Naringenin, a common dietary flavonoid abundantly present in fruits and vegetables, is believed to possess strong anti-proliferative properties and the ability to induce apoptosis in hepatoma cell lines.
Naringenin is a natural predominant flavanone derived from plant food, which is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Fuhr U, et al. Br J Clin Pharmacol, 1993, 35(4):431-436.
分子式 C15H12O5 |
分子量 272.25 |
CAS号 480-41-1 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO >50 mg/mL |
Water <1 mg/mL |
Ethanol 5 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01091077 | Hepatitis C Virus|HCV Infection|Chronic HCV|Hepatitis C | Dietary Supplement: Naringenin | Massachusetts General Hospital|Harvard University | Phase 1 | 2009-06-01 | 2015-09-21 |
NCT02627547 | Healthy | Behavioral: Normal training|Behavioral: De-training | University of Glasgow | 2013-09-01 | 2015-12-08 | |
NCT00539916 | Cardiovascular Disease Risk Factors | Behavioral: Regular orange juice consumption | University Hospital, Bordeaux | 2007-10-01 | 2008-08-15 | |
NCT02380144 | Healthy | Other: Fresh orange fruit and pasteurized fruit juice | University of Hohenheim | 2014-01-01 | 2016-10-30 | |
NCT01982734 | Pharmacokinetics of New Curcumin Formulations|Safety of New Curcumin Formulations | Dietary Supplement: curcumin | University of Hohenheim|German Federal Ministry of Education and Research | Early Phase 1 | 2012-11-01 | 2016-10-24 |
NCT03032861 | Intestinal Diseases | Other: Orange juice | So Paulo State University | 2016-09-01 | 2017-01-24 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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