to decrease levels of uric acid.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Kang SM, et al. Eur J Pharmacol,?006, 535(1-3), 212-219.

    分子式
    C5H4N4O
    分子量
    136.11
    CAS号
    315-30-0
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    27 mg/mL
    Water
    5 mg/mL
    Ethanol
    4 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02477488 Gout|Renal Insufficiency Drug: Allopurinol Maisonneuve-Rosemont Hospital Phase 4 2015-06-01 2016-09-12
    NCT02046694 Acute Lymphoblastic Leukemia (ALL) Drug: Allopurinol Sidney Kimmel Comprehensive Cancer Center Phase 1 2014-01-01 2017-03-06
    NCT02237339 Hypertension|Hypertrophy, Left Ventricular Drug: Allopurinol|Drug: Placebo University of Dundee|British Heart Foundation Phase 4 2014-09-01 2016-06-08
    NCT01092221 Mania Drug: Allopurinol|Drug: Placebo Sheba Medical Center Phase 3 2010-05-01 2012-05-06
    NCT00864825 Schizophrenia|Schizoaffective Disorder Drug: Allopurinol Sheba Medical Center Phase 4 2009-08-01 2012-05-06
    NCT01603134 Fasting State Drug: Allopurinol|Drug: Allopurinol IPCA Laboratories Ltd. Phase 1 2007-11-01 2012-05-21
    NCT01391325 Gout Drug: Allopurinol Ardea Biosciences, Inc. Phase 4 2011-07-01 2014-05-16
    NCT01775098 Gout Drug: allopurinol Universit de Sherbrooke 2013-12-10
    NCT00181155 Congestive Heart Failure Drug: Allopurinol|Drug: Placebo Johns Hopkins University|National Heart, Lung, and Blood Institute (NHLBI) Phase 2 2004-11-01 2016-01-06
    NCT01951404 End Stage Renal Disease|Left Ventricular Hypertrophy Drug: Allopurinol|Drug: Placebo (for allopurinol) University of Dundee|British Heart Foundation|NHS Tayside|NHS Greater Glasgow and Clyde|University of Glasgow Phase 4 2013-09-01 2016-11-03
    NCT01701622 Blood Pressure|Gout Drug: febuxostat University of Mississippi Medical Center 2010-01-01 2013-02-08
    NCT00849368 Inflammatory Bowel Disease Drug: Azathioprine / Allopurinol University of Zurich Phase 1 2009-01-01 2012-02-06
    NCT02956278 Chronic Gout|Hyperuricemia Drug: Allopurinol|Other: Placebo University of California, San Francisco|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|Open Medicine Institute Phase 4 2016-11-01 2016-11-02
    NCT02498652 Gout Drug: RDEA3170 2.5 mg|Drug: allopurinol 300 mg Ardea Biosciences, Inc. Phase 2 2015-07-01 2016-08-30
    NCT01987570 Patients With Grade II Ankle Sprain Drug: Allopurinol|Drug: Placebo Instituto de Investigacion Sanitaria La Fe Phase 3 2012-04-01 2016-09-07
    NCT01077284 Hyperuricosuria|Kidney Stones Drug: Febuxostat|Drug: Allopurinol|Drug: Placebo Takeda Phase 2 2010-02-01 2013-01-14
    NCT00732251 Bipolar Disorder|Mania|Mixed Mania Drug: Allopurinol Cedars-Sinai Medical Center|West Coast College of Biological Psychiatry Phase 4 2008-08-01 2012-03-26
    NCT01988402 Gout Drug: allopurinol|Drug: Placebo (sugar pill) Wilford Hall Medical Center|United States Air Force Phase 4 2007-12-01 2014-12-20
    NCT01609166 Hand-foot Syndrome Drug: Allopurinol|Drug: Placebo Fundaci贸 Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau Phase 2 2011-07-01 2014-05-22
    NCT01575379 Diabetic Nephropathies Drug: Allopurinol|Drug: Placebo Alessandro Doria|Steno Diabetes Center|University of Michigan|University of Minnesota - Clinical and Translational Science Institute|Joslin Diabetes Center Phase 4 2012-09-01 2016-02-22

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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