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Tirofiban

替罗非班,MK-383,MK383,MK 383

Tirofiban是一种选择性上颚GPIIb/IIIa拮抗剂，可以抑制血小板聚集，IC50为9nM。

目录号
EY1648
EY1648
EY1648
EY1648
纯度
99.63%
99.63%
99.63%
99.63%
规格
5 mg
10 mg
50 mg
100 mg
原价
305
480
1360
2160
售价
305
480
1360
2160
库存
现货
现货
现货
现货
订购
订购
订购
订购
订购
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  • 生物活性

    Tirofiban (MK-383) is a selective palate GPIIb/IIIa antagonist which inhibits platelet aggregation with IC50 of 9 nM.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

    ~500 mg/kg 腹腔注射

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Hartman GD, et al. J Med Chem, 1992, 35(24), 4640-4642.

    分子式
    C22H36N2O5S    		 分子量
    440.6    		 CAS号
    144494-65-5    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    <1 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01766154 Renal Insufficiency Drug: Tirofiban Medicure Phase 1 2013-01-01 2014-03-25
    NCT01109134 Acute Myocardial Infarction Drug: tirofiban intracoronary bolus-only|Drug: tirofiban intravenous bolus plus infusion Kosuyolu Heart Hospital|The Society of Cardiac Health Protection Phase 3 2008-09-01 2010-04-21
    NCT02054000 No-Reflow Phenomenon Drug: Tirofiban|Other: Placebo TC Erciyes University Phase 4 2011-01-01 2014-02-01
    NCT00566891 Coronary Artery Disease Drug: tirofiban|Drug: Clopidogrel S. Anna Hospital Phase 4 2007-12-01 2011-02-01
    NCT02294994 Coronary Artery Disease Drug: tirofiban Second Hospital of Jilin University Phase 4 2014-11-01 2014-11-29
    NCT03048019 Non-ST Elevation Myocardial Infarction (NSTEMI) Drug: Tirofiban|Drug: Cangrelor Inova Health Care Services 2017-04-01 2017-03-03
    NCT01498003 Coronary Artery Disease Drug: tirofiban|Drug: normal saline solution Shanghai Jiao Tong University School of Medicine Phase 4 2011-11-01 2015-07-13
    NCT01181388 Myocardial Infarction Procedure: administration of tirofiban by thrombus aspiration catheter in infarct-related artery|Procedure: administration of tirofiban by guide catheter Beijing Anzhen Hospital 2010-04-01 2010-08-12
    NCT00398463 Angioplasty, Transluminal, Percutaneous Coronary Drug: Tirofiban|Drug: Placebo Universit degli Studi di Ferrara Phase 4 2006-05-01 2011-06-29
    NCT00407771 Coronary Artery Disease Drug: Tirofiban Jordan Hospital|Merck Sharp & Dohme Corp. Phase 4 2007-11-01 2007-10-30
    NCT00383136 Acute Myocardial Infarction Drug: tirofiban high-bolus dose regimen|Drug: Abciximab University of Bologna Phase 4 2003-06-01 2008-01-11
    NCT01522417 Myocardial Infarction|Acute Coronary Syndromes|Unstable Angina Drug: Short Tirofiban|Drug: Eptifibatide|Drug: Long Tirofiban Medicure|SCRI Development Innovations, LLC Phase 2 2012-04-01 2015-04-06
    NCT00538317 Acute Myocardial Infarction Drug: tirofiban|Drug: tirofiban Hospices Civils de Lyon Phase 4 2007-07-01 2008-11-21
    NCT02978040 Coronary Artery Disease|STEMI - ST Elevation Myocardial Infarction Drug: Cangrelor|Drug: Tirofiban|Drug: Prasugrel University Hospital Inselspital, Berne Phase 4 2017-02-01 2016-11-26
    NCT00306228 Myocardial Infarction Procedure: Postfibrinolysis percutaneous coronary intervention|Procedure: Postfibrinolysis percutaneous coronary intervention|Procedure: Postfibrinolysis percutaneous coronary intervention|Procedure: Postfibrinolysis percutaneous coronary intervention GRACIA Group|Spanish Ministry of Health.|Spanish Ministry of Science and Innovation Phase 4 2004-10-01 2009-09-25
    NCT01336348 ST Segment Elevation Myocardial Infarction Drug: Prasugrel|Drug: Tirofiban Universit degli Studi di Ferrara Phase 3 2010-04-01 2012-10-09
    NCT01660373 Non-ST Segment Elevation Acute Coronary Syndrome Drug: Tirofiban|Drug: Ticagrelor Pusan National University Yangsan Hospital|AstraZeneca Phase 3 2012-08-01 2012-12-16
    NCT01245725 Myocardial Infarction|Acute Coronary Syndromes|Unstable Angina|Percutaneous Coronary Intervention Drug: Tirofiban (Aggrastat)|Drug: Placebo Medicure|SCRI Development Innovations, LLC Phase 3 2015-04-07
    NCT00790387 Acute Coronary Syndrome Drug: Enoxaparin|Drug: Tirofiban|Drug: unfractionated heparin The Prince Charles Hospital|Sanofi|Merck Sharp & Dohme Corp. Phase 4 2004-06-01 2010-03-23
    NCT00229515 Myocardial Infarction Other: abciximab followed by implantation of bare metal stent|Other: abciximab and Sirolimus eluting stent|Other: tirofiban and bare metal stent|Other: tirofiban and sirolimus-eluting stent Marco Valgimigli|Universit degli Studi di Ferrara Phase 4 2004-11-01 2011-10-26
    NCT00611169 Acute Myocardial Infarction Drug: tirofiban Samsung Medical Center Phase 4 2006-01-01 2008-02-07
    NCT00300833 Acute Myocardial Infarction Drug: Tirofiban The Baruch Padeh Medical Center, Poriya Phase 4 2006-01-01 2011-08-10
    NCT02131220 Myocardial Infarction|Percutaneous Coronary Intervention|Thrombolytic Therapy Drug: Prourokinase|Drug: Tirofiban|Drug: normal saline Fudan University Phase 4 2015-11-01 2016-08-08
    NCT01696110 Acute Myocardial Infarction|Percutaneous Coronary Intervention Drug: Bivalirudin|Drug: heparin|Drug: heparin plus tirofiban Shenyang Northern Hospital Phase 4 2012-08-01 2014-09-30
    NCT00445263 CORONARY DISEASE Drug: TIROFIBAN|Procedure: CORONAROGRAPHY Hospital Avicenne Phase 4 2007-03-01 2015-02-09

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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