Halobetasol propionate是一种皮肤外用使用合成类固醇,具有抗炎,止痒和收缩血管的作用。
Halobetasol Propionate is an anti-inflammatory and a dermatologic agent commonly used to treat psoriasis.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Mohandas S, et al. Indian J Dermatol Venereol Leprol, 2009, 75(2), 186-187.
分子式 C25H31ClF2O5 |
分子量 484.96 |
CAS号 66852-54-8 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 100 mg/mL |
Water <1 mg/mL |
Ethanol 35 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT00715975 | Psoriasis | Drug: halobetasol|Drug: clobetasol | Azidus Brasil | Phase 2|Phase 3 | 2008-07-01 | 2010-08-31 |
NCT00865605 | Healthy | Drug: Halobetasol Propionate 0.05% Ointment, single exposure|Drug: Ultravate 0.05% ointment, single exposure | Actavis Inc. | Phase 1 | 2003-12-01 | 2010-08-13 |
NCT00865267 | Healthy | Drug: Ultravate 0.05% ointment, single exposure | Actavis Inc. | Phase 1 | 2003-12-01 | 2010-08-13 |
NCT00990561 | Stable Plaque Psoriasis | Drug: Ultravate ointment twice daily + LacHydrin lotion twice daily|Drug: Ultravate ointment once daily + LacHydrin lotion twice daily | University of California, San Francisco | Phase 4 | 2009-07-01 | 2012-12-04 |
NCT00802958 | Healthy | Drug: Halobetasol Propionate 0.05% Ointment-Reference Product|Drug: Halobetasol Propionate 0.05% Ointment-Test Product | Perrigo Company | 2003-07-01 | 2012-03-15 | |
NCT00803166 | Healthy | Drug: Halobetasol Propionate 0.05% Cream-Reference Product|Drug: Halobetasol Propionate 0.05% Cream-Test product 1|Drug: Halobetasol Propionate 0.05% Cream-Test Product 2 | Perrigo Company | 2004-01-01 | 2012-03-15 | |
NCT01111123 | Plaque Psoriasis | Drug: Lac-Hydrin lotion (ammonium lactate lotion 12%) ; UItravate ointment (halobetasol propionate ointment 0.05%)|Drug: Lac-Hydrin lotion (ammonium lactate lotion 12%); placebo ointment | Icahn School of Medicine at Mount Sinai | Phase 4 | 2009-01-01 | 2016-05-25 |
NCT01610596 | Psoriasis|Plaque Psoriasis | Drug: Halobetasol Propionate Lotion 0.05%|Drug: Placebo | Therapeutics, Inc. | Phase 2 | 2011-11-01 | 2016-04-11 |
NCT02785172 | Psoriasis | Drug: IDP-118 Vehicle Lotion|Drug: IDP-118 Vehicle Cream|Drug: IDP-118 Lotion|Drug: Ultravate Cream | Valeant Pharmaceuticals International, Inc. | Phase 2 | 2016-04-01 | 2016-08-15 |
NCT01166646 | Plaque Psoriasis | Drug: Halobetasol Proprionate Lotion 0.05%|Drug: Halobetasol Proprionate Cream 0.05% | Therapeutics, Inc. | Phase 2 | 2010-07-01 | 2016-04-11 |
NCT02785185 | Psoriasis | Drug: IDP-122 Vehicle Lotion|Drug: IDP-122 Vehicle Cream|Drug: IDP-122 Lotion|Drug: Ultravate Cream | Valeant Pharmaceuticals International, Inc. | Phase 2 | 2016-06-01 | 2016-08-15 |
NCT02462083 | Plaque Psoriasis | Drug: IDP-118 Lotion | Valeant Pharmaceuticals International, Inc.|Dow Pharmaceutical Sciences | Phase 3 | 2015-07-01 | 2016-08-15 |
NCT01404338 | Psoriasis | Drug: Halobetasol 0.05% ointment|Drug: Placebo Ointment | Patel, Rita Vikram, M.D. | Phase 1 | 2011-06-01 | 2011-07-27 |
NCT03065556 | Plaque Psoriasis | Drug: 188-0551 Solution|Drug: Vehicle Solution | Therapeutics, Inc. | Phase 2 | 2017-01-26 | 2017-02-22 |
NCT03058744 | Psoriasis | Drug: IDP-118 Lotion|Drug: HP Monad Lotion|Drug: Ultravate Cream|Drug: Tazorac Cream | Valeant Pharmaceuticals International, Inc. | Phase 1 | 2015-06-01 | 2017-02-16 |
NCT02515097 | Plaque Psoriasis | Drug: IDP-122 Lotion|Drug: IDP-122 Vehicle Lotion | Valeant Pharmaceuticals International, Inc. | Phase 3 | 2015-10-01 | 2016-05-24 |
NCT02514577 | Plaque Psoriasis | Drug: IDP-122 Lotion|Drug: IDP-122 Vehicle Lotion | Valeant Pharmaceuticals International, Inc. | Phase 3 | 2015-10-01 | 2016-05-24 |
NCT02045277 | Plaque Psoriasis | Drug: IDP-118 Lotion|Drug: IDP-118 Monad HP Lotion|Drug: IDP-118 Monad Taz Lotion|Drug: IDP-118 Vehicle Lotion | Valeant Pharmaceuticals International, Inc.|Dow Pharmaceutical Sciences | Phase 2 | 2014-02-01 | 2016-08-15 |
NCT00234728 | Psoriasis | Device: Occlusive dressing | Teikoku Pharma USA | 2005-09-01 | 2008-06-30 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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