Allopurinol 是黄嘌呤氧化酶(XO)抑制剂,IC50为7.82±0.12 μM。
Allopurinol is a purine analog inhibitor of the enzyme xanthine oxidase, used to treat gout or kidney stones, and to decrease levels of uric acid.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Kang SM, et al. Eur J Pharmacol,?006, 535(1-3), 212-219.
分子式 C5H4N4O |
分子量 136.11 |
CAS号 315-30-0 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 27 mg/mL |
Water 5 mg/mL |
Ethanol 4 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT02477488 | Gout|Renal Insufficiency | Drug: Allopurinol | Maisonneuve-Rosemont Hospital | Phase 4 | 2015-06-01 | 2016-09-12 |
NCT02046694 | Acute Lymphoblastic Leukemia (ALL) | Drug: Allopurinol | Sidney Kimmel Comprehensive Cancer Center | Phase 1 | 2014-01-01 | 2017-03-06 |
NCT02237339 | Hypertension|Hypertrophy, Left Ventricular | Drug: Allopurinol|Drug: Placebo | University of Dundee|British Heart Foundation | Phase 4 | 2014-09-01 | 2016-06-08 |
NCT01092221 | Mania | Drug: Allopurinol|Drug: Placebo | Sheba Medical Center | Phase 3 | 2010-05-01 | 2012-05-06 |
NCT00864825 | Schizophrenia|Schizoaffective Disorder | Drug: Allopurinol | Sheba Medical Center | Phase 4 | 2009-08-01 | 2012-05-06 |
NCT01603134 | Fasting State | Drug: Allopurinol|Drug: Allopurinol | IPCA Laboratories Ltd. | Phase 1 | 2007-11-01 | 2012-05-21 |
NCT01391325 | Gout | Drug: Allopurinol | Ardea Biosciences, Inc. | Phase 4 | 2011-07-01 | 2014-05-16 |
NCT01775098 | Gout | Drug: allopurinol | Universit de Sherbrooke | 2013-12-10 | ||
NCT00181155 | Congestive Heart Failure | Drug: Allopurinol|Drug: Placebo | Johns Hopkins University|National Heart, Lung, and Blood Institute (NHLBI) | Phase 2 | 2004-11-01 | 2016-01-06 |
NCT01951404 | End Stage Renal Disease|Left Ventricular Hypertrophy | Drug: Allopurinol|Drug: Placebo (for allopurinol) | University of Dundee|British Heart Foundation|NHS Tayside|NHS Greater Glasgow and Clyde|University of Glasgow | Phase 4 | 2013-09-01 | 2016-11-03 |
NCT01701622 | Blood Pressure|Gout | Drug: febuxostat | University of Mississippi Medical Center | 2010-01-01 | 2013-02-08 | |
NCT00849368 | Inflammatory Bowel Disease | Drug: Azathioprine / Allopurinol | University of Zurich | Phase 1 | 2009-01-01 | 2012-02-06 |
NCT02956278 | Chronic Gout|Hyperuricemia | Drug: Allopurinol|Other: Placebo | University of California, San Francisco|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|Open Medicine Institute | Phase 4 | 2016-11-01 | 2016-11-02 |
NCT02498652 | Gout | Drug: RDEA3170 2.5 mg|Drug: allopurinol 300 mg | Ardea Biosciences, Inc. | Phase 2 | 2015-07-01 | 2016-08-30 |
NCT01987570 | Patients With Grade II Ankle Sprain | Drug: Allopurinol|Drug: Placebo | Instituto de Investigacion Sanitaria La Fe | Phase 3 | 2012-04-01 | 2016-09-07 |
NCT01077284 | Hyperuricosuria|Kidney Stones | Drug: Febuxostat|Drug: Allopurinol|Drug: Placebo | Takeda | Phase 2 | 2010-02-01 | 2013-01-14 |
NCT00732251 | Bipolar Disorder|Mania|Mixed Mania | Drug: Allopurinol | Cedars-Sinai Medical Center|West Coast College of Biological Psychiatry | Phase 4 | 2008-08-01 | 2012-03-26 |
NCT01988402 | Gout | Drug: allopurinol|Drug: Placebo (sugar pill) | Wilford Hall Medical Center|United States Air Force | Phase 4 | 2007-12-01 | 2014-12-20 |
NCT01609166 | Hand-foot Syndrome | Drug: Allopurinol|Drug: Placebo | Fundaci贸 Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | Phase 2 | 2011-07-01 | 2014-05-22 |
NCT01575379 | Diabetic Nephropathies | Drug: Allopurinol|Drug: Placebo | Alessandro Doria|Steno Diabetes Center|University of Michigan|University of Minnesota - Clinical and Translational Science Institute|Joslin Diabetes Center | Phase 4 | 2012-09-01 | 2016-02-22 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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